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Nabumetone (CAS 42924-53-8) is a non-steroidal anti-inflammatory compound that undergoes hepatic metabolism to yield its active form 6-methoxy-2-naphthylacetic acid (6-MNA) The active metabolite selectively inhibits cyclooxygenase (COX) particularly COX-2 resulting in reduced synthesis of prostaglandins involved in inflammation and pain signaling Nabumetone is commonly utilized in research to study prostaglandin-mediated inflammatory pathways COX enzyme function and the pharmacological modulation of inflammatory responses in preclinical models
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