Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.
Medchemexpress LLC Pkiota-in-2 formic | 99.04% | 402.36 | 10 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (IC50 of 2.8 nM), and also inhibits PKC-α (IC50 of 71 nM) and PKC-ε (IC50 of 350 nM). This compound is for research use only.
- Molecular weight of 402.36
- Formula: C25H23N5O3
- Appearance as a solid
- Color ranges from light yellow to yellow
- Soluble in DMSO at 100 mg/mL (248.53 mM); requires ultrasonic
- Ships at room temperature in continental US
- Store at 4°C sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Formic acid ammonium salt | 540-69-2 | MFCD00013103 | 98.5% | 63.06 | CH5NO2 | 1mL
Formic acid ammonium salt is an endogenous metabolite
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemical | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 1kg | 736631842
Formic Acid, ACS Grade | Oakwood Chemical | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 1kg | 736631842
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, >=88% | 64-18-6 | MFCD00003297 | 4X2.5L
Formic acid ACS reagent, >=88% | Purity: >=88% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 4X2.5L
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 5 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. This compound is for research use only. In vivo, it causes a dose-dependent decrease in circulating lymphocytes. In rats, at 10 mg/kg, SLB1122168 reaches a maximum concentration of 4 μM at 2 hours post-dose, maintains levels at ≥1 μM for 24 hours, and has a half-life of 8 hours.
- Potent Spns2-mediated S1P release inhibitor
- IC50 of 94 nM
- Causes a dose-dependent decrease in circulating lymphocytes
- Suitable for research applications
- Demonstrates sustained in vivo activity with levels ≥1 μM for 24 hours
- Half-life of 8 hours in rats
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 1 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II)
- Leads to a decrease in the NAD(H) pool
- Modulates inflammatory responses
- Reduces inflammation in mouse models of bacterial and viral infections
- Serves as a tool for investigating metabolic diseases
- Affects cell plasticity and epigenetic programming
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Formic Acid (Aldehyde-Free/Sequencing), Fisher BioReagents™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Formic Acid, 88%, BAKER ANALYZED™ A.C.S. Reagent, J.T. Baker™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3924754 SIGMA FORMIC ACID 98 - 100