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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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A hydroxy fatty acid and an active metabolite of 9-PAHSA; inhibits HDAC1 in HT-29 cell lysates at 5 µM; inhibits proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells at 100 µM
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Octadecane-1-thiol-d37 is the deuterium labeled Octadecane-1-thiol. It is for research use only and not sold to patients.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
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A hydroxy fatty acid; a low molecular weight gelator that self-assembles to form organogels; administration of paclitaxel in 12-hydroxy stearic acid-containing gel nanocarriers enhances tumor growth suppression in an H22 murine hepatocellular carcinoma model
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ATN-224 (bis(choline)tetrathiomolybdate) is an orally active Cu2+/Zn2+-dependent superoxide dismutase 1 (SOD1) inhibitor used in research to modulate copper-dependent enzymatic activity and angiogenesis. It inhibits SOD1 activity in endothelial and tumor cells and has been characterized in cellular and in vivo models.
Orally active Cu2+/Zn2+ SOD1 inhibitor with reported IC50 ~17.5 nM in endothelial cells.
High affinity copper binder, showing selectivity against Ca, Fe, Mg, Zn, and Mn up to 1 mM.
Inhibits proliferation of HUVEC cells (IC50 ~1.4 μM) and purified SOD1 (IC50 ~0.33 μM after 24 h).
Time-dependent SOD1 inhibition, reaching maximal effect at ~16 hours.
Demonstrated inhibition of angiogenesis in Matrigel plug models in mice.
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Stearic acid-PEG-Mal (average MW 5000) is a heterobifunctional pegylated lipid consisting of a stearic acid moiety linked to a polyethylene glycol chain terminated with a maleimide group. It is used as a thiol-reactive amphiphilic reagent for conjugation to cysteine-containing biomolecules, surface modification, and nanoparticle functionalization in biochemical assays. For research use only.
Heterobifunctional reagent with maleimide for thiol conjugation.
Average molecular weight 5000 providing a PEG spacer.
Amphiphilic stearic acid tail enables membrane or particle incorporation.
Suitable for surface modification and nanoparticle functionalization.
Storage: sealed at 4°C; in solvent store at -80°C up to 6 months or -20°C up to 1 month.
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Dimethyl pentadecanedioate is the dimethyl ester of pentadecanedioic acid and is supplied for laboratory research use as a chemical reagent and analytical standard. It is suitable for use in organic synthesis, method development, and other analytical applications requiring a high-purity long-chain diester.
Purity approximately 99%.
Molecular weight 300.43 g/mol.
Molecular formula C17H32O4.
CAS number 36575-82-3.
Pack size 50 G.
Suitable for organic synthesis and analytical method development.
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TPI-287 is a blood-brain barrier-permeable microtubule stabilizer that can significantly reduce metastatic colonization of breast cancer in the brain. This product is for research use only.
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N-Heptadecane is a straight-chain saturated hydrocarbon used as a technical reagent and analytical standard. It serves as an internal standard, tracer, and reference compound in chromatographic and mass spectrometric analyses, and is supplied with supporting documentation for laboratory use.
High purity analytical reagent suitable for standards and calibration.
Useful as an internal standard or tracer in GC/MS and chromatographic methods.
Chemical formula C17H36; molecular weight 240.47 g/mol.
Available in laboratory pack sizes including 50 G.
Storage recommendations: pure form at -20°C (long-term) or 4°C (short-term); in solvent at -80°C for extended stability.
Documentation available: data sheet, SDS, COA.
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Octadecane is an alkane used to store thermal energy at ambient temperature as a phase change material. It is for research use only and not sold to patients.
Purity of 98.0%
Molecular weight: 254.49
Formula: C18H38
Appearance: solid below 28°C, liquid above 28°C
Color: colorless to off-white
Melting/freezing point: 28°C
Target: biochemical assay reagents
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor used as a research reagent to inhibit dynamin I and II and to block clathrin-mediated endocytosis in cells.
Potent inhibitor of dynamin I (IC50 = 0.56 μM).
Active in cells to inhibit clathrin-mediated endocytosis (IC50 ≈ 1.9 μM).
Shows selectivity for dynamin I over dynamin II (≈4.4-fold).
High purity suitable for biochemical and cellular assays.
Available in small research quantities as an oil for convenient handling.
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