Phenylpropanoids and polyketides
TARGETMOL CHEMICALS INC Daidzin 500MG
Also available in 1 mL, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities. Purity 99.43%
Medchemexpress LLC p-Coumaric Acid Ethyl Ester | 7362-39-2 | 25 MG
p-Coumaric Acid Ethyl Ester is a non-competitive, reversible inhibitor of tyrosinase, utilized in the development of medicines, cosmetics, and fruit preservation products. It boasts a purity of 99.19% and a molecular weight of 192.21, presenting as a light yellow to light brown solid. This compound also exhibits anti-platelet activity.
- Non-competitive, reversible tyrosinase inhibitor
- IC50 of 4.89 μg/mL and Ki of 1.83 μg/mL against tyrosinase
- Quenches intrinsic fluorescence of the enzyme
- Alters L-tyrosine binding affinity through conformational changes in tyrosinase
- Does not bind to the enzyme's copper ion
- Shows anti-platelet activity in rabbit platelet-rich plasma (IC50 = 130.4 μM)
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | MFCD00016762 | 25 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It functions as a metabolite and is known for its anti-allergic and anti-inflammatory properties. This chalcone is also noted for inducing apoptosis and inhibiting the production of MCP-1 and NO, as well as exhibiting anticancer activity against glioblastoma. This product is intended for research use only.
- Intermediate in flavonol biosynthesis
- Induces apoptosis
- Inhibits the production of MCP-1 and NO
- Exhibits anticancer activity against glioblastoma
- Possesses anti-inflammatory properties
- Possesses anti-allergic properties
- Functions as a metabolite
- Intended for research use only
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC Naringenin 480-41-1 10mM (in 1mL DMSO)
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Medchemexpress LLC Naringin Dihydrochalcone | 18916-17-1 | 99.2% | 582.55 | 5 G
Naringin Dihydrochalcone is an artificial sweetener synthesized from naringin, a flavanone glycoside naturally found in citrus fruits like tomatoes and grapefruits. It demonstrates various biological properties, including antioxidant, anti-inflammatory, and antiapoptotic effects, and is known to suppress the NF-κB signaling pathway.
- Artificial sweetener.
- Derived from naringin, a flavanone glycoside.
- Exhibits antioxidant, anti-inflammatory, and antiapoptotic activities.
- Suppresses NF-κB signaling pathway.
- Inhibits high glucose-induced proliferation and oxidative stress in HBZY-1 cells.
- Induces autophagic cell death in AGS cancer cells.
- Protects PC12 cells from neurotoxicity and enhances antioxidant defense.
- Alleviates renal injury, collagen deposition, and fibrosis in diabetic rats.
- Improves learning, memory, and insulin signaling in high-fat diet-induced obese mice.
Medchemexpress LLC m-Coumaric acid (Standard) | 588-30-7 | 99.91% | 164.16 | 25 MG
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid, intended for research and analytical applications. It is a polyphenol metabolite from caffeic acid, formed by gut microflora, with its amount in human biofluids being diet-dependent. m-Coumaric acid is also a BBB-penetrant metabolite of chlorogenic acid.
- Stimulates the cerebral nerves in vitro.
- Can evoke neurite outgrowth in hippocampal neuronal cells.
- Can promote neuronal differentiation.
- Increases spontaneous locomotor activity in mice by acting on the central nervous system.
- Inhibits the oxidation of L-dopa by epidermis tyrosinase.
- Attenuates non-catalytic protein glycosylation in retinas of diabetic rats.
Medchemexpress LLC 3-Methylcinnamic acid | 3029-79-6 | 99.8% | C10H10O2 | 10 G
3-Methylcinnamic acid is a drug intermediate used for the synthesis of various active compounds.
- Used as a drug intermediate
- Suitable for synthesis of various active compounds
- High purity of 99.77%
Cayman Chemical 3azido7hydroxy Coumarin
A click-reactive fluorescent dye; Upon CuAAC in a biological system, a fluorescent product is produced that displays excitation/emission maxima of 404 and 477 nM, respectively; has been used for spatially restricted metabolite labeling and the detection of foodborne pathogens
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
Selleck Chemical LLC Cinnamyl acetate
Cinnamyl acetate (3-Phenylallyl acetate) is a naturally occuring compound used as a flavouring agent