Organoheterocyclic compounds
Medchemexpress LLC HY-13307 5mg Medchemexpress, JK184 CAS:315703-52-7 Purity:>98%
Medchemexpress, HY-13307 5mg JK184 CAS:315703-52-7 JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Methyl Red 92.0+%, TCI America™
CAS: 493-52-7 Molecular Formula: C15H15N3O2 Molecular Weight (g/mol): 269.304 MDL Number: MFCD00002425 InChI Key: CEQFOVLGLXCDCX-UHFFFAOYSA-N Synonym: methyl red,o-methyl red,c.i. acid red 2,acid red 2,cerven methylova,cerven kysela 2,4-dimethylamino-2'-carboxylazobenzene,2-carboxy-4'-dimethylamino azobenzene,2-4-dimethylaminophenylazo benzoic acid,ci acid red 2 PubChem CID: 10303 IUPAC Name: 2-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid SMILES: CN(C)C1=CC=C(C=C1)N=NC2=CC=CC=C2C(=O)O
7-Ethyl-10-hydroxycamptothecin 98.0+%, TCI America™
CAS: 86639-52-3 Molecular Formula: C22H20N2O5 Molecular Weight (g/mol): 392.411 MDL Number: MFCD06762720 InChI Key: FJHBVJOVLFPMQE-QFIPXVFZSA-N Synonym: 7-ethyl-10-hydroxycamptothecin,sn 38 lactone,7-ethyl-10-hydroxy-camptothecin,10-hydroxy-7-ethylcamptothecin,7-ethyl-10-hydroxycamptothecine,le-sn38,7-ethyl-10-hydroxy-20 s-camptothecin,captothecin, 7-ethyl-10-hydroxy,s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione,7-ethyl-10-hydroxy camptothecin PubChem CID: 104842 ChEBI: CHEBI:8988 SMILES: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
2,6-Dimethyl-3-nitropyridine 98.0+%, TCI America™
CAS: 15513-52-7 Molecular Formula: C7H8N2O2 Molecular Weight (g/mol): 152.153 MDL Number: MFCD00023503 InChI Key: AETHUDGJSSKZKT-UHFFFAOYSA-N PubChem CID: 84958 IUPAC Name: 2,6-dimethyl-3-nitropyridine SMILES: CC1=NC(=C(C=C1)[N+](=O)[O-])C
Methyl Red 98.0+%, TCI America™
CAS: 493-52-7 Molecular Formula: C15H15N3O2 Molecular Weight (g/mol): 269.304 MDL Number: MFCD00002425 InChI Key: CEQFOVLGLXCDCX-UHFFFAOYSA-N Synonym: methyl red,o-methyl red,c.i. acid red 2,acid red 2,cerven methylova,cerven kysela 2,4-dimethylamino-2'-carboxylazobenzene,2-carboxy-4'-dimethylamino azobenzene,2-4-dimethylaminophenylazo benzoic acid,ci acid red 2 PubChem CID: 10303 IUPAC Name: 2-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid SMILES: CN(C)C1=CC=C(C=C1)N=NC2=CC=CC=C2C(=O)O
1-(3-Chloropropyl)theobromine 97.0+%, TCI America™
CAS: 74409-52-2 Molecular Formula: C10H13ClN4O2 Molecular Weight (g/mol): 256.69 MDL Number: MFCD00059926 InChI Key: JMOWKXFNJSTXBW-UHFFFAOYSA-N Synonym: 1-(3-Chloropropyl)-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione, 1-(3-Chloropropyl)-3,7-dimethylxanthine PubChem CID: 13020469 IUPAC Name: 1-(3-chloropropyl)-3,7-dimethylpurine-2,6-dione SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)CCCCl
Lomefloxacin Hydrochloride 98.0+%, TCI America™
CAS: 98079-52-8 Molecular Formula: C17H20ClF2N3O3 Molecular Weight (g/mol): 387.812 MDL Number: MFCD00214312 InChI Key: KXEBLAPZMOQCKO-UHFFFAOYSA-N Synonym: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrochloride PubChem CID: 68624 ChEBI: CHEBI:6518 IUPAC Name: 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Apexbio Technology LLC CITCO 338404-52-7 5mg
CITCO (CAS 338404-52-7) is an imidazothiazole derivative that selectively activates the human constitutive androstane receptor (CAR) exhibiting an EC50 of 49 nM and over 50-fold selectivity for CAR compared to the pregnane X receptor (PXR) with negligible activity on other nuclear receptors Activation of CAR by CITCO facilitates its nuclear translocation and subsequent binding to response elements regulating gene expression processes involved in hepatic detoxification pathways Additionally CITCO-mediated CAR activation has been shown to suppress the proliferation and expansion of brain tumor stem cells supporting its utility in studies of xenobiotic metabolism and cancer biology
