Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TL033 | 2356230-22-1 | 1630.83 | 25 MG
TL033 is a chemical substance identified for laboratory use, including the manufacture of other substances. It is supplied as a solid and is intended for research purposes only by experienced personnel.
- Identified for laboratory chemical manufacturing
- Supplied as a solid
- Recommended storage at -20°C, protected from light
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC RVD-Hpα TFA | 1431329-51-9 | 99.32% | 1538.67 | 1 MG
RVD-Hpα TFA is the N-terminally extended form of human hemopressin. It functions as a selective CB1 receptor agonist, increasing intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. It also acts as a high-affinity CB2 positive allosteric modulator.
- Acts as a selective CB1 receptor agonist
- Increases intracellular Ca2+ levels in CB1 receptor expressing cells
- Functions as a high-affinity CB2 positive allosteric modulator (Ki=50 nM)
Medchemexpress LLC MIP-1095 (TFA) | 99.8% | 678.35 | 25 MG
MIP-1095 TFA (RPS-001 TFA) is a potent inhibitor of PSMA, demonstrating good biodistribution and efficient targeting of tumor lesions. It is utilized as an imaging probe to identify and monitor tumor progression, particularly when isotopically labeled with 131I. This labeling results in 131I-MIP-1095 showing higher renal uptake in mice.
- Potent inhibitor of PSMA
- Good biodistribution
- Efficient targeting of tumor lesions
- Can be isotopically labeled as an imaging probe
- Higher renal uptake in mice when labeled with 131I
- Used as an imaging probe to indicate tumor progression
Medchemexpress LLC APL180 TFA (L-4F TFA) | 98.8% | 2310.60 (free base) | 25 MG
APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL). APL180 can be used in the study of cardiovascular diseases.
- Apolipoprotein AI mimetic peptide
- Enhances the anti-inflammatory activity of high-density lipoprotein (HDL)
- Can be used in the study of cardiovascular diseases
Apexbio Technology LLC SUPER-TDU-TFA-1MG
Super-TDU TFA (CAS No 1599441-71-0) is an advanced compound frequently used in the biomedical research field particularly known for its role in investigating intracellular signaling pathways and targeting specific cellular proteins Originating from cutting-edge chemical synthesis it primarily operates by modulating specific enzymatic pathways making it a crucial tool for studying cellular mechanisms Known for its high potency this compound exhibits in vitro activity ranging from nanomolar to low micromolar concentrations facilitating precise experimental data It is widely employed in various research applications including cell models and animal studies and is integral to drug screening processes for identifying potential therapeutic candidates Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC FOXY-5-TFA-1MG
Foxy-5 TFA (CAS No 881188-51-8) is a synthetic peptide that plays a pivotal role in biomedical research particularly in cancer studies Originating from cancer research labs its mechanism of action involves mimicking the Wnt-5a protein which influences key signaling pathways such as the Wnt/ -catenin pathway This regulation is crucial in modulating cancer cell movement and metastasis Foxy-5 TFA demonstrates significant in vitro activity typically ranging from nanomolar to low micromolar concentrations It is commonly used in various cell models including breast and prostate cancer lines and has applications in animal studies for assessing metastasis inhibition Additionally it serves as an essential tool in drug screening to evaluate compounds targeting cancer metastasis pathways Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC Urotensin-II-114-124-human-TFA
Urotensin II (114-124 human) TFA (CAS No 251293-28-4) is a peptide fragment primarily utilized in cardiovascular and neurological research It originates from human urotensin II a potent vasoactive peptide involved in various physiological processes primarily acting through the G protein-coupled urotensin II receptor (UT) This interaction influences cellular pathways related to vasoconstriction and vascular smooth muscle proliferation In vitro this fragment functions in the nanomolar to low micromolar range demonstrating significant potency in cellular assays Typically employed in cell models and animal studies it aids in exploring cardiovascular dysfunction evaluating potential therapeutic agents and drug screening protocols Experimental concentrations typically depend on the specific research design ensuring flexibility for diverse investigative focuses
Apexbio Technology LLC Urotensin-II-114-124-human-TFA
Urotensin II (114-124 human) TFA (CAS No 251293-28-4) is a peptide fragment primarily utilized in cardiovascular and neurological research It originates from human urotensin II a potent vasoactive peptide involved in various physiological processes primarily acting through the G protein-coupled urotensin II receptor (UT) This interaction influences cellular pathways related to vasoconstriction and vascular smooth muscle proliferation In vitro this fragment functions in the nanomolar to low micromolar range demonstrating significant potency in cellular assays Typically employed in cell models and animal studies it aids in exploring cardiovascular dysfunction evaluating potential therapeutic agents and drug screening protocols Experimental concentrations typically depend on the specific research design ensuring flexibility for diverse investigative focuses
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 500 UG
Dendrotoxin-I TFA is a potent K+ channel blocker effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6, with IC50s ranging from 0.13-50 nM. This neurotoxin holds potential in cancer research, as demonstrated by its significant tumor growth inhibition effect when combined with hyperthermia in nude mice with MCF-7 cells.
- Potent K+ channel blocker
- Effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6
- Exhibits neurotoxic properties
- Potential for use in cancer research
- Demonstrated tumor growth inhibition in in vivo studies
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 500 UG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. As a member of the insulinotropic hormone peptide family, it stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest that GIP plays a role in lipid homeostasis and may be involved in the pathogenesis of obesity. It is for research use only.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Involved in lipid homeostasis and obesity pathogenesis (potential)
- For research use only
Medchemexpress LLC LL-37, human TFA | 154947-66-7 | 100.0% | 4493.26 | 5 MG
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide. It demonstrates a broad spectrum of antimicrobial activity.
- Exhibits broad-spectrum antimicrobial activity.
- May help protect the cornea from infection.
- Modulates wound healing.
Medchemexpress LLC Astressin 2B TFA | 99.54% | 4041.69 | 500 UG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. It also reverses the protective effects of Urocortin 1 and attenuates stress-induced anxiety-related behaviors. This product is a valuable tool for investigating the intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist (IC50=0.57 nM).
- Blood-brain barrier-impermeable.
- Exacerbates indomethacin-induced hemorrhagic intestinal injury.
- Reverses protective effects of urocortin 1.
- Attenuates stress-induced anxiety-related behaviors.
- Valuable tool for studying CRFR2 intestinal protective mechanisms.
Medchemexpress LLC HDAC11-IN-1 TFA | 99.3% | 995.15 | 1 MG
HDAC11-IN-1 TFA is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. It exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2. The product is for research purposes only and is not sold to patients.
- Selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM.
- Exhibits good cell permeability.
- Can inhibit the expression of YAP1 and SOX2.
- For research purposes only.