Organosulfur Compounds
Cayman Chemical Sulindac sulfone, Purity: ≥98%, CAS: 59864-04-9, 10 mg
An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats; inhibits aldose reductase (IC50 = 367 nM) in vitro
Medchemexpress LLC Benzenepropanoic acid, 4-[[4-(2-chlorophenyl)-2-thiazolyl]methoxy]-2-methyl- | 1050506-87-0 | 97.1% | C20H18ClNO3S | 1 ML
GPR120 modulator 2 is a chemical compound with a molecular formula of C20H18ClNO3S and a molecular weight of 387.88. This compound is a white to off-white solid and has a purity of 97.11% as determined by HPLC, with its mass spectrometry consistent with its structure.
- Molecular formula: C20H18ClNO3S
- Molecular weight: 387.88
- Appearance: White to off-white solid
- Purity (HPLC): 97.11%
- Mass spectrometry consistent with structure
Medchemexpress LLC IL-17A modulator-3 | 2467732-95-0 | 99.37% | 639.80 | 25 MG
IL-17A modulator-3 (compound 253) is an IL-17A modulator that inhibits IL-17A/A with an IC50 value of less than 10 μM. This compound is suitable for research into inflammation, cancer, and autoimmune diseases.
- Inhibits IL-17A/A with an IC50 value of less than 10 μM
- Used for research on inflammation, cancer, and autoimmune diseases
- Molecular weight: 639.80
- Appearance: White to off-white solid
Medchemexpress LLC (R)-IL-17 modulator 4 | 2446804-29-9 | 99.6% | C27H34N6O2 | 1 ML
(R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4. It is a proagent of IL-17 modulator 1, which is an orally active, highly efficacious IL-17 modulator. This product is promising for research into IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It is for research use only and not sold to patients.
- R-enantiomer of IL-17 modulator 4
- Functions as a proagent of IL-17 modulator 1
- Orally active and highly efficacious IL-17 modulator
- Potentially useful for research into IL-17A mediated diseases
- Supports studies on inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome
- For research use only
- High purity of 99.6%
- Molecular weight of 474.60
- Chemical formula C27H34N6O2
- Solid appearance
- Off-white to gray color
- Targets IL-17
Medchemexpress LLC Kv3.1 modulator 2 | 99.8% | 437.88 | 50 MG
Kv3.1 modulator 2 (compound 4) is a Kv3.1 channels modulator with an EC50 value of 68 nM. This modulator is suitable for laboratory research and studies involving Kv3.1 channels.
- Functions as a Kv3.1 channels modulator
- Has an EC50 value of 68 nM
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 25 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. This compound induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes, and inhibits tumor growth in CDX mice models. It is suitable for cancer research, including leukemia.
- Potent and selective CDK9 inhibitor (IC50 = 5.9 nM)
- Inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes (e.g., MYC and Mcl1)
- Inhibits tumor growth in CDX mice models
- High selectivity over CDK1 and CDK2
- Does not inhibit hERG channel activity at concentrations up to 30 μM
- Demonstrates a good safety profile in animal models
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 100 MG
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site with an EC50 of 8.43 ± 3.82 μM. It has a molecular weight of 408.89, appears as a solid with a white to off-white color, and is for research use only.
- Enhances GLP-1 binding to GLP-1R
- Allosteric modulator
- Molecular weight of 408.89
- Appears as a solid
- White to off-white color
- For research use only
Medchemexpress LLC Kv3.1 modulator 2 | 3035827-42-7 | 99.8% | 437.88 | 5 MG
Kv3.1 modulator 2 (compound 4) is a Kv3.1 channels modulator with an EC50 value of 68 nM. This product is for research use only and is not sold to patients.
- Kv3.1 channels modulator
- EC50 value of 68 nM
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 10 UL
Cytochrome P450 24A1 Antibody (YA2121) is a non-conjugated, Rabbit-derived IgG monoclonal antibody, specifically designed to target Cytochrome P450 24A1. It is intended for research use only.
- Host: Rabbit
- Clonality: Recombinant, Monoclonal
- Species reactivity: Human
- Isotype: IgG
- Conjugation: Non-conjugated
- Formulation: Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Storage & stability: Stored at -20°C for 1 year, avoiding repeated freeze/thaw cycles.
- Applications: Western blot (WB) with a dilution ratio of 1:500-1:1000.
- Function: This cytochrome P450 monooxygenase is crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol through C24- and C23-oxidation pathways.
- Subcellular localization: Mitochondrion
Aobchem Allyl(3 5-dimethoxyphenyl)sulfane | 97% | C11H14O2S | 500mg
Allyl(3 5-dimethoxyphenyl)sulfane | 97% | C11H14O2S | 500mg
Cayman Chemical Sulindac, Purity: ≥98%, CAS: 38194-50-2, 5 g
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
