Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
![eMolecules Medchem Express / EZM0414 (TFA) / 5mg / 592903606 / HY-136328 / / 2411759-92-5 / [null] / 514.522 / C24H30F4N4O4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475906.JPG-250.jpg)
eMolecules Medchem Express / EZM0414 (TFA) / 5mg / 592903606 / HY-136328 / / 2411759-92-5 / [null] / 514.522 / C24H30F4N4O4
Medchem Express / EZM0414 (TFA) / 5mg / 592903606 / HY-136328 / / 2411759-92-5 / [null] / 514.522 / C24H30F4N4O4
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
Apexbio Technology LLC cyclo(RLsKDK) TFA(Synonyms: cyclo(RLsKDK), Cyclic peptide RLsKDK, ADAM8 inhibitor peptide, Cyclo-Arg-Leu-Ser-Lys-Asp-Lys), 1mg.
Cyclo(RLsKDK) TFA is a cyclic pentapeptide inhibitor targeting the metalloproteinase ADAM8 a transmembrane protein frequently dysregulated in pathological conditions such as inflammation cancer and neurodegenerative diseases By specifically inhibiting ADAM8 enzymatic activity cyclo(RLsKDK) TFA may modulate disease-associated cellular processes This molecule holds promise as a research tool for studying ADAM8 function and as a potential therapeutic candidate in inflammatory disorders and oncology
eMolecules Ambeed / 2-Fluoro-6-methylpyridine / 5g / 552650211 / A211927 / / 407-22-7 / MFCD00041226 / 111.119 / C6H6FN
Ambeed / 2-Fluoro-6-methylpyridine / 5g / 552650211 / A211927 / / 407-22-7 / MFCD00041226 / 111.119 / C6H6FN
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 25mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways