Organoheterocyclic compounds
2-Amino-5-phenylpyridine 98.0+%, TCI America™
CAS: 33421-40-8 Molecular Formula: C11H10N2 Molecular Weight (g/mol): 170.22 MDL Number: MFCD01692452 InChI Key: OAPVIBHQRYFYSE-UHFFFAOYSA-N Synonym: 2-amino-5-phenylpyridine,5-phenyl-2-pyridinamine,2-pyridinamine, 5-phenyl,phe-p-1,5-phenyl-pyridin-2-ylamine,5-phenylpyridin-2-ylamine,2-amino-5-phenyl pyridine,pyridine, 2-amino-5-phenyl,acmc-1adxr,5-phenyl-2-pyridylamine PubChem CID: 105097 IUPAC Name: 5-phenylpyridin-2-amine SMILES: NC1=CC=C(C=N1)C1=CC=CC=C1
2,3-Dichloro-5-nitropyridine 98.0+%, TCI America™
CAS: 22353-40-8 Molecular Formula: C5H2Cl2N2O2 Molecular Weight (g/mol): 192.983 MDL Number: MFCD03840432 InChI Key: XLPDVAVQKGDHNO-UHFFFAOYSA-N PubChem CID: 2763106 IUPAC Name: 2,3-dichloro-5-nitropyridine SMILES: C1=C(C=NC(=C1Cl)Cl)[N+](=O)[O-]
Methyl Indazole-6-carboxylate 97.0+%, TCI America™
CAS: 170487-40-8 Molecular Formula: C9H8N2O2 Molecular Weight (g/mol): 176.175 MDL Number: MFCD07371612 InChI Key: TUSICEWIXLMXEY-UHFFFAOYSA-N Synonym: 1h-indazole-6-carboxylic acid methyl ester,methyl indazole-6-carboxylate,indazole-6-carboxylic acid methyl ester,6-1h indazole carboxylic acid methyl ester,1h-indazole-6-carboxylic acid, methyl ester,pubchem18064,methyl indazole-6carboxylate,ksc494o4p,methyl-1h-indazole-6-carboxylate,2h-indazole-6-carboxylic acid methyl ester PubChem CID: 286535 IUPAC Name: methyl 1H-indazole-6-carboxylate SMILES: COC(=O)C1=CC2=C(C=C1)C=NN2
2-Chloro-5-methyl-3-nitropyridine 98.0+%, TCI America™
CAS: 23056-40-8 Molecular Formula: C6H5ClN2O2 Molecular Weight (g/mol): 172.568 InChI Key: LUAJUWOJEFFNFE-UHFFFAOYSA-N Synonym: 2-chloro-3-nitro-5-picoline,2-chloro-3-nitro-5-methylpyridine,2-chloro-5-methyl-3-nitro-pyridine,2-chloro-5-methyl-3-nitro pyridine,pyridine, 2-chloro-5-methyl-3-nitro,pubchem6171,acmc-1ciox,ksc496c3p,6-chloro-5-nitro-3-picoline PubChem CID: 818300 IUPAC Name: 2-chloro-5-methyl-3-nitropyridine SMILES: CC1=CC(=C(N=C1)Cl)[N+](=O)[O-]
N-(tert-Butoxycarbonyl)-L-prolinol 98.0+%, TCI America™
CAS: 69610-40-8 Molecular Formula: C10H19NO3 Molecular Weight (g/mol): 201.266 MDL Number: MFCD00066232 InChI Key: BFFLLBPMZCIGRM-QMMMGPOBSA-N Synonym: n-boc-l-prolinol,boc-l-prolinol,s-1-boc-2-pyrrolidinemethanol,s-tert-butyl 2-hydroxymethyl pyrrolidine-1-carboxylate,tert-butyl 2s-2-hydroxymethyl pyrrolidine-1-carboxylate,1-boc-l-prolinol,n-tert-butoxycarbonyl-l-prolinol,boc-prolinol,s---1-boc-2-pyrrolidinemethanol,boc-pro-ol PubChem CID: 643448 IUPAC Name: tert-butyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate SMILES: CC(C)(C)OC(=O)N1CCCC1CO
Apexbio Technology LLC Ercalcidiol 21343-40-8 5mg
Ercalcidiol (CAS 21343-40-8) is a metabolite targeting vitamin D receptor (VDR)-like receptors It is involved in modulating mineral homeostasis by participating in the physiological regulation of calcium and phosphorus balance Ercalcidiol exerts its biological activity primarily through binding to VDR-related receptors In isolated perfused rat kidney experimental models Ercalcidiol is metabolized into several di- and tri-hydroxylated vitamin D2 derivatives supporting studies of vitamin D2 metabolism pathways Based on these pharmacological properties Ercalcidiol holds research potential for assessing vitamin D nutritional status and investigating vitamin D2 metabolism
Apexbio Technology LLC SPQ 83907-40-8 50mg
SPQ (CAS 83907-40-8) is a fluorescent probe used to monitor membrane-associated ion transport events It is designed to facilitate the detection of dynamic activities of membrane-bound ion channels and transport proteins by measuring changes in fluorescence intensity governed by ion-sensitive quenching mechanisms SPQ exerts its functional utility through ionic concentration-dependent fluorescence quenching enabling researchers to directly assess ion flux across cellular or subcellular membranes Based on these properties SPQ holds research potential in studies of membrane physiology transporter protein functionality and ion regulatory pathways in cell biology and pharmacological research
Apexbio Technology LLC SPQ 83907-40-8 100mg
SPQ (CAS 83907-40-8) is a fluorescent probe used to monitor membrane-associated ion transport events It is designed to facilitate the detection of dynamic activities of membrane-bound ion channels and transport proteins by measuring changes in fluorescence intensity governed by ion-sensitive quenching mechanisms SPQ exerts its functional utility through ionic concentration-dependent fluorescence quenching enabling researchers to directly assess ion flux across cellular or subcellular membranes Based on these properties SPQ holds research potential in studies of membrane physiology transporter protein functionality and ion regulatory pathways in cell biology and pharmacological research
Apexbio Technology LLC SR 11237 146670-40-8 5mg
