Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3982132 FORMIC ACID 98-100 FOR HPLC L
Sigma Aldrich Fine Chemicals Biosciences Formic acid, 64-18-6, MFCD00003297, 500 mL
Linear Formula: HCOOH, Molecular Weight: 46.03, puriss., meets analytical specifications of DAC, FCC, 98.0-100%.
Hach Company Intellical™ ISENa38101 Sodium (Na⁺) Ion Selective Electrode (ISE) with Calibration Reagents Pack
The Intellical™ Sodium ISE Analysis Package contains all you need to start measuring Sodium (Na+) with your HQD meter instrument: The Intellical™ ISENA381 Sodium ISE with 1 m cable, the sodium ISAB powder pillows, 100 mg/L and 1000 mg/L sodium standard solutions.
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 20kg | 480143866
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 20kg | 480143866
Medchemexpress LLC SLB1122168 formic | 2999629-17-1 | C23H37N3O3 | 50 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. It leads to a dose-dependent decrease in circulating lymphocytes, and in rats, it achieves a maximum concentration of 4 μM at 2 hours post-dose, maintaining levels ≥1 μM for 24 hours with a half-life of 8 hours.
- Potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM
- Induces a dose-dependent decrease in circulating lymphocytes
- Relevant for research in respiratory disease, inflammation or immune system disease, pulmonary disease, and lung fibrosis
- Acts on inflammation/immunology signaling pathways, GPCR/G protein, and LPL receptor
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 100 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. It is intended for research use only and not for patient administration.
- Potent Spns2-mediated S1P release inhibitor
- Inhibitor with an IC50 of 94 nM
- Intended for research use
Covachem LCMS GRD FORMC ACID ULTPR 25ML
LCMS Grade Formic Acid (UltraPure). 25 mL Bottle. Appearance: Clear liquid. Purity: is ≥ 99%. Storage: Room Temperature. 64-18-6.
Medchemexpress LLC Lcc-12 formic | 3029253-76-4 | 99.2% | 460.57 g/mol | C18H40N10O4 | 10 MG
LCC-12 formic is a research-grade small molecule probe (a dimer of metformin) used to modulate mitochondrial copper(II) and study inflammation and metabolic pathways in cellular and animal models.
- Targets mitochondrial copper(II) and reduces the NAD(H) pool.
- Reduces inflammation in mouse models of bacterial and viral infection.
- Serves as a tool to study metabolic disease, cell plasticity, and epigenetic programming.
- High purity and characterized molecular properties for reliable experimental use.
- Compatible with storage at -20°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 50 MG
CCT367766 formic is a potent third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. This PROTAC effectively depletes pirin protein expression at low concentrations. It demonstrates a moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM. Furthermore, it shows good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. This product serves as a valuable chemical tool for researching a protein that is currently not well understood.
- Potent third-generation PROTAC.
- Targets pirin protein degradation.
- Moderate affinity for the CRBN-DDB1 complex (IC50 = 490 nM).
- Good affinity for recombinant pirin (Kd = 55 nM) and CRBN (Kd = 120 nM).
- Useful chemical tool for pirin protein studies.