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Filtered Search Results
eMolecules 1226769-58-9 | 6-Methoxypyridin-2-ylmagnesium bromide, 0.25 M in THF | Synthonix212.329 | C6H6BrMgNO | 0.000 | [Br-].COc1cccc([Mg+])n1 | 50ml | 702445946
6-Methoxypyridin-2-ylmagnesium bromide, 0.25 M in THF | Synthonix | 1226769-58-9212.329 | C6H6BrMgNO | 0.000 | [Br-].COc1cccc([Mg+])n1 | 50ml | 702445946
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Apexbio Technology LLC BI-847325 1207293-36-4 25mg
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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eMolecules 1390658-33-9 | 2,3-Difluorobenzylzinc bromide, 0.50 M in THF | Synthonix272.400 | C7H5BrF2Zn | 0.000 | [Br-].Fc1cccc(C[Zn+])c1F | 25ml | 627353594
2,3-Difluorobenzylzinc bromide, 0.50 M in THF | Synthonix | 1390658-33-9272.400 | C7H5BrF2Zn | 0.000 | [Br-].Fc1cccc(C[Zn+])c1F | 25ml | 627353594
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AdipoGen Naphthol AS-MX phosphate
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Chemical. CAS 1596-56-1. Formula C19H18NO5P. MW BD9837. Naphthol AS-MX Phosphate is a fluorogenic substrate for alkaline phosphatases. Naphthol AS-MX Phosphate is converted to naphthol AS-MX displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications.
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Medchemexpress LLC (±)-BI-D | 1416258-16-6 | 98.1% | 10 MG
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(±)-BI-D is an allosteric HIV integrase inhibitor used in research to study integrase function and antiviral activity. It binds the LEDGF/p75 binding site on integrase and has demonstrated inhibition of HIV-Luc infection in cellular assays.
- Potent ALLINI mechanism of action.
- Binds LEDGF/p75 integrase site to disrupt viral integration.
- Demonstrated cellular activity (reported IC50s: 0.16 μM and 2.9 μM).
- Available as solid and as a 10 mM solution in DMSO for assay setup flexibility.
- High purity and defined molecular weight and formula for reproducible studies.
- Intended for biochemical and cellular research use only; not for human use.
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eMolecules 111298-88-5 | [5-[tert-butyl(dimethyl)silyl]oxypentyl]magnesium bromide, 0.50 M in THF | Synthonix305.614 | C11H25BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)OCCCCC[Mg+] | 25ml | 844919952
[5-[tert-butyl(dimethyl)silyl]oxypentyl]magnesium bromide, 0.50 M in THF | Synthonix | 111298-88-5305.614 | C11H25BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)OCCCCC[Mg+] | 25ml | 844919952
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eMolecules 1025745-87-2 | 2-Fluoro-5-methyl-3-(tributylstannyl)pyridine | Synthonix - Stock | MFCD09025799 | 400.169 | C18H32FNSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cc(C)cnc1F | 500mg | 525917318
2-Fluoro-5-methyl-3-(tributylstannyl)pyridine | Synthonix - Stock | 1025745-87-2 | MFCD09025799 | 400.169 | C18H32FNSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cc(C)cnc1F | 500mg | 525917318
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eMolecules 5292-43-3 | tert-Butylbromoacetate | Oakwood Chemical | MFCD00000188 | 195.056 | C6H11BrO2 | 99.000 | CC(C)(C)OC(=O)CBr | 5g | 537691741
tert-Butylbromoacetate | Oakwood Chemical | 5292-43-3 | MFCD00000188 | 195.056 | C6H11BrO2 | 99.000 | CC(C)(C)OC(=O)CBr | 5g | 537691741
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Medchemexpress LLC Labetalol (hydrochloride) | 32780-64-6 | 99.9% | 25 MG
