Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Vasopressin-d5 TFA (Arginine vasopressin-d5 TFA) | 113-79-1 | 5MG
Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 and is an isotope-labeled compound of Vasopressin. Vasopressin is a cyclic nonapeptide produced in the hypothalamus. It is involved in the hypothalamic-pituitary-adrenal axis, regulating pituitary corticotropin secretion by enhancing the stimulatory effects of corticotropin-releasing factor. Additionally, Vasopressin acts as a neurotransmitter by binding to specific G protein-coupled receptors.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC JBJ-09-063 TFA | 99.6% | 670.67 | 5 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. It effectively reduces EGFR, Akt and ERK1/2 phosphorylation and is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 TFA can be used for researching EGFR-mutant lung cancer.
- Effectively inhibits cell growth and increases apoptosis, even in gefitinib-resistant H3255GR cells with an EGFR T790M mutation.
- Shows efficacy in H1975 cells expressing osimertinib-resistant mutations.
- Exhibits IC50s of 50 nM and 6 nM in Ba/F3 cell when used alone or in combination.
- Has favorable pharmacokinetic properties and good efficacy upon oral dosing.
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | 1037658 | C33H33F3N8O7 | 25 MG
Pyridostatin TFA is a G-quadruplex DNA stabilizing agent with a Kd of 490 nM, targeting both DNA and RNA G4s within cells. This selective small molecule promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage and affects proto-oncogene Src.
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Reduces SRC protein levels and cellular motility in breast cancer cells
- Causes neurite retraction, synaptic loss, and dose-dependent neuronal death in cultured primary neurons
- Induces DNA DSBs in cultured primary neurons
- Downregulates BRCA1 protein at the transcriptional level
- High purity: 99.17%
- Solid, white to off-white appearance
Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 1 ML
NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis. It directly blocks the interaction between CD47 and SIRPα axis.
- Selective inhibitor
- Targets CD47/SIRPα axis
- IC50 of 50 μM
- Blocks CD47 and SIRPα axis interaction
Medchemexpress LLC SIAIS100 TFA | C46H51ClF5N9O7S | 25 MG
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with a DC50 value of 2.7 nM. It is used for research into chronic myeloid leukemia (CML), exhibiting anti-proliferative activity against K562 cells with an IC50 value of 12 nM. This compound degrades BCR-ABL with high ratios at nanomolar concentrations and maintains a durable cellular response after drug removal.
- Potent BCR-ABL PROTAC degrader
- Used for chronic myeloid leukemia (CML) research
- Exhibits anti-proliferative activity against K562 cells
- Induces sustained and robust BCR-ABL degradation
- Degrades G250E/T315I mutation dose-dependently
Medchemexpress LLC Pyridostatin (TFA) | 1472611-44-1 | C33H33F3N8O7 | 5 MG
Pyridostatin (TFA) | 1472611-44-1 | C33H33F3N8O7 | 5 MG
Medchemexpress LLC WAAG-3R TFA | 99.8% | 1644.74 | 1 MG
WAAG-3R TFA is a biologically active peptide. Aggrecanases, which are part of the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases, cleave aggrecan, a main structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a significant aggrecanase in human osteoarthritic cartilage. This FRET peptide was utilized in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay with Ex/Em = 340/420 nm.
- Biologically active peptide.
- Utilized in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay.
- FRET peptide with Ex/Em = 340/420 nm.
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 25 MG
KQFK TFA is a peptide, the trifluoroacetate salt form of KQFK, and serves as an inactive control for KRFK, a peptide derived from TSP-1. This product is for research use only and has not been fully validated for medical applications.
- Molecular formula: C32H46F9N7O12
- Molecular weight: 891.73
- Purity (LCMS): 99.55%
- Appearance: White to off-white solid
- Storage: Powder at -80°C for 2 years or -20°C for 1 year; in solvent at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Medchemexpress LLC MS15 TFA | C66H80F3N11O7S | 1 MG
MS15 TFA is a potent and selective PROTAC (proteolysis-targeting chimera) degrader that targets AKT. It effectively inhibits the activity of all three AKT isoforms (AKT1, AKT2, and AKT3) with varying potencies. This compound is suitable for research applications to study AKT's role in cellular processes.
- It is a potent and selective AKT PROTAC degrader.
- It inhibits AKT1 activity with an IC50 of 798 nM.
- It inhibits AKT2 activity with an IC50 of 90 nM.
- It inhibits AKT3 activity with an IC50 of 544 nM.
- It is bioavailable in mice through intraperitoneal administration.
- It is supplied as a solid with a white to yellow appearance.
- It is soluble in DMSO at concentrations of 100 mg/mL or higher.
Medchemexpress LLC Gln-AMS TFA | 99.9% | 588.47 | 100 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor, specifically inhibiting glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Inhibits glutaminyl-tRNA synthetase (GlnRS)
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- White to off-white solid
- Purity of 99.85%
- Soluble in DMSO at 100 mg/mL
- Store at -20°C under nitrogen
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%
Medchemexpress LLC 3x DYKDDDDK Tag (TFA) | 98.17% | 3116.90 | 5 MG
DYKDDDDK peptide (FLAG) is a useful tool for investigating the function and localization of proteins when antibodies are not available. It is often used in a 3X FLAG format for purifying difficult proteins that accumulate in low abundance.
- Useful tool for investigating protein function and localization
- Often used in 3X FLAG format for purifying difficult proteins
- Suitable for proteins that accumulate in low abundance