SR 11237 (146670-40-8) is a small-molecule agonist targeting the retinoid X receptor (RXR) It is designed to selectively activate RXR thereby modulating RXR-mediated transcriptional regulation SR 11237 exerts its biological activity primarily through specific binding to RXR facilitating RXR-RXR homodimer formation and activating genes via RXR response elements Based on these pharmacological properties SR 11237 holds research potential in the investigation of RXR-dependent transcription nuclear receptor signaling pathways and therapeutic strategies related to RXR-associated diseases
Apexbio Technology LLC ABT-199 1257044-40-8 10mg
ABT-199 (CAS 1257044-40-8) is a selective small-molecule inhibitor targeting BCL-2 developed through structure-guided drug design By specifically interfering with the mitochondrial apoptotic pathway regulated by BCL-2 ABT-199 induces apoptosis predominately in cells dependent on BCL-2 signaling rather than BCL-XL In preclinical assessments ABT-199 exhibited antitumor activity against hematologic malignancies including BCL-2-dependent non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML) cell lines and xenograft models while demonstrating minimal platelet toxicity
Apexbio Technology LLC ABT-199 1257044-40-8 100mg
ABT-199 (CAS 1257044-40-8) is a selective small-molecule inhibitor targeting BCL-2 developed through structure-guided drug design By specifically interfering with the mitochondrial apoptotic pathway regulated by BCL-2 ABT-199 induces apoptosis predominately in cells dependent on BCL-2 signaling rather than BCL-XL In preclinical assessments ABT-199 exhibited antitumor activity against hematologic malignancies including BCL-2-dependent non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML) cell lines and xenograft models while demonstrating minimal platelet toxicity
Apexbio Technology LLC ARN-509 956104-40-8 5mg
ARN-509 is a synthetic biaryl thiohydantoin derivative acting as a competitive inhibitor of the androgen receptor (AR) It binds AR with an IC50 of approximately 16 nmol/L blocking receptor-mediated signaling pathways implicated in prostate cell proliferation Androgen receptor is a nuclear hormone receptor crucial for male sexual differentiation and prostate cancer cell growth Overexpression or hyperactivation of AR frequently occurs in castration-resistant prostate cancer Experimental data indicate that ARN-509 treatment reduces AR-driven transcription and inhibits cell proliferation in prostate cancer cell lines such as LNCaP and VCaP In murine xenograft models oral dosing of ARN-509 diminishes androgen-dependent reporter gene activity reduces tumor cell proliferation and induces apoptosis ARN-509 is utilized in biomedical research to investigate AR signaling and prostate cancer therapeutics
Apexbio Technology LLC ARN-509 956104-40-8 50mg
ARN-509 is a synthetic biaryl thiohydantoin derivative acting as a competitive inhibitor of the androgen receptor (AR) It binds AR with an IC50 of approximately 16 nmol/L blocking receptor-mediated signaling pathways implicated in prostate cell proliferation Androgen receptor is a nuclear hormone receptor crucial for male sexual differentiation and prostate cancer cell growth Overexpression or hyperactivation of AR frequently occurs in castration-resistant prostate cancer Experimental data indicate that ARN-509 treatment reduces AR-driven transcription and inhibits cell proliferation in prostate cancer cell lines such as LNCaP and VCaP In murine xenograft models oral dosing of ARN-509 diminishes androgen-dependent reporter gene activity reduces tumor cell proliferation and induces apoptosis ARN-509 is utilized in biomedical research to investigate AR signaling and prostate cancer therapeutics
Apexbio Technology LLC SR 11237 146670-40-8 25mg
SR 11237 (146670-40-8) is a small-molecule agonist targeting the retinoid X receptor (RXR) It is designed to selectively activate RXR thereby modulating RXR-mediated transcriptional regulation SR 11237 exerts its biological activity primarily through specific binding to RXR facilitating RXR-RXR homodimer formation and activating genes via RXR response elements Based on these pharmacological properties SR 11237 holds research potential in the investigation of RXR-dependent transcription nuclear receptor signaling pathways and therapeutic strategies related to RXR-associated diseases
Apexbio Technology LLC SR 11237 146670-40-8 10mg
SR 11237 (146670-40-8) is a small-molecule agonist targeting the retinoid X receptor (RXR) It is designed to selectively activate RXR thereby modulating RXR-mediated transcriptional regulation SR 11237 exerts its biological activity primarily through specific binding to RXR facilitating RXR-RXR homodimer formation and activating genes via RXR response elements Based on these pharmacological properties SR 11237 holds research potential in the investigation of RXR-dependent transcription nuclear receptor signaling pathways and therapeutic strategies related to RXR-associated diseases