Organic Acids
eMolecules 76045-93-7 | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC Mambalgin 1 TFA | 95.7% | 6554.54 | 100 UG
Mambalgin 1 TFA is a selective ASIC1a inhibitor with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer. It binds to closed/inactive channels and exhibits selectivity for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2 channels. It has been shown to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests. This product is for research use only.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
- For research use only
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.50 | 1 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Peptide inhibitor of Grb7
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM)
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines
Medchemexpress LLC Ω-Agatoxin IVA TFA | 99.10% | 5316.27 | 500 UG
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. It inhibits glutamate exocytosis and calcium influx elicited by high potassium (IC50, 30-225 nM) and also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.
- Potent, selective P/Q type Ca2+ (Cav2.1) channel blocker
- Inhibits glutamate exocytosis and calcium influx
- Blocks release of serotonin and norepinephrine
- No effect on L-type or N-type calcium channels
- Appearance: Solid
- Color: White to off-white
- For research use only
Medchemexpress LLC PD1-PDL1-IN 1 TFA | 2005454-12-4 | >99.5% | 385.38 g/mol | C14H23N7O6 | 1 ML
PD1-PDL1-IN 1 TFA is a small-molecule programmed cell death 1 (PD-1) inhibitor supplied as the trifluoroacetic acid (TFA) salt for research use. It is intended for use as an immune-modulating reagent in PD-1/PD-L1 pathway studies, screening, and preclinical laboratory assays.
- Potent PD-1 inhibition useful for pathway and mechanism studies.
- Supplied as a TFA salt to aid solubility and handling.
- Characterized with published CAS and molecular data for identification.
- Suitable for compound screening and preclinical research applications.
- Available in small research-scale formats for laboratory use.
Medchemexpress LLC 6H05 trifluoroacetate | 2061344-88-3 | 99.0% | 590.14 | C22H31ClF3N3O4S3 | 1MG
6H05 TFA is the trifluoroacetate salt of 6H05, a selective, allosteric inhibitor of the oncogenic mutant K-Ras(G12C) intended for biochemical and cellular research. Supplied as a solid or as a 10 mM DMSO solution, the compound is provided at high purity for assay development and mechanistic studies.
- Selective, allosteric inhibitor of K-Ras(G12C).
- High purity (99.02%).
- Molecular formula C22H31ClF3N3O4S3; molecular weight 590.14.
- Available in small-scale solid quantities and as a 10 mM DMSO solution.
- Suitable for biochemical and cellular assays; for research use only, not for human use.
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
Medchemexpress LLC VMIP-II (1-21) TFA | 5 MG
vMIP-II (1-21) (NT21MP) TFA is an inhibitor of CXCR4. It interacts broadly with CC and CXC chemokine receptors, inhibiting CXCR4 by competing with 125I-SDF-1R for binding sites (IC50=190 nM). This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C108H169N33O27S.xC2HF3O2
- Sequence: Leu-Gly-Ala-Ser-Trp-His-Arg-Pro-Asp-Lys-Cys-Cys-Leu-Gly-Tyr-Gln-Lys-Arg-Pro-Leu-Pro
- Target: CXCR
- Pathway: GPCR/G protein; immunology/inflammation
Medchemexpress LLC Dendrotoxin-I TFA | 99.1% | 7149.24 | 100 UG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin demonstrates potential for cancer research and is intended for research use only.
- Potent K+ channel blocker: Exhibits IC50s of 0.13-50 nM against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6.
- Neurotoxin with cancer research potential: Implicated in studies exploring its use in cancer research.
- In vivo activity: In an animal model using nude mice with MCF-7 cells, it showed a significant tumor growth inhibition effect when combined with hyperthermia.
Medchemexpress LLC Fn-439 TFA | 124168-73-6 | MFCD00237459 | 99.8% | 604.58 g·mol⁻¹ | C25H35F3N6O8 | 5 MG
FN-439 TFA is the trifluoroacetic acid salt of FN-439, a selective small-molecule inhibitor of collagenase-1 (matrix metalloproteinase). It inhibits collagenase-1 with an IC50 of 1 μM and is supplied as a research reagent for in vitro studies of cancer and inflammatory processes.
- Selective collagenase-1 inhibitor with reported IC50 of 1 μM.
- High purity (99.81%) suitable for biochemical assays.
- Trifluoroacetic acid salt form to aid solubility in aqueous systems.
- Supplied in research-scale quantities (e.g., five mg) for assay development.
- Intended for in vitro research applications; not for human use.
Medchemexpress LLC Achn-975 Tfa | 1410809-37-8 | 99.0% | 483.44 | 25 MG
ACHN-975 TFA is a selective LpxC inhibitor that demonstrates subnanomolar LpxC inhibitory activity. It is effective against a broad spectrum of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
- Selective LpxC inhibitor
- Exhibits subnanomolar LpxC inhibitory activity
- Effective against a wide range of gram-negative bacteria with low MIC values (≤1 μg/mL)
- Potent against *P. aeruginosa* isolates
- Demonstrates bactericidal activity against *P. aeruginosa* ATCC27853 strain in vivo.
Medchemexpress LLC Tfllr-nh2(tfa) | 1313730-19-6 | 99.6% | 761.83 | 50 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. It is for research use only and not sold to patients.
- Functions as a selective PAR1 agonist.
- Stimulates concentration-dependent increases in intracellular calcium.
- Modulates E-cadherin and vimentin expression in SW620 cells.
- Induces edema in rat paw models.
- Stimulates Evans blue extravasation in various mouse tissues.
- Exhibits both contraction and relaxation effects.
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.