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Commonly in liquid form and available in various chemical compositions, solvents are substances that dissolve solutes to form solutions. The amount and type of solute that a solvent can dissolve is dependent upon temperature and polarity.
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Metolazone-d7 is deuterium labeled Metolazone, primarily used to treat congestive heart failure and high blood pressure. This compound can be used as a tracer and as an internal standard for quantitative analysis. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Used as a tracer
Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Deuterium substitution impacts pharmacokinetics
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Metolazone-d7 is deuterium-labeled Metolazone, primarily used to treat congestive heart failure and high blood pressure. Stable heavy isotopes have been incorporated into this drug molecule for use as tracers in drug development, with deuteration potentially affecting pharmacokinetic and metabolic profiles.
Molecular weight: 372.88
Formula: C16H9D7ClN3O3S
Unlabeled CAS: 17560-51-9
Appearance: Solid
Color: White to off-white
Shipped at room temperature (continental US)
Can be used as a tracer
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Solubility in DMSO: ≥ 100 mg/mL
Solubility in H2O: 0.67 mg/mL (requires ultrasonic)
Storage (powder): -20°C for 3 years, 4°C for 2 years
Storage (in solvent): -80°C for 6 months, -20°C for 1 month
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Metolazone-d7 is deuterium labeled Metolazone, primarily used to treat congestive heart failure and high blood pressure. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Used as a tracer
Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
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Nortriptyline hydrochloride (CAS 894-71-3) is a dibenzocycloheptene-derived tricyclic antidepressant that inhibits monoamine reuptake transporters It selectively blocks the norepinephrine transporter (NET) with a Ki of 3 4 nM and inhibits the serotonin transporter (SERT) with a Ki of 161 nM thereby increasing synaptic concentrations of these neurotransmitters in the central nervous system In vitro nortriptyline dose-dependently suppresses spontaneous migration and chemotaxis of human polymorphonuclear cells In vivo studies in rodents indicate partial blockade of noradrenaline depletion in nerve terminals at higher doses Nortriptyline is frequently employed in research on monoaminergic neurotransmission and antidepressant pharmacology
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Nortriptyline hydrochloride (CAS 894-71-3) is a dibenzocycloheptene-derived tricyclic antidepressant that inhibits monoamine reuptake transporters It selectively blocks the norepinephrine transporter (NET) with a Ki of 3 4 nM and inhibits the serotonin transporter (SERT) with a Ki of 161 nM thereby increasing synaptic concentrations of these neurotransmitters in the central nervous system In vitro nortriptyline dose-dependently suppresses spontaneous migration and chemotaxis of human polymorphonuclear cells In vivo studies in rodents indicate partial blockade of noradrenaline depletion in nerve terminals at higher doses Nortriptyline is frequently employed in research on monoaminergic neurotransmission and antidepressant pharmacology
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Nortriptyline hydrochloride (CAS 894-71-3) is a dibenzocycloheptene-derived tricyclic antidepressant that inhibits monoamine reuptake transporters It selectively blocks the norepinephrine transporter (NET) with a Ki of 3 4 nM and inhibits the serotonin transporter (SERT) with a Ki of 161 nM thereby increasing synaptic concentrations of these neurotransmitters in the central nervous system In vitro nortriptyline dose-dependently suppresses spontaneous migration and chemotaxis of human polymorphonuclear cells In vivo studies in rodents indicate partial blockade of noradrenaline depletion in nerve terminals at higher doses Nortriptyline is frequently employed in research on monoaminergic neurotransmission and antidepressant pharmacology
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More