Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Sar441255 TFA | 99.93% | 4866.56 (free base) | 5 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys. This product is for research use only.
- Potent unimolecular peptide
- GLP-1/GIP/GCG receptor triagonist
- Displays high potency
- Balanced activation of target receptors
- Shows positive acute glucoregulatory effects
- For research use only
Medchemexpress LLC (RXR)4XB TFA | 96.6% | 5 MG
(RXR)4XB TFA is a cell-penetrating peptide that binds phosphorodiamidate morpholino oligomers (PMOs), forming peptide-conjugated PMOs (PPMOs). It improves the delivery of PMO into bacterial cells.
- Prevents biofilm formation
- Inhibits *Pseudomonas aeruginosa* with an MIC50 of 0.5 to 16 μM
- Reduces bacterial burden in mouse acute pneumonia models
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 10MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, functioning as a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. It induces mitochondrial alterations, reactive oxygen species generation, and intracellular calcium accumulation, leading to calcium-dependent cell death in breast cancer cells. This compound also activates the immune system in breast cancer cells via immunogenic cell death.
- Conjugated peptide acting as a CD47 agonist
- Thrombospondin-1 peptide mimic
- Exhibits antitumor effects
- Induces mitochondrial alterations
- Promotes reactive oxygen species (ROS) generation
- Causes intracellular calcium (Ca+) accumulation
- Leads to calcium-dependent cell death in breast cancer cells
- Activates the immune system through immunogenic cell death
Medchemexpress LLC T7 Tag Peptide TFA | 245445-88-9 | 98.7% | 1098.27 | 5 MG
T7 Tag Peptide is a protein tag composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. This peptide can be fused to the N-terminus or C-terminus of proteins, such as enhanced green fluorescent protein (EGFP), and is utilized in various immunoassays and affinity purification processes.
- Composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10
- Can be fused to the N-terminus or C-terminus of proteins
- Useful in various immunoassays
- Aids in affinity purification processes
Medchemexpress LLC L2P4 (TFA) | 98.3% | 1961.83 (free base) | 25 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe that inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. It exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based fluorescent probe
- Targets EBNA1
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Relevant to peptide-drug conjugates (PDCs) and EBV research
- Related to antibody-drug conjugate/ADC and anti-infection pathways
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 | 5 MG
FLAG peptide TFA is the trifluoroacetic acid salt form of FLAG peptide, often denoted as HY-P0223. It functions as a versatile fusion tag specifically designed for the purification of recombinant proteins. This peptide plays a crucial role in maintaining the natural, functional folding of the proteins it is fused with, ensuring their biological activity. It can be efficiently removed by enterokinase and is capable of being eluted under non-denaturing conditions, which is beneficial for preserving protein integrity.
- Multifunctional fusion tag
- Used for purification of recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC FRETS-VWF73 (TFA) | 96.8% | 9340.61 | 500 UG
FRETS-VWF73 (TFA) is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay. This peptide is utilized as a predictive tool for thrombotic thrombocytopenic purpura, offering a valuable resource for research and diagnostic applications.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Used as a predictive tool for thrombotic thrombocytopenic purpura
- Excitation at 340 nm; emission at 450 nm
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 25 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. It inhibits the proliferation of NSCLC cells and can be used for anticancer research. MS9427 TFA has antiproliferative activity against HCC-827 cells, potently inducing EGFRDel19 degradation and inhibiting EGFR phosphorylation.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Functions through ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways
- Inhibits proliferation of NSCLC cells
- Supports anticancer research
- Displays antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
- Inhibits EGFR phosphorylation
Medchemexpress LLC Dendrotoxin K TFA | 99.5% | 6559.66 (free base) | 1 MG
Dendrotoxin K TFA is a Kv1.1 channel blocker. It determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform.
- Kv1.1 channel blocker
- Determines glutamate release in CA3 neurons
- Controls presynaptic spike waveform
Medchemexpress LLC Hth-01-091 Tfa | 2000209-42-5 | 98.64% | 499.43 | 1 MG
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. It also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. This compound can be used for breast cancer research.
- Potent and selective MELK inhibitor.
- Inhibits multiple kinases including PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2.
- Suitable for breast cancer research.
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC DPC-AJ1951 TFA | 99.4% | 1666.99 (free base) | 5 MG
This 14 amino acid peptide acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption.
- Potent agonist of parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo bone resorption assays
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with human PPR
Medchemexpress LLC Vasopressin-d5 (TFA) | 113-79-1 | 98.0% | 1 MG
Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5. It is an isotope-labeled compound of Vasopressin, a cyclic nonapeptide synthesized centrally in the hypothalamus. It participates in the hypothalamic-pituitary-adrenal axis, regulating pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin can also act as a neurotransmitter by binding to specific G protein-coupled receptors.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC MIP-1095 trifluoroacetate | 00-00-0 | MFCD09802015 | 99.8% | 678.35 g/mol | C21H26F3IN4O10 | 5 MG
MIP-1095 trifluoroacetate is a small-molecule inhibitor of prostate-specific membrane antigen used for research and imaging probe development. The compound is supplied as a high-purity trifluoroacetate salt, suitable for radiolabeling and preclinical assays.
- Potent inhibitor of prostate-specific membrane antigen (PSMA).
- Provided as trifluoroacetate (TFA) salt for stability.
- High purity suitable for research applications.
- Compatible with radiolabeling for imaging probe development.
- Soluble in DMSO for assay preparation.
- Available in small-mass quantities for preclinical studies.