Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
eMolecules 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | 76045-93-7 | MFCD28396350 | 1g
Oakwood Chemical | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | 1g | 537706582 | 098500 | | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2
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Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 ML
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. It inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM and does not influence RAD51 binding to ssDNA.
- Potent and selective RAD51-mediated D-loop formation inhibitor
- IC50 of 11.1 μM for D-loop formation
- Inhibits homologous recombination (HR) activity in human cells
- Does not influence RAD51 binding to ssDNA
- Stabilizes nucleoprotein filaments in a nonfunctional state
- Shielded from pathways promoting single-strand annealing
Medchemexpress LLC Difopein TFA | 96.30% | 6387.17 (free acid) | 5 MG
Difopein TFA is a specific and competitive inhibitor of the 14-3-3 protein, a highly conserved eukaryotic regulatory molecule. It functions by blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. This compound is not cell permeable and induces apoptosis, enhancing the ability of Cisplatin to kill cells.
- Specific and competitive inhibitor of 14-3-3 protein
- Blocks 14-3-3 from binding to target proteins
- Inhibits 14-3-3/ligand interactions
- Induces apoptosis
- Enhances cisplatin's ability to kill cells
- Target: 14-3-3 protein
- Soluble in DMSO at ≥ 100 mg/mL
- In vivo soluble at ≥ 2.5 mg/mL with specific protocol
- Recommended storage for powder: -80°C for 2 years; -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Homoglutathione trifluoroacetate | 435.37 | C13H20F3N3O8S | 25mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC Saralasin TFA | 34273-10-4 | 99.18% | 1026.07 | 25 MG
Saralasin TFA, an octapeptide analog of angiotensin II, functions as a competitive angiotensin II receptor antagonist and exhibits partial agonist activity. It is utilized in the research of renovascular hypertension and renin-dependent (angiotensinogenic) hypertension.
- Competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM.
- Exhibits partial agonist activity.
- Inhibits cell growth in 3T3 and SV3T3 cells.
- Restores potassium currents in myocytes.
- Inhibits binding of FITC-Ang II to rat liver membrane preparation.
- Reduces ovulation rate and prostaglandin levels in vitro.
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis in rats.
- Increases serum renin activity in normal, conscious rats.
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 1 MG
L2P4 TFA is a peptide-based, EBNA1 targeting fluorescent probe. It works by inhibiting EBNA1 homodimer formation, which selectively inhibits EBV+ tumor growth. It shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based, EBNA1 targeting fluorescent probe
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Shows cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM
- Molecular weight: 1961.83 (free base)
- Appearance: Solid
- Color: Purple to purplish red
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 5 MG
Tpp-CAQK TAF can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK TFA, with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Binds to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in spinal cord injury
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 5 MG
L2P4 TFA is a peptide-based and EBNA1 targeting fluorescent probe. It inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. L2P4 TFA exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based probe
- EBNA1 targeting
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells
- Suitable for cancer targeted therapy and immunotherapy research
- Used in peptide-drug conjugates research
Medchemexpress LLC GRGDSP TFA | 98.0% | 701.61 | 25 MG
GRGDSP (TFA) is an integrin inhibitor. This synthetic linear RGD peptide can inhibit the adherence of tumor cells to endothelial cells of blood vessels, thereby limiting metastasis. It is also utilized to modify the surface of cardiovascular implants, such as vascular grafts, to promote endothelialization, and is widely employed in integrin research as a soluble integrin-blocking RGD-based peptide.
- Inhibits adherence of tumor cells to endothelial cells of blood vessels
- Limits metastasis
- Promotes endothelialization for cardiovascular implants
- Used in integrin research
- Functions as a soluble integrin-blocking RGD-based peptide
Medchemexpress LLC FLAG peptide TFA | 99.6% | 1012.97 (free base) | 25 MG
FLAG peptide TFA is the TFA salt form of FLAG peptide. It is a multifunctional fusion tag used for the purification of recombinant proteins. It maintains the natural folding of its fusing proteins and can be removed by enterokinase, and eluted under non-denaturing conditions.
- Used as a multifunctional fusion tag
- Purifies recombinant proteins
- Maintains natural folding of fusing proteins
- Can be removed by enterokinase
- Eluted under non-denaturing conditions
Medchemexpress LLC MIP-1095 (TFA) | 99.8% | 678.35 | 25 MG
MIP-1095 TFA (RPS-001 TFA) is a potent inhibitor of PSMA, demonstrating good biodistribution and efficient targeting of tumor lesions. It is utilized as an imaging probe to identify and monitor tumor progression, particularly when isotopically labeled with 131I. This labeling results in 131I-MIP-1095 showing higher renal uptake in mice.
- Potent inhibitor of PSMA
- Good biodistribution
- Efficient targeting of tumor lesions
- Can be isotopically labeled as an imaging probe
- Higher renal uptake in mice when labeled with 131I
- Used as an imaging probe to indicate tumor progression