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Elacridar hydrochloride (GF120918A) is an orally active dual-inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). This compound is used for research to examine the influence of efflux transporters on agent distribution to the brain and for cancer research.
Orally active P-glycoprotein (P-gp) inhibitor
Orally active breast cancer resistance protein (BCRP) inhibitor
Used to examine the influence of efflux transporters on agent distribution to the brain
Applicable for cancer research
Inhibits cell viability of 786-O cells in vitro
Affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines
Increases ⁹⁹mTc-MIBI intracellular accumulation in MCF-7 and 786-O cell lines
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