Apexbio Technology LLC CITCO 338404-52-7 25mg
CITCO (CAS 338404-52-7) is an imidazothiazole derivative that selectively activates the human constitutive androstane receptor (CAR) exhibiting an EC50 of 49 nM and over 50-fold selectivity for CAR compared to the pregnane X receptor (PXR) with negligible activity on other nuclear receptors Activation of CAR by CITCO facilitates its nuclear translocation and subsequent binding to response elements regulating gene expression processes involved in hepatic detoxification pathways Additionally CITCO-mediated CAR activation has been shown to suppress the proliferation and expansion of brain tumor stem cells supporting its utility in studies of xenobiotic metabolism and cancer biology
Apexbio Technology LLC Azelnidipine 123524-52-7 10mg
Azelnidipine (CAS 123524-52-7) is a dihydropyridine-based small molecule that functions as an L-type calcium channel blocker By inhibiting calcium influx through these channels azelnidipine effectively modulates vascular smooth muscle tone resulting in vasodilation and reduced blood pressure In preclinical studies acute administration of azelnidipine has been shown to prevent abrupt declines in cardiac function following acute stress events This compound is utilized in biomedical research to investigate the cellular and systemic mechanisms underlying calcium channel modulation and the physiological response to antihypertensive therapies
Apexbio Technology LLC CITCO 338404-52-7 10mg
CITCO (CAS 338404-52-7) is an imidazothiazole derivative that selectively activates the human constitutive androstane receptor (CAR) exhibiting an EC50 of 49 nM and over 50-fold selectivity for CAR compared to the pregnane X receptor (PXR) with negligible activity on other nuclear receptors Activation of CAR by CITCO facilitates its nuclear translocation and subsequent binding to response elements regulating gene expression processes involved in hepatic detoxification pathways Additionally CITCO-mediated CAR activation has been shown to suppress the proliferation and expansion of brain tumor stem cells supporting its utility in studies of xenobiotic metabolism and cancer biology
Medchemexpress LLC Pellitorine | 18836-52-7 | 1 MG
Pellitorine is a bioactive natural amide compound that competitively antagonizes TRPV1 activation, thereby reducing pain signal transmission. It improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways, and exerts anti-inflammatory and anti-sepsis effects. Additionally, Pellitorine exhibits antithrombotic activity, inhibits lipid peroxidation, resists ferroptosis, and shows anti-cancer properties. It also acts as an insecticide against Aedes aegypti mosquito larvae.
- Reduces pain by antagonizing TRPV1 activation.
- Improves cognitive function via BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways.
- Exerts anti-inflammatory and anti-sepsis effects.
- Provides antithrombotic effects.
- Inhibits lipid peroxidation and resists ferroptosis.
- Kills Aedes aegypti mosquito larvae.
- Exhibits anti-cancer activity (leukemia and breast cancer).
- Inhibits growth of certain bacteria.
Medchemexpress LLC Vorasidenib 25mg | 1644545-52-7 | 25MG
Vorasidenib (AG-881) is an orally available brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG) and the IC50 ranges of 0 04 22 nM against IDH1 R132C IDH1 R132G IDH1 R132H and IDH1 R132S and 7 14 nM against IDH2 R140Q and 130 nM against IDH2 R172K Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation[1 [2