Phenylpropanoids and polyketides
Medchemexpress LLC (-)-Epicatechin gallate (standard) | 1257-08-5 | 442.37 | 1 MG
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM, and is a GLUT1 and GLUT5 inhibitor, decreasing cell growth of GLUT5-expressing hxt 0 yeast cells.
- Targets: COX, autophagy, virus protease, GLUT
- Research areas: Infection, cancer
- Structural classification: Flavonoids, flavanols, phenols, polyphenols
- Source classification: *Camellia sinensis* (L.) O. Ktze. plants, Theaceae
Medchemexpress LLC Brepocitinib (P-tosylate) | 2140301-96-6 | 100.0% | 561.60 | 1 ML
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It inhibits JAK1 with an IC50 of 17 nM and TYK2 with an IC50 of 23 nM. It also inhibits JAK2 with an IC50 of 77 nM and JAK3 with an IC50 of 6.49 μM. This compound demonstrates in vitro efficacy in inhibiting various STAT pathways and in vivo efficacy by reducing paw volume in an arthritis model.
- Potent dual inhibitor of JAK1 and TYK2
- Specific inhibition of JAK2 and JAK3 at higher concentrations
- In vitro efficacy in inhibiting STAT pathways
- In vivo efficacy in an animal model of arthritis
- Solid, white to off-white color
- Intended for research purposes only
Medchemexpress LLC Myricetin-3-O-rutinoside | 41093-68-9 | 25 MG
Myricetin-3-O-rutinoside is a natural product isolated from Picea abies. It has demonstrated antineuroinflammatory activity in human BV2 cells by inhibiting LPS-induced NO production after 24 hours, with an IC50 of 74.74 μM.
- Natural product
- Isolated from Picea abies
- Light yellow to yellow solid appearance
- Molecular weight: 626.52
- Formula: C27H30O17
- Purity: 96.98%
- Soluble in ethanol (25 mg/mL)
- For research use only
- Exhibits antineuroinflammatory activity
Cayman Chemical ApIgenIn 7-glucosIde 25mg
A flavonoid with anti-inflammatory and anxiolytic activities; inhibits LPS-induced nitric oxide production in RAW 264.7 cells from 0.16-10 μM; reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury at 10 mg/kg; increases the number of entries and the time spent in the open arms of the elevated plus maze in rats
Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 1 MG
AZP-531 is an analogue of unacylated ghrelin for research use, designed to improve glycaemic control and reduce weight. It shows survival effects on pancreatic β-cells and human pancreatic islets, and is highly stable in human plasma in vitro with no degradation after one day at 37°C.
- Exhibits survival effects on pancreatic β-cells and human pancreatic islets.
- Stable in human plasma in vitro at 37°C for one day.
- Prevents high-fat diet-induced weight gain, proinflammatory effects, and prediabetic metabolic state in mice.
- Stimulates mitochondrial function markers in brown adipose tissue.
- Well-tolerated in clinical trials; improves glucose without increasing insulin.
- Reduces mean body weight and HbA1c in clinical trials.
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 10 MG
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. It exerts survival effects on pancreatic b-cells and human pancreatic islets comparable to unacylated ghrelin (UAG). It is very stable in human plasma in vitro with no degradation observed after 1 day of incubation at 37°C.
- Prevents body weight increase caused by a high-fat diet in mice
- Prevents high-fat diet-induced proinflammatory effects
- Stimulates mitochondrial function markers in brown adipose tissue
- Prevents the development of a prediabetic metabolic state
- Prevents a high-fat diet-induced increase in acyl ghrelin levels
- Significantly improves glucose concentrations without increasing insulin levels
- Decreases mean body weight by 2.6 kg (vs 0.8 kg for placebo)
- Reduces HbA1c by 0.4% (vs 0.2% for placebo)
Apexbio Technology LLC Coumarin 6 38215-36-0 100mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Selleck Chemical LLC Tyrphostin AG 1296
Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0 3-0 5 M no activity to EGFR Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12 3 M and 1 8 M in Swiss 3T3 cells Tyrphostin AG1296 induces dramatic apoptosis in A375R cells
Medchemexpress LLC 2-methoxycinnamaldehyde | 1504-74-1 | 99.0% | 162.19 g/mol | C10H10O2 | 5 G
2-Methoxycinnamaldehyde is a natural small-molecule aldehyde used for biochemical and cell-based research. It has reported activity including inhibition of topoisomerase I/II and NF-κB signaling, induction of apoptosis, and effects on mitochondrial and lysosomal function. The material is supplied as a white to yellow solid with typical purity near 98.95% and a molecular weight of 162.19 g/mol. Storage recommendations include keeping the solid under nitrogen at -20°C; in solution, store at -80°C for up to 6 months or at -20°C for up to 1 month.
- Research-grade small molecule for biochemical assays.
- Reported biological activities include apoptosis induction and signaling inhibition.
- High chemical purity suitable for analytical and preparative use.
- Solid physical form facilitates handling and storage.
- Storage guidance provided for long-term and in-solution stability.