Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences Formic acid | 64-18-6 | MFCD00003297 | 100mL
Formic acid | Purity: ≥88% | MW:46.03 | 64-18-6 | MFCD00003297 | 100mL
Medchemexpress LLC Lcc-12 formic | 3029253-76-4 | 99.2% | 460.57 g/mol | C18H40N10O4 | 10 MG
LCC-12 formic is a research-grade small molecule probe (a dimer of metformin) used to modulate mitochondrial copper(II) and study inflammation and metabolic pathways in cellular and animal models.
- Targets mitochondrial copper(II) and reduces the NAD(H) pool.
- Reduces inflammation in mouse models of bacterial and viral infection.
- Serves as a tool to study metabolic disease, cell plasticity, and epigenetic programming.
- High purity and characterized molecular properties for reliable experimental use.
- Compatible with storage at -20°C; in solution store at -80°C for long-term stability.
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 500ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500ML
Medchemexpress LLC GZD856 formic | 2804039-78-7 | 95.4% | 578.58 g/mol | C30H29F3N6O3 | 1 ML
GZD856 formic is a research-grade small-molecule inhibitor supplied as a 10 mM solution in DMSO for laboratory use. It is provided as the formic salt in a 1 mL vial and is intended for in vitro and exploratory studies needing a pre-dissolved, characterized compound.
- Pre-formulated 10 mM solution for immediate use.
- Supplied in a 1 mL vial for small-scale experiments.
- Formic salt form to enhance solubility and stability.
- Purity determined by HPLC, reported at 95.36%.
- Molecular weight 578.58 g/mol; formula C30H29F3N6O3.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 5KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 5KG
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 25KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 25KG
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 100g
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC Zelavespib formic (PU-H71) | 00-00-0 | 97.4% | 558.39 g/mol | C19H23IN6O4S | 5 MG
Zelavespib formic is a research-grade small-molecule inhibitor of heat shock protein 90 (Hsp90), supplied as a formic acid salt for laboratory studies. It is intended for in vitro and preclinical research use only.
- Potent Hsp90 inhibitor (IC50 51 nM in MDA-MB-468 cells).
- Formic acid salt suitable for biological assays.
- Available as solid and as a 10 mM solution in DMSO.
- High purity (97.39%).
- Molecular weight 558.39 g/mol; formula C19H23IN6O4S.
- For research use only; not for human or clinical use.
Medchemexpress LLC CBI1 formic | 461.40 | 50 MG
CBI1 formic is a covalent BAX inhibitor that selectively derivatizes BAX at C126. It inhibits BAX activation by triggering ligands or point mutagenesis, and also blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic is effective in inhibiting BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.
- Covalent BAX inhibitor
- Selectively derivatizes BAX at C126
- Inhibits BAX activation by triggering ligands or point mutagenesis
- Blocks t-2-hex lipidation and oligomerization of BAX
- Inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex
- Available in 50 mg quantity
Medchemexpress LLC Ivaltinostat formic | 98.3% | 473.56 | 5 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that contains a hydroxamic acid moiety. It inhibits the deacetylation of histone H3 and tubulin, and induces the accumulation of p53. This compound promotes p53-dependent transactivation and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. It also enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil, inducing apoptosis and exhibiting anti-tumor effects. This product is intended for research use only.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Induces p53 accumulation and p53-dependent transactivation
- Enhances MDM2 and p21 (Waf1/Cip1) protein expression
- Increases sensitivity of Gemcitabine-resistant cells to chemotherapy
- Induces apoptosis and demonstrates anti-tumor effects
- Attenuates oxidative stress and inflammatory cytokines
Medchemexpress LLC CBI1 formic | 461.40 | 25 MG
CBI1 formic is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation induced by triggering ligands or point mutagenesis. CBI1 formic also blocks t-2-hex lipidation and oligomerization of BAX.
- Covalent BAX inhibitor.
- Selectively derivatizes BAX at C126.
- Inhibits BAX activation by triggering ligands or point mutagenesis.
- Blocks t-2-hex lipidation and oligomerization of BAX.
- Inhibits BAX activation induced by BH3 ligands, F116A mutagenesis, or t-2-hex.