Sulfamethoxazole-d4 (Ro 4-2130-d4) is a deuterium-labeled version of Sulfamethoxazole, a sulfonamide antibiotic with broad antibacterial activity. It inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (PABA) to affect dihydropteroate synthetase and dihydropteroate reductase. This compound is used in research for conditions such as urinary tract infections (UTIs), prostatitis, and bronchitis. Deuterium labeling incorporates stable heavy isotopes into the drug molecule, which can serve as a tracer for quantitation during drug development and potentially affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.