Organosulfur Compounds
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Cayman Chemical Diallyl Trisulfide
An organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation.
Cayman Chemical Diallyl Trisulfide
An organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation.
Medchemexpress LLC 4-methoxyphenyl isothiocyanate | 2284-20-0 | MFCD00011676 | 165.21 g/mol | C8H7NOS | 1 G
4-Methoxyphenyl isothiocyanate is an organic isothiocyanate reagent used in biochemical research to evaluate antioxidant properties and cholinesterase interactions. It exhibits measurable radical-scavenging activity and partial inhibition of cholinesterase enzymes, and is supplied in small laboratory pack sizes for research applications.
- CAS number 2284-20-0.
- Molecular formula C8H7NOS; molecular weight 165.21 g/mol.
- Reported antioxidant activity: DPPH IC50 = 1.25 mM; ORAC = 11.7 mM Trolox equivalents.
- Partial cholinesterase inhibition: acetylcholinesterase ≈30.4%; butyrylcholinesterase ≈17.9%.
- Available pack sizes: 1 g, 5 g, 10 g, 50 g.
- Appearance: colorless to light yellow; solid-liquid mixture.
AdipoGen Ozagrel
Chemical. CAS 82571-53-7. Formula C13H12N2O2. MW 228.2. Synthetic. Ozagrel, an antithrombic drug, is a potent and selective TXA Synthase thromboxane A2 TXAS inhibitor. Acts as a selective inhibitor of TXAS with an IC50=11nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke, and antihypertensive effects in spontaneously hypertensive rats.
AdipoGen PK 11195
Chemical. CAS 85532-75-8. Formula C21H21ClN2O. MW 352.9. Selective peripheral benzodiazepine antagonist. Apoptosis enhancer. Glucose-induced insulin secretion inhibitor. Induces mitochondria cytochrome c release. Anticancer compound. Antiproliferative. Pharmacological tool in autophagy.
AdipoGen YC-1
Chemical. CAS 170632-47-0. Formula C19H16N2O2. MW 304.4. Nitric oxide NO independent, superoxide-sensitive soluble guanylyl cyclase sGC activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
AdipoGen Necrostatin-5 Nec-5
Chemical. CAS 337349-54-9. Formula C19H17N3O2S2. MW 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective