Alkyl fluorides
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 100 MG
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. It is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
- Orally bioavailable.
- Highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE).
- IC50 of 20 nM for HNE.
- Nominated as a chemical probe via the Structural Genomics Consortium (SGC).
- Ki value for MNE is 700 nM.
- 4th generation inhibitor of HNE.
- More than 2,000-fold selectivity in a panel of 21 serine proteases.
- Reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating anti-inflammatory and anti-remodeling mode of action.
- Shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
Medchemexpress LLC BAY-678 | 675103-36-3 | 99.6% | 400.35 | 1 ML
BAY-678 is an orally bioavailable, highly potent, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. It has been nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). It demonstrates significant efficacy in preclinical models of ALI and lung emphysema, showing anti-inflammatory and anti-remodeling actions. Additionally, it has shown beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
- Orally bioavailable and cell-permeable inhibitor of human neutrophil elastase
- Exhibits more than 2,000-fold selectivity in a panel of 21 serine proteases
- Shows significant efficacy in preclinical models of ALI and lung emphysema
- Demonstrates anti-inflammatory and anti-remodeling modes of action
- Beneficial pulmonary hemodynamic and vascular effects in models of PAH
Medchemexpress LLC Perfluorohexanoic acid (Undecafluorocaproic acid) | 307-24-4 | 99.90% | 314.05 | 500 MG
Perfluorohexanoic acid, also known as Undecafluorocaproic acid, is a biological molecule for research use only.
- High purity: 99.90%
- Molecular weight: 314.05
- Appearance: solid below 12°C, liquid above 14°C
- Color: colorless to off-white
- Formula: C6HF11O2
- Recommended storage: room temperature for 3 years; in solvent, -80°C for 2 years or -20°C for 1 year.
Matrix Scientific PERFLUOROHEPTANOIC ACID-25G
Perfluoroheptanoic acid, 98%; 25g,C7HF13O2, MFCD00039604, mw 364.06, [375-85-9]
Cayman Chemical Heptafluorobutyric Acid, Purity: ≥80%, CAS: 375-22-4, 50 g
A perfluoroalkyl substance; chronic topical administration on the ear increases liver and kidney weight in mice at 25 µl of a 3.75-15% v/v on the ear; induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy at 7.5% v/v; increases serum cholesterol and ALP levels at 15% v/v; decreases serum urea nitrogen levels; has been found in marine life and as a contaminant in surface water
Cayman Chemical Heptafluorobutyric Acid, Purity: ≥80%, CAS: 375-22-4, 10 g
A perfluoroalkyl substance; chronic topical administration on the ear increases liver and kidney weight in mice at 25 µl of a 3.75-15% v/v on the ear; induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy at 7.5% v/v; increases serum cholesterol and ALP levels at 15% v/v; decreases serum urea nitrogen levels; has been found in marine life and as a contaminant in surface water
SPEX CERTIPREP LLC 3P Perfluorohexanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
Perfluorohexanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
SPEX CERTIPREP LLC 3P Perfluoroundecanoic acid, n-isomer (major); 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
Perfluoroundecanoic acid, n-isomer (major); 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
SPEX CERTIPREP LLC 3P n-Perfluoropentanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
n-Perfluoropentanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
SPEX CERTIPREP LLC 3P n-Perfluorooctanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
n-Perfluorooctanoic acid; 50 µg/mL in MeOH with 4 mole eq. NaOH; 1 mL
Cayman Chemical 2H,2H,3H,3H-Perfluorooctanoic Acid, Purity: ≥90%, CAS: 914637-49-3, 100 mg
A polyfluoroalkyl substance; has been found as a contaminant in wastewater
Medchemexpress LLC Perfluorododecanoic acid | 307-55-1 | MFCD00198081 | 95.0% | 614.10 g/mol | C12HF23O2 | 100 MG
Perfluorododecanoic acid (PFDoA) is a perfluoroalkyl carboxylic acid used as a research reagent in environmental, toxicological, and analytical studies of per- and polyfluoroalkyl substances (PFAS). It is supplied as a solid for laboratory use and is not intended for human or clinical applications.
- 95.0% purity.
- Molecular formula C12HF23O2.
- Molecular weight 614.10 g/mol.
- CAS number 307-55-1.
- Supplied in 100 mg quantity.
- For research use only; not for human use.
- Suitable for PFAS environmental and toxicology studies.
AdipoGen Ethyl pentafluoropropionate
Chemical. CAS 426-65-3. Formula C5H5F5O2. MW 192.08. Building block for synthesis. Perfluoroalkyl carboxylate esters undergo Wittig reactions with phosphorus leading to 1-perfluoroalkyl enol ethers, which are useful precursors of various fluorinated derivatives.