Formic Acid
Newcomer Supply Decalcifying Solution, Formic Acid 5%, Aqueous, 1 gallon
Newcomer Supply Decalcifying Solution, Formic Acid, 5% Aqueous, provides a moderate rate of decalcification while maintaining excellent cellular morphology. This solution is a general purpose decalcifier and is suitable for all bone specimen types from sternal or iliac crest bone marrow biopsies (light bone) to femoral head and long bone sections (compact bone). Shelf Life is 1 year from date of manufacture. Store at 15-30°C.
Medchemexpress LLC Sj1008030 (formic) | 97.7% | 919.96 | 25 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be used for leukemia research. This compound consists of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for the research of leukemia
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, >=88% | 64-18-6 | MFCD00003297 | 100ML
Formic acid ACS reagent, >=88% | Purity: >=88% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Medchemexpress LLC Ivaltinostat formic | 98.3% | 473.56 | 5 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that contains a hydroxamic acid moiety. It inhibits the deacetylation of histone H3 and tubulin, and induces the accumulation of p53. This compound promotes p53-dependent transactivation and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. It also enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil, inducing apoptosis and exhibiting anti-tumor effects. This product is intended for research use only.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Induces p53 accumulation and p53-dependent transactivation
- Enhances MDM2 and p21 (Waf1/Cip1) protein expression
- Increases sensitivity of Gemcitabine-resistant cells to chemotherapy
- Induces apoptosis and demonstrates anti-tumor effects
- Attenuates oxidative stress and inflammatory cytokines
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 1 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II)
- Leads to a decrease in the NAD(H) pool
- Modulates inflammatory responses
- Reduces inflammation in mouse models of bacterial and viral infections
- Serves as a tool for investigating metabolic diseases
- Affects cell plasticity and epigenetic programming
Medchemexpress LLC Pkiota-in-2 formic | 99.04% | 402.36 | 10 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (IC50 of 2.8 nM), and also inhibits PKC-α (IC50 of 71 nM) and PKC-ε (IC50 of 350 nM). This compound is for research use only.
- Molecular weight of 402.36
- Formula: C25H23N5O3
- Appearance as a solid
- Color ranges from light yellow to yellow
- Soluble in DMSO at 100 mg/mL (248.53 mM); requires ultrasonic
- Ships at room temperature in continental US
- Store at 4°C sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 5 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. This compound is for research use only. In vivo, it causes a dose-dependent decrease in circulating lymphocytes. In rats, at 10 mg/kg, SLB1122168 reaches a maximum concentration of 4 μM at 2 hours post-dose, maintains levels at ≥1 μM for 24 hours, and has a half-life of 8 hours.
- Potent Spns2-mediated S1P release inhibitor
- IC50 of 94 nM
- Causes a dose-dependent decrease in circulating lymphocytes
- Suitable for research applications
- Demonstrates sustained in vivo activity with levels ≥1 μM for 24 hours
- Half-life of 8 hours in rats
Medchemexpress LLC Bisindolylmaleimide IX formic | 00-00-0 | 96.0% | 503.57 g/mol | C26H25N5O4S | 5 MG
Ro 31-8220 formic is the formic acid salt of bisindolylmaleimide IX, a potent protein kinase C (PKC) inhibitor provided for laboratory research. The compound is supplied as a small, high-purity solid with manufacturer storage and handling guidance available on the product datasheet.
- Potent PKC inhibitor with low-nanomolar activity.
- Formic acid salt for improved handling and solubility options.
- High purity (≈96.0%).
- Orange to red solid appearance.
- Supplied as a 5 mg vial for research use.
- Recommended storage: sealed, away from moisture, at -20 °C; in solvent, store at -80 °C (up to 6 months) or -20 °C (up to 1 month).
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.