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Organic compounds with acidic properties, and will commonly have carboxylic acids or similar functional groups in their structure. Derived compounds are also included.
Methyl methanesulfonate (MMS) a DNA alkylating agent modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks respectively
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PF-06424439 methanesulfonate (CAS No 1469284-79-4) is a compound under investigation in biomedical research primarily within the category of oncology It originates from medicinal chemistry efforts to develop novel therapeutics targeting specific cellular pathways involved in cancer progression Its mechanism of action involves inhibition of key kinases disrupting signaling pathways crucial for tumor cell proliferation and survival This compound demonstrates in vitro activity typically in the nanomolar to low micromolar range indicating potent efficacy against targeted cancer cells Common applications include studies in cancerous cell models and preclinical animal studies to evaluate therapeutic potential Additionally it plays a role in drug screening processes to identify promising candidates for further development Experimental concentrations typically depend on the specific research design employed in these studies
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Also available in 2 mg 5 mg 10 mg 25 mg 50 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM). purity: 99%
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