Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC CL2A (TFA) | 2616704-22-2 | 99.5% | 1176.24 | C50H79N9O16 | 5 MG
CL2A (TFA) is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker for use in antibody-drug conjugate construction. The TFA salt form improves handling and stability and is designed to release payloads under acidic conditions to produce a bystander effect.
- Cleavable linker enabling payload release under acidic conditions.
- PEG8 spacer and triazole moiety for increased solubility and stability.
- Designed for conjugation to antibody cysteine residues via disulfide linkage.
- Available in small research-scale packages for use in ADC development.
- Stable as a powder when stored sealed at 4°C; shipped at room temperature.
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC MC-VC-PAB-NH2 TFA | 1616727-21-9 | 99.9% | 772.77 | 1 MG
MC-VC-PAB-NH2 TFA is a cleavable antibody-drug conjugate (ADC) linker, utilized in the synthesis of ADCs. ADCs are composed of an antibody to which an ADC cytotoxin is attached via an ADC linker.
- Cleavable antibody-drug conjugate linker
- Utilized in the synthesis of ADCs
- High purity of 99.9%
- Appears as a white to off-white solid
- Protease cleavable
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES LC-MS TRIFLUOROACETIC ACID50ML
NC2952351 LC-MS TRIFLUOROACETIC ACID50ML
Medchemexpress LLC JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
Medchemexpress LLC Glycyl-exatecan (TFA) | 1883333-57-0 | 96.9% | 100 MG
Glycyl-Exatecan TFA is a derivative of Exatecan, known for its significant antitumor activity. This compound acts as an anticancer agent and is suitable for research applications, particularly in studies involving solid tumors.
- Acts as an anticancer agent
- Exhibits significant antitumor activity
- Suitable for solid tumors research
- Derivative of Exatecan
Medchemexpress LLC Mtvkpabc-p5 TFA | 98.8% | 1190.22 | C54H74F3N11O16 | 25 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt of a synthetic Toll-like receptor 7 (TLR7) agonist. It functions as an immune stimulant used in research applications, including the synthesis of immune-stimulating antibody conjugates (ISACs).
- Acts as a TLR7 agonist and immune stimulant.
- Suitable for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a solid TFA salt.
- High purity, 98.8%.
- Molecular weight 1190.22, formula C54H74F3N11O16.
- Available as 25 MG quantity.
eMolecules Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | >98.0% | 1 ML
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with anti-cancer activity, designed for research applications.
- Potent and orally active dual JAK2/FLT3 inhibitor.
- Exhibits anti-cancer activity.
- Down-regulates p-FLT3 in a dose-dependent manner.
- Induces apoptosis and cell cycle arrest in MV4-11 cells.
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 50 MG
Glycyl-Exatecan TFA is a derivative of Exatecan and functions as an anticancer agent. It exhibits significant antitumor activity and can be utilized for research concerning cancers like solid tumors.
- Derivative of Exatecan
- Functions as an anticancer agent
- Exhibits significant antitumor activity
- Utilized in research concerning cancers like solid tumors