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Indirubin-3 -oxime (CAS 160807-49-8) is a derivative of indirubin investigated primarily as an inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 22 nM This compound also inhibits CDK5/p25 and CDK1/cyclin B with IC50 values of around 100 nM and 180 nM respectively while demonstrating weaker inhibitory activity against 5-lipoxygenase (IC50 7 8 10 M) Due to its modulation of multiple kinases involved in cell signaling Indirubin-3 -oxime is widely utilized in research on cellular signaling pathways and the molecular mechanisms underlying disease
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Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. It is a mixture of oximes derived from milbemycin A4 and A3. This compound binds to glutamate-gated chloride channels and demonstrates inhibitory potency against intestinal nematodes and lung/heart worms.
Orally active macrolide
Broad-spectrum antiparasitic activity
Binds to glutamate-gated chloride channels
Demonstrates inhibitory potency against intestinal nematodes and lung/heart worms
Prevents *Angiostrongylus vasorum* infection in dogs when combined with Afoxolaner
Reduces geometric mean worm count
Reduces geometric mean faecal larval counts
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Propan-2-one oxime is a type of biological material or organic compound extensively utilized in life science research. It is intended for research use only and is not sold to patients.
Utilized in life science research.
Used as a laboratory chemical in the manufacture of substances.
Appears as a white to off-white solid.
Consistent 1H NMR spectrum.
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Acetophenone (Methyl phenyl ketone Phenylethanone) is an organic compound used as fragrances and a raw material for the synthesis of some pharmaceuticals
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. It is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. This compound binds to glutamate-gated chloride channels and demonstrates inhibitory potency against intestinal nematodes and lung/heart worms.
Orally active macrolide
Offers broad-spectrum antiparasitic activity
Binds to glutamate-gated chloride channels
Inhibits intestinal nematodes
Inhibits lung and heart worms
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Biacetyl monoxime (Diacetyl monoxime) a myosin ATPase inhibitor is a skeletal and cardiac muscle contraction inhibitor Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II Biacetyl monoxime induces sarcoplasmic reticulum Ca2 release[1][2][3]
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