Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 25 MG
PBX-7011 TFA is a derivative of camptothecin that exhibits anticancer activity. It functions by inhibiting the expression of cancer-related survival genes, specifically DDX5, Survivin, Mcl-1, and XIAP, in FaDu cells. Additionally, it degrades DDX5 proteins.
- Derivative of camptothecin.
- Inhibits expressions of cancer related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC FStAx-35R TFA | 97.4% | 2885.36 (free base) | 1 MG
fStAx-35R TFA is a hydrocarbon-stapled peptide that inhibits the Wnt/β-catenin signaling pathway by disrupting the β-catenin-TCF interaction. It can be utilized in cancer research.
- Inhibits Wnt/β-catenin signaling pathway
- Disrupts β-catenin-TCF interaction
- Suitable for cancer research
Medchemexpress LLC 5A2-SC8 TFA | 1857341-90-2 | 98.6% | C93H173N5O20S5.xC2HF3O2 | 1 MG
5A2-SC8 TFA is an ionizable amino lipid utilized in lipid nanoparticles (LNPs), demonstrating significant potential for drug delivery with low in vivo toxicity. It facilitates the efficient delivery of small RNAs, such as siRNA and miRNA, specifically into tumor cells. This compound's LNPs can uniquely influence the delivery fate of RNA within the liver, thereby improving therapeutic outcomes in various cancer models.
- High delivery potential.
- Low in vivo toxicity.
- Enables efficient delivery of small RNAs (siRNA and miRNA) into tumor cells.
- Can alter therapeutic outcomes in cancer models by influencing RNA delivery in the liver.
![Medchemexpress LLC Coenzyme A S-[2-[[(5S)-5-(acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl] trifluoroacetic acid | 00-00-0 | 98.5% | C33H54F3N10O21P3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261718.png-250.jpg)
Medchemexpress LLC Coenzyme A S-[2-[[(5S)-5-(acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl] trifluoroacetic acid | 00-00-0 | 98.5% | C33H54F3N10O21P3S | 10MG
Lys-CoA TFA (Lys-coenzyme A) is a selective inhibitor of the p300 histone acetyltransferase used as a biochemical tool to study p300-mediated acetylation and transcriptional regulation. It exhibits nanomolar potency against p300 and marked selectivity over related acetyltransferases, and is supplied as a high-purity solid for laboratory research.
- Selective p300 HAT inhibitor with p300 IC50 50-500 nM
- Greater than 100-fold selectivity over PCAF
- High purity (98.5%) for research applications
- Solid, white to off-white physical form
- Recommended sealed storage at -20°C; in solvent store at -80°C for long-term
eMolecules 76-05-1 | Trifluoroacetic acid | Chem-Impex | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 272384819
Trifluoroacetic acid | Chem-Impex | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 1kg | 272384819
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397365.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 | 10 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue.
- Acts as a GnRH receptor agonist.