Triterpenoids
Apexbio Technology LLC Limonin 1180-71-8 100mg
Limonin (CAS 1180-71-8) is a natural limonoid with inhibitory activities against carcinogenesis and HIV-1 replication It modulates apoptotic signaling pathways to induce apoptosis and suppress HIV-1 replication In in vitro studies limonin demonstrates dose-dependent inhibition of HIV-1 replication with an EC50 of approximately 60 M in human peripheral blood mononuclear cells (PBMCs) and monocyte/macrophage (M/M) cells In human hepatoma HepG2 cells limonin induces apoptosis by affecting relevant signaling pathways Animal studies show that limonin reduces tumor burden and incidence in DMBA-treated Syrian hamsters and inhibits colon adenocarcinoma development in azoxymethane (AOM)-treated rats Based on these pharmacological properties limonin holds research potential in HIV antiviral mechanisms and chemically-induced carcinogenesis models
Apexbio Technology LLC Glycyrrhetinic acid 1449-05-4;471-53-4 20mg
Glycyrrhetinic acid (CAS 1449-05-4) is a small-molecule inhibitor targeting 11 -hydroxysteroid dehydrogenase It is designed to modulate enzymatic activity thereby influencing corticosteroid metabolism and cortisol bioavailability Glycyrrhetinic acid exerts its biological activity primarily through inhibition of 11 -hydroxysteroid dehydrogenase Based on these pharmacological properties glycyrrhetinic acid holds research potential in anti-inflammatory antiviral and hepatoprotective applications
Medchemexpress LLC Limonin | 1180-71-4 | >98% | 470.51 | 1 ML
Limonin is a natural product isolated from Dictamnus dasycarpus. It is known for its antiviral and antitumor activities, inhibiting HIV-1 and inducing apoptosis in human colon adenocarcinoma cells. In vitro studies show limonin's anti-proliferation effects on colon adenocarcinoma cells and pancreatic cancer cell lines, while in vivo research demonstrates its ability to significantly inhibit tumor growth in xenograft mouse models.
- Inhibits HIV-1 with an EC50 of 60.0 μM.
- Induces apoptosis in human colon adenocarcinoma cells with an IC50 of 54.74 μM.
- Shows anti-proliferation effects on Caco-2 and HCT-116 cells.
- Suppresses cell migration and invasion in HCT-116 cells.
- Activates Erk and p38 MAPK pathways.
- Significantly inhibits tumor growth in HCT-116 xenograft mouse models.
Selleck Chemical LLC Ursonic acid S3902-25mg
Ursonic acid (Prunol Malol beta-Ursolic acid NSC4060 CCRIS 7123 TOS-BB-0966) present in many plants is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives such as experimental antitumor agents Ursonic acid induces the apoptosis of human cancer cells through multiple signaling pathways
Selleck Chemical LLC Betulinic acid S3603-10mg
Betulinic acid (ALS-357 Lupatic acid Betulic acid) a pentacyclic triterpenoid from Syzigium claviflorum is a inhibitor of HIV-1 with EC50 of 1 4 M It s reported that Betulinic acid acts as a new inhibitor of NF- B Phase 1/2
Medchemexpress LLC Lup-20(29)-en-3-ol, 3-(hexadecanoate), (3β)- | 32214-80-5 | 25 MG
Lupeol palmitate is a natural compound with established antiulcer activities and a gastroprotective action.
- Natural compound
- Exhibits antiulcer activities
- Provides gastroprotective action
- Purity of 98.0%
- Molecular weight: 665.13
- Molecular formula: C46H80O2
- Appearance: White to off-white solid
- Classified as terpenoids, triterpenes, pentacyclic triterpenoids
- Derived from plants
Medchemexpress LLC Oleanolic acid | 508-02-1 | 98.0% | 456.70 | 100 MG
Oleanolic acid is a natural compound found in plants known for its anti-tumor activities. It targets autophagy, endogenous metabolites, HIV, and MAP3K, impacting pathways related to autophagy, metabolic enzymes, anti-infection, and MAPK/ERK.
- Suppresses proliferation of lung cancer cells
- Increases miR-122 abundance
- Induces autophagy in normal tissue-derived cells without cytotoxicity
- Impairs invasion and anchorage-independent growth of KRAS-transformed normal cells
- Suppresses tumor xenograft growth by inducing autophagy
- Triggers activation of MAPK pathways (p-38 MAPK, JNK, and ERK)
- Induces reactive oxygen species-dependent ASK1 activation for p38 MAPK-dependent apoptosis
Apexbio Technology LLC Limonin 1180-71-8 10mM (in 1mL DMSO)
Limonin (CAS 1180-71-8) is a natural limonoid with inhibitory activities against carcinogenesis and HIV-1 replication It modulates apoptotic signaling pathways to induce apoptosis and suppress HIV-1 replication In in vitro studies limonin demonstrates dose-dependent inhibition of HIV-1 replication with an EC50 of approximately 60 M in human peripheral blood mononuclear cells (PBMCs) and monocyte/macrophage (M/M) cells In human hepatoma HepG2 cells limonin induces apoptosis by affecting relevant signaling pathways Animal studies show that limonin reduces tumor burden and incidence in DMBA-treated Syrian hamsters and inhibits colon adenocarcinoma development in azoxymethane (AOM)-treated rats Based on these pharmacological properties limonin holds research potential in HIV antiviral mechanisms and chemically-induced carcinogenesis models
Enzo Life Sciences Betulinic acid (~95%) (500mg). CAS: 472-15-1
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Alternative name: 3beta-Hydroxy-20(29)-lupaene-28-oic acid. Purity: ≥90% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: +4°C.
Enzo Life Sciences Betulinic acid (~95%) (1g). CAS: 472-15-1
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Alternative name: 3beta-Hydroxy-20(29)-lupaene-28-oic acid. Purity: ≥90% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO. Long Term Storage: +4°C.
Cayman Chemical BetulInIc Aldehyde 25mg
A triterpenoid with diverse biological activities; active against P. falciparum (IC50 = 6.5 μg/ml) and M. tuberculosis (MIC = 25 μg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs = 128-512 and 8-512 μg/ml, respectively); inhibits dengue virus NS5 RNA-dependent RNA polymerase (IC50 = 6.1 μM) and inhibits dengue virus type 2 replication by 20 and 55% at 5 and 10 μg/ml, respectively; inhibits growth of leukemia, melanoma, neuroblastoma, and normal fibroblast cell lines (IC50s = 1.1-4.9, 9.6-10.6, 7.5-8.8, and 18.5 μM, respectively)
Medchemexpress LLC Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)- | 471-53-4 | 99.9% | 470.68 | 10 G
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
- Anti-ulcerative
- Anti-inflammatory
- Antiproliferative properties
Cayman Chemical BetulInIc Aldehyde oxIme 100mg
A derivative of betulin; active against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans, as well as L. donovani amastigotes, at 50 µM; is cytotoxic to Huh7 hepatocellular carcinoma cells at 50 µM