Organosulfur Compounds
Selleck Chemical LLC Benzyl isothiocyanate S4783-25mg
Benzyl isothiocyanate (BITC Benzoylthiocarbimide Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory anti-parasitic antibiotic antioxidative anti-atherosclerotic anti-angiogenic anti-metastatic anticancer chemotherapeutic and chemopreventive activities
Indofine Chemical THIOUREA, Products for Life Science, 62-56-6, 1 kg
THIOUREA, Products for Life Science, 62-56-6, 1 kg
eMolecules Dichloro(p-cymene)tricyclohexylphosphineruthenium(II), min. 97% | 145381-23-3 | | 1g
Strem Chemicals | Dichloro(p-cymene)tricyclohexylphosphineruthenium(II), min. 97% | 1g | 321338666 | 44-0430 | 97.000 | 145381-23-3 | | 586.630 | C28H47Cl2PRu
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Chem-Impex International, Inc. 2-Mercapto-5-nitropyridine | MFCD00030890 | 5G
2-Mercapto-5-nitropyridine, MFCD00030890, 5G
eMolecules 6-Benzyl-2-thiouracil | 6336-50-1 | MFCD00023224 | 500mg
Toronto Research Chemicals | 6-Benzyl-2-thiouracil | 500mg | 601590344 | B315158 | | 6336-50-1 | MFCD00023224 | 218.270 | C11H10N2OS
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eMolecules (S)-2-(2-(METHYLTHIO)PHENYL)PYRROLIDINE | 1213556-30-9 | MFCD08057893 | 0.25g
AstaTech | (S)-2-(2-(METHYLTHIO)PHENYL)PYRROLIDINE | 0.25g | 624127512 | Y11925 | 95.000 | 1213556-30-9 | MFCD08057893 | 193.310 | C11H15NS
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Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 25 MG
NX-2127 is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (BTK). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) and stimulates T cell activation.
- Inhibits proliferation of BTK-C481S mutant TMD8 cells
- Catalyzes degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Potently degrades BTK in cynomolgus monkeys in vivo
- Leads to dose-proportional exposure in plasma
- Results in superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice
