Phenylpropanoids and polyketides
Selleck Chemical LLC Esculetin S4711-100mg
Esculetin (Cichorigenin Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema anti-inflammatory and anti-tumour effects It inhibits lipoxygenases (LOs)
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 10mM (in 1mL DMSO)
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability
Medchemexpress LLC Linarin (buddleoside) | 480-36-4 | MFCD00151178 | 98.0% | 592.55 | C28H32O14 | 10 MG
Linarin (buddleoside) is a naturally occurring flavonoid glycoside and an orally active, selective acetylcholinesterase (AChE) inhibitor. It has reported anti-inflammatory, antioxidant, sedative, bone differentiation, antitumor, antibacterial, and antiviral activities and is used in research on nervous system disorders, osteoporosis, and cancer.
- Natural flavonoid glycoside, also known as buddleoside.
- Selective acetylcholinesterase (AChE) inhibitor, orally active.
- CAS 480-36-4; formula C28H32O14; molecular weight 592.55.
- Purity typically 98.0% as supplied.
- White to off-white solid; soluble in DMSO (≈250 mg/mL).
- Storage: protect from light; short-term 4°C; in solution -20°C to -80°C as specified.
- Supplied in small research quantities suitable for in vitro and in vivo studies.
TARGETMOL CHEMICALS INC HX 531 10MG
Also available in 1 mg 5 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. HX 531 is a potent antagonist of the retinoid X receptor with an IC50 value of 18 nM. purity: 99%
Medchemexpress LLC Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 1 ML
The product is a potent inhibitor of both mTORC1 and mTORC2 complexes, affecting the PI3K/AKT/mTOR pathway. It demonstrates the ability to reduce endothelial cell proliferation and induce apoptosis in vitro, as well as exhibit antitumor activity in various cancer cell lines and mouse models. This compound interferes with the pathway through the dissociation of mTOR complex 1 and mTOR complex 2, leading to decreased phosphorylation of substrates, cell growth inhibition, and cell death.
- Potent inhibitor of mTORC1 and mTORC2 complexes.
- Inhibits VEGF-driven and bFGF-driven endothelial cell proliferation.
- Induces endothelial cell apoptosis.
- Reduces Akt activity in various cancer cell lines.
- Demonstrates antitumor activity in glioblastoma, prostate, and breast cancer models.
- Causes cell growth inhibition and death in cancer cells.
eMolecules 4-Methylesculetin | 529-84-0 | MFCD00006859 | 1g
Combi-Blocks | 4-Methylesculetin | 1g | 415500297 | QC-7742 | 95.000 | 529-84-0 | MFCD00006859 | 192.170 | C10H8O4
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Selleck Chemical LLC 4-Methylesculetin S4966-25mg
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 20mg
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Indofine Chemical Linarin With Hplc, 5 Mg
LINARIN with HPLC, Flavonoid & Coumarins, 480-36-4, 98.5% by HPLC, 5 mg
Apexbio Technology LLC Rifabutin 72559-06-9 10mM (in 1mL DMSO)
Rifabutin is an antimycobacterial agent derived from rifamycin S belonging to the ansamycin antibiotic class It acts by binding to bacterial RNA polymerase inhibiting RNA synthesis and thus suppressing mycobacterial replication Rifabutin exhibits inhibitory activity against Mycobacterium tuberculosis strains with reported minimum inhibitory concentrations (MICs) typically ranging between 0 125 and 0 25 g/ml Due to its bacterial membrane affinity mediated through electrostatic interactions with phospholipid headgroups Rifabutin has attracted research interest in tuberculosis treatment models Experimentally its administration in murine tuberculosis infection models reduced bacterial load in lung liver and spleen tissues It is additionally investigated in clinical contexts particularly to manage tuberculosis infections in immunocompromised hosts including organ transplant recipients