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Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin and a potent antimicrotubule agent. It inhibits tubulin polymerization, disrupts microtubule organization, and induces mitotic arrest, and is supplied as a solid research reagent for in vitro and in vivo studies.
Potent tubulin inhibitor with low-nanomolar activity in tumor cell lines.
High purity suitable for research applications.
Supplied as a solid powder for solution preparation in DMSO or aqueous buffers.
Recommended solvent and formulation guidance provided for in vitro and in vivo use.
Store sealed at 4°C; solutions stable at -80°C for long-term storage.
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Taltobulin hydrochloride is the hydrochloride salt of taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin that functions as a potent tubulin (microtubule) inhibitor for preclinical cancer research and ADC payload development.
Potent tubulin inhibitor that disrupts microtubule organization.
Exhibits low-nanomolar in vitro activity (median IC50 ~1.7 nM).
Demonstrated in vivo activity in mouse xenograft models (examples: 1.6 mg/kg i.v., 3 mg/kg p.o.).
Supplied as a white to off-white solid for research use.
Storage: solid at 4°C, sealed and protected from moisture; solutions stored at -80°C or -20°C for limited durations.
High reported purity (~99.3%) suitable for biological studies.
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Taltobulin (hydrochloride) is the hydrochloride salt of taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin that acts as a potent tubulin inhibitor for research use.
hydrochloride salt form suitable for research applications.
potent tubulin inhibitor and antimicrotubule agent.
molecular weight 510.11 g/mol.
chemical formula C27H44ClN3O4.
high purity (99.3% by LC-MS).
physical form: white to off-white solid.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin and a potent antimicrotubule agent used in research. It inhibits tubulin polymerization, disrupts microtubule organization, and induces mitotic arrest and apoptosis.
Potent tubulin inhibitor for research applications
High purity (typically 99.34%)
Supplied as a white to off-white solid
Available in multiple pack sizes, including 50 mg
Used in vitro and in vivo to assess antimitotic activity
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More