Phenylpropanoids and polyketides
Medchemexpress LLC Diphenyl Blue | 72-57-1 | 100 G
Diphenyl Blue is a cell active dye commonly used for identifying dead cells and testing cell membrane integrity and cell viability. It serves as a method for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them blue, while normal living cells with intact cell membranes reject the dye. Macrophages can phagocytose Diphenyl Blue, allowing it to be used as a living stain for these cells.
- Cell active dye
- Identifies dead cells
- Tests cell membrane integrity
- Tests cell viability
- Suitable for tissue and cell culture
- Stains deactivated or damaged cells blue
- Rejected by living cells with intact membranes
- Can be used as a living stain for macrophages
Medchemexpress LLC Phlorizin | 60-81-1 | 99.9% | 436.41 | 5 G
Phlorizin is a non-selective SGLT inhibitor that acts on hSGLT1 and hSGLT2. It also functions as a Na+/K+-ATPase inhibitor.
- Non-selective SGLT inhibitor.
- Inhibits hSGLT1 and hSGLT2.
- Na+/K+-ATPase inhibitor.
- Decreases blood glucose levels.
- Prevents nerve fiber decrease and retinal abnormalities.
Medchemexpress LLC Cresyl diphenyl phosphate | 26444-49-5 | MFCD00014920 | 97.0% | 340.31 g·mol⁻¹ | C19H17O4P | 100 G
Cresyl diphenyl phosphate is an organophosphate research chemical (CAS 26444-49-5) used in biochemical and developmental biology studies; it disrupts lipid homeostasis in zebrafish embryos. The material is supplied as a colorless to light yellow liquid with a reported purity of 97.0% and a molecular weight of 340.31 g·mol⁻¹.
- Research-grade organophosphate for laboratory studies.
- Disrupts lipid homeostasis in zebrafish embryos, useful for developmental assays.
- High analytical purity suitable for biochemical and assay applications.
- Supplied as a liquid with defined storage recommendations to maintain stability.
- Provided with documented safety and handling guidance for research use only.
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 5mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Medchemexpress LLC AKT-IN-6 | 1430056-54-4 | 99.1% | 389.43 | 1 ML
AKT-IN-6 is a potent Akt inhibitor that targets Akt1, Akt2, and Akt3 with IC50s below 500 nM. Akt is a central node in cell signaling, and its aberrant activation is linked to various complex diseases, including type-2 diabetes and cancer.
- Potent Akt inhibitor
- Targets Akt1, Akt2, and Akt3
- Suitable for research applications
Medchemexpress LLC Phloretin | 60-82-2 | 99.92% | 274.27 | 50 G
Phloretin is a flavonoid extracted from *Malus pumila Mill.* that possesses anti-inflammatory activities. It is also a specific, competitive, and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 and Human erythrocyte GLUT1 with IC50 values of 49 μM and 61 μM, respectively. It has potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.
- Possesses anti-inflammatory activities
- Inhibits SGLT1 and SGLT2
- Inhibits Yeast-made GLUT1 and Human erythrocyte GLUT1
- Potential for treating rheumatoid arthritis and allergic airway inflammation
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 1g
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Apexbio Technology LLC Troxerutin 7085-55-4 5g
Troxerutin (CAS 7085-55-4) is a bioactive small molecule known to exhibit protective effects against gamma radiation (GR)-induced DNA damage It promotes DNA repair mechanisms thereby reducing radiation-related single- and double-strand breaks Experimentally Troxerutin (1 mM) decreased GR-triggered micronucleus formation in human lymphocytes by approximately 41% In mouse models intraperitoneal administration before or after irradiation (up to 175 mg/kg) minimized micronucleus frequency in reticulocytes and mitigated DNA strand breaks in leukocytes and bone marrow cells with dosage-dependent results Its properties make Troxerutin relevant for radiation biology research particularly in genomic stability and radioprotection studies
Apexbio Technology LLC Genistein(Synonyms: 4',5,7-Trihydroxyisoflavone, Genisteol, Prunetol, Sophoricol, Differenol A), 10mM (in 1mL DMSO), CAS: 446-72-0.
Genistein (CAS 446-72-0) is an isoflavonoid compound that selectively inhibits protein tyrosine kinases enzymes implicated in signaling pathways associated with oncogenic activity and cellular proliferation Genistein inhibits tyrosine kinase activity with an IC50 of approximately 8 M In NIH-3T3 cell assays genistein suppresses epidermal growth factor (EGF)-mediated mitogenesis (IC50 12 M) and insulin-mediated effects (IC50 19 M) additionally inhibiting EGF-induced activation of S6 kinase at a concentration of 6 15 M In animal models oral administration of genistein demonstrates dose-dependent inhibition of prostate adenocarcinoma development highlighting its utility in cancer biology research and potential chemopreventive applications