Organosulfur Compounds
TARGETMOL CHEMICALS INC CALCIUM CHANNEL-MODULATO 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Calcium channel-modulator-1 is a calcium channel-modulator (IC500.8 uM) with specialisation to block aortic constriction. purity: 99%
AdipoGen Thapsigargin
Chemical. CAS 67526-95-8. Formula C34H50O12. Molecular Weight 650.75. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs IC50 values are cell type-dependent and range from ~2-80 nM. Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
AdipoGen Thapsigargin
Chemical. CAS 67526-95-8. Formula C34H50O12. Molecular Weight 650.75. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs IC50 values are cell type-dependent and range from ~2-80 nM. Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
AdipoGen Caroverin
Chemical. CAS 23465-76-1. Formula C22H27N3O2. MW 365.47. Synthetic. Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.
AdipoGen Caroverin
Chemical. CAS 23465-76-1. Formula C22H27N3O2. MW 365.47. Synthetic. Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.
AdipoGen R-Roscovitine
Chemical. CAS 186692-46-6. Formula C19H26N6O. MW 354.5. Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase IC50 = 450 nM, CDK2 IC50 = 700 nM and CDK5/p35 IC50 = 160 nM. Inhibits M phase promoting factor MPF kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways10. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.