Alkyl fluorides
Medchemexpress LLC Perfluorododecanoic acid | 307-55-1 | MFCD00198081 | 95.0% | 614.10 g/mol | C12HF23O2 | 50 MG
Perfluorododecanoic acid is a perfluoroalkyl carboxylic acid used as a research reagent for studies of environmental distribution and biological effects of PFAS compounds. It is supplied as a solid for laboratory and analytical applications; consult the safety data sheet for handling and storage instructions.
- Perfluorinated C12 carboxylic acid for PFAS research.
- Purity 95.0% suitable for analytical methods.
- Molecular weight 614.10 g/mol.
- Chemical formula C12HF23O2.
- Supplied as 50 MG solid quantity.
- For research use only; not for human or clinical use.
TARGETMOL CHEMICALS INC Perfluorooctanoic acid 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical. Purity 100%
TARGETMOL CHEMICALS INC BAY-678 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY-678 is a human neutrophil elastase (HNE; IC50 20 nM) inhibitor with oral bioactivity potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC). purity: 98%
TARGETMOL CHEMICALS INC X-376 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration X-396 binds to and inhibits ALK kinase ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. purity: 98%
Medchemexpress LLC Ensartinib | 1365267-27-1 | 98.10% | 547.41 | 10 MM * 1 ML
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM), exhibiting potent anti-tumor activity. This compound shows substantial bioavailability and moderate half-lives in vivo. Intended for research use only, animal studies indicate it is well-tolerated at effective doses without significant toxicity up to 50 mg/kg in SD rats.
- Potent ALK inhibitor (IC50: 0.61 nM)
- Inhibits MET (IC50: 0.69 nM)
- Potent in H3122, H2228, and SUDHL-1 cancer cells
- Soluble in DMSO (100 mg/mL)
- Well-tolerated in vivo with anti-tumor activity
- Stock solution storage: -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC X-376 | 1365267-27-1 | 98.10% | 547.41 | 25 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM) and exhibits potent anti-tumor activity.
- Effective in inhibiting the growth of various cancer cell lines, including H3122 lung cancer cells (IC50: 77 nM), H2228 lung cancer cells (IC50: 57 nM), and SUDHL-1 lymphoma cells (IC50: 32 nM).
- Also inhibits SY5Y neuroblastoma cells, MKN-45 gastric carcinoma cells, HepG2 cells, and PC-9 lung cancer cell lines.
- Demonstrates substantial bioavailability and moderate half-lives in vivo.
- Significantly delays tumor growth in H3122 xenografts at a dose of 50 mg/kg bid, appearing well-tolerated without affecting mouse weight or causing compound-related toxicity.