Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC BIBP3226 TFA | 1068148-47-9 | 99.3% | 587.59 | 5 MG
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. It has been observed to display an anxiogenic-like effect.
- Potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist.
- Ki values of 1.1 nM for rNPY Y1, 79 nM for hNPFF2, and 108 nM for rNPFF.
- Induces an anxiogenic-like effect at higher doses in vivo.
- Available in 5 mg quantity.
Medchemexpress LLC NLS-StAx-h TFA | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
NLS-StAx-h TFA is a selective, cell-permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. It efficiently inhibits β-catenin-transcription factor interactions and demonstrates anti-proliferation effects on cancer cells, making it suitable for research into Wnt signaling pathways.
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation effects on cancer cells
- Reduces the viability of SW-480 and DLD-1 colorectal cancer cells by more than 80%
- Inhibits the migration of colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Wrwyar-NH2 TFA | 936.07 | 1 MG
Wrwyar-NH2 (TFA) is a control peptide.
- Control peptide for wrwycr-NH2
- Targets DNA/RNA synthesis
- Involved in the cell cycle/DNA damage pathway
Medchemexpress LLC Sar441255 TFA | 99.93% | 4866.56 (free base) | 5 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys. This product is for research use only.
- Potent unimolecular peptide
- GLP-1/GIP/GCG receptor triagonist
- Displays high potency
- Balanced activation of target receptors
- Shows positive acute glucoregulatory effects
- For research use only
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC Adrixetinib TFA | C27H25F6N5O7 | 25 MG
Adrixetinib TFA is an Axl/Mer/CSF1R inhibitor. This product is supplied as an off-white to light yellow solid, with a purity of 99.82% as determined by HPLC.
- Axl/Mer/CSF1R inhibitor
- High purity (99.82% by HPLC)
- Off-white to light yellow solid appearance
Medchemexpress LLC Gln-AMS (TFA) | 99.9% | 588.47 | 25 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor that inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is provided as a solid, white to off-white in appearance, and is stable under recommended storage conditions, making it suitable for laboratory research in metabolic enzyme, protease, anti-infection, and bacterial studies.
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Available in various quantities for research needs.
- Stable under recommended storage conditions.
- Suitable for in vitro and in vivo dissolution protocols.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride
REAGENT Trifluoroacetic anhydride
Strem, An Ascensus Company CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Medchemexpress LLC Crotamine (TFA) | 98.1% | 4883.73 | 5 MG
Crotamine TFA is a Na+ channel modulator. It is a 42 amino acid toxin cross-linked by three disulfide bridges. It has analgesic activity and also interacts with lipid membranes, showing myonecrotic activity. Crotamine can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes
- Shows myonecrotic activity
- Isolated from *Crotalus durissus terrificus* venom
Medchemexpress LLC Claramine (TFA) | 3030428-57-7 | 95.0% | 703.02 | 25 MG
Claramine TFA is a steroidal polyamine. It can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
- Steroidal polyamine
- Regulates the properties of lipid membranes
- Protects cells from various biological toxins
Medchemexpress LLC DOTA-LM3 TFA | 99.3% | 1664.18 | 5 MG
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. The LM3 component refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, which is also a somatostatin antagonist. This product is often isotopically labeled for in vivo tumor tracing, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Acts as an antagonist for somatostatin receptors
- Commonly labeled with isotopes like 177Lu or 68Ga for in vivo tumor tracing
- 68Ga-DOTA-LM3 TFA exhibits favorable biodistribution
- Shows high tumor uptake and good tumor retention
- 68Ga-DOTA-LM3 TFA has few safety concerns
- Useful for research in DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis
- Can be utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs)
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 100 UG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for ADAMTS13 assay, with excitation at 340 nm and emission at 450 nm. It is utilized as a predictive tool for thrombotic thrombocytopenic purpura. This product is a light yellow to yellow solid with a molecular weight of 8314.28 and a purity of 97.3%.
- Serves as a fluorogenic substrate for ADAMTS13 assay
- Utilized as a predictive tool for thrombotic thrombocytopenic purpura
- Purity confirmed by HPLC
- Light yellow to yellow solid appearance