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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. It attenuates Apomorphine-induced climbing and Phencyclidine-induced head twitches. It is for research use only and not sold to patients.
Selective functional antagonist of sigma receptors.
Attenuates Apomorphine-induced climbing.
Attenuates Phencyclidine-induced head twitches.
Prevents Cutamesine from reducing cell death induced by light exposure in murine photoreceptor-derived 661w cells.
Attenuates Cutamesine from reducing mitochondrial damage and elevated caspase 3/7 activity.
Decreases APO-induced climbing behavior at 10 mg/kg in mice.
Counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline.
Reduces the increasing expression of pNR1 and reverses Sig-1 R agonists potentiated NMDA-induced pain behavior and pNR1 immunoreactivity.
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Navlimetostat hydrochloride is a research-grade small-molecule inhibitor selective for the PRMT5-MTA complex. It demonstrates potent biochemical and cellular activity and is used in preclinical studies to probe PRMT5 biology and evaluate antineoplastic effects, with reported selectivity in MTAP-deleted models.
Potent inhibitor of the PRMT5-MTA complex (IC50 3.6 nM).
Inhibits PRMT5 enzymatic activity (IC50 20.5 nM).
Shows cellular selectivity in MTAP-deleted models (cell viability 12 nM vs 890 nM in parental cells).
High purity (99.2%).
Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
Suitable for preclinical research; store sealed away from moisture.
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