Organic Acids
Medchemexpress LLC WD6305 TFA | 99.8% | 1226.40 | 1 MG
WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. It has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. It also exhibits antitumor activity.
- Potent and selective PROTAC degrader.
- Inhibits m6A modification and proliferation of AML cells.
- Induces apoptosis.
- Has antitumor activity.
- For research use only.
Medchemexpress LLC ADWX 1 TFA | 98.4% | 4071.85 | 1 MG
ADWX 1 TFA is a novel peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. It inhibits Kv1.3 channel activity to specifically suppress both initial calcium signaling and NF-κB activation. This compound has demonstrated the ability to ameliorate experimental autoimmune encephalomyelitis (EAE) in rat models and is useful for studying T cell-mediated autoimmune diseases.
- Potent and selective Kv1.3 inhibitor with an IC50 of 1.89 pM
- Inhibits Kv1.3 channel activity
- Suppresses initial calcium signaling and NF-κB activation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) in rat models
- Useful for studying T cell-mediated autoimmune diseases
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 25 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It induces dose-dependent body weight loss in diet-induced obese mice. This product is for research use only.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces dose-dependent body weight loss in diet-induced obese mice
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes
- Improves glucose tolerance in diet-induced obese mice
- Reduces liver fat and inflammatory biomarkers in NASH model mice
Medchemexpress LLC Jbsnf-000028 tfa | C13H14F3N3O2 | 25 MG
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It reduces endogenous MNA levels in U2OS osteosarcoma cells and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. This compound is suitable for research into metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells with an EC50 of 2.5 μM.
- Shows no cytotoxicity against HepG2 cells at concentrations of 10-100 μM.
- Improves glucose and lipid handling in diet-induced obese mice.
- Enhances glucose tolerance in NNMT knockout mice with diet-induced obesity.
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 5 MG
L2P4 TFA is a peptide-based and EBNA1 targeting fluorescent probe. It inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. L2P4 TFA exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based probe
- EBNA1 targeting
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells
- Suitable for cancer targeted therapy and immunotherapy research
- Used in peptide-drug conjugates research
Medchemexpress LLC Ql9 tfa | 95.91% | 5 MG
QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR), intended for research use only.
- High-affinity alloantigen
- Specific for the 2C T cell receptor (TCR)
- Suitable for research applications
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386801-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.9% | 1323.35 | 1 MG
OncoACP3 TFA from MedChemExpress is a small-molecule ligand of prostatic acid phosphatase (ACP3). This product is applicable to research related to prostate cancer.
- Molecular formula: C62H82F3N12O15P
- Molecular weight: 1323.35
- Appearance: White to off-white solid
- Storage: Powder at -20°C for 3 years; in solvent at -80°C for 6 months, or -20°C for 1 month
- Purity (LCMS): 99.87%
Medchemexpress LLC F992 TFA | 98.19% | 1028.21 | 1 MG
F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analogue, intended for research use only. This solid, white to off-white compound has a molecular weight of 1028.21 (free base).
- Antidiuretic peptide and vasopressin analogue
- For research use only
- Solid appearance
- White to off-white color
Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 1 MG
CCZ01048 TFA is an α-MSH analogue that demonstrates high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It rapidly internalizes into B16F10 melanoma cells and exhibits high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma. The cationic Pip linker used in CCZ01048 improves tumor uptake and generates high tumor-to-normal tissue contrast in PET imaging within a preclinical melanoma model.
- Exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- Shows high in vivo stability
- Promising candidate for PET imaging of malignant melanoma
- Cationic Pip linker improves tumor uptake
- Generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC Wd6305 Tfa | 99.8% | 1226.40 | 5 MG
WD6305 TFA is a potent and selective PROTAC degrader targeting METTL3-METTL14. It inhibits m6A modification and proliferation of AML cells, and induces apoptosis. This compound also exhibits antitumor activity.
- Potent and selective PROTAC degrader
- Targets METTL3 and METTL14
- Inhibits m6A modification
- Inhibits proliferation of AML cells
- Induces apoptosis
- Exhibits antitumor activity
Medchemexpress LLC SAH-SOS1A TFA | 2896737-31-6 | 96.6% | 2301.55 | 1 MG
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. It binds to wild-type and mutant KRAS with nanomolar affinity, directly and independently blocking nucleotide association. This compound impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
- Peptide-based SOS1/KRAS protein interaction inhibitor
- Binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, Q61H) with nanomolar affinity (EC50=106-175 nM)
- Directly and independently blocks nucleotide association
- Impairs cancer cell viability
- Blocks ERK-MAPK phosphosignaling cascade downstream of KRAS
Medchemexpress LLC Wp9qy Tfa | 99.4% | 1340.40 | 5 MG
WP9QY TFA is a biologically active cyclic peptide designed as a TNF-α antagonist. It mimics the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, thereby preventing interactions of TNF with its receptor. This makes it a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.
- Acts as a TNF-α antagonist
- Designed to mimic TNF recognition loop on TNF receptor I
- Prevents TNF interactions with its receptor
- Useful for developing inhibitors for inflammatory bone destruction
- Helps prevent systemic bone loss in rheumatoid arthritis
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC c-Myc Peptide TFA | 2918768-02-0 | 99.97% | 1317.32 | 5 MG
c-Myc Peptide TFA is a synthetic peptide that corresponds to the C-terminal amino acids (410-419) of human c-myc protein. It is involved in the regulation of growth-related gene transcription.
- Synthetic peptide corresponding to C-terminal amino acids (410-419) of human c-myc protein.
- Regulates growth-related gene transcription.
- Plays a critical role in the growth of breast cancer cells in vitro.