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rel-VU6021625 is the relative configuration of VU6021625 (HY-160440A). VU6021625 is a potent and selective mAChR M4 antagonist with IC50 values of 0.44 nM for human M4 and 57 nM for rat M4. It is for research use only.
Potent and selective mAChR M4 antagonist
Available in solid form or as a solution in DMSO
Suitable for in vitro and in vivo dissolution protocols
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Ulipristal acetate (126784-99-4) is a selective progesterone receptor modulator (SPRM) targeting progesterone receptors It is designed to modulate receptor-mediated signaling thereby regulating endometrial tissue proliferation and fibroid cell growth Ulipristal acetate exerts its biological activity primarily through reversible inhibition of progesterone-dependent signaling pathways Based on these pharmacological properties ulipristal acetate holds research potential in studies of progesterone signaling pathways uterine physiology hormonal regulation mechanisms and benign gynecological conditions such as uterine myoma
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Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
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Vitamin D-Binding Protein conjugated to near-infrared fluorescent CF740 can be used to stain monomeric G-actin in fixed and permeabilized cells The conjugate has been optimized for immunofluoresnce and is is supplied at 100 ug/mL CF740 has an Ex/Em of 742/767 nm
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Vitamin C (CAS 50-81-7) is a water-soluble vitamin studied extensively in biomedical contexts for its potential anticancer and antiviral activities Mechanistically vitamin C exerts antiproliferative effects on tumor cells and promotes apoptosis as demonstrated in murine colon cancer (CT26) cells At concentrations of 100-200 g/ml vitamin C inhibited proliferation significantly higher levels (200-1000 g/ml) induced apoptosis dose-dependently In vivo studies showed vitamin C treatment reduced tumor volume markedly in CT26 and 4T1 tumor-bearing BALB/c mouse models These findings highlight vitamin C s utility in cancer research as a therapeutic adjunct and investigational agent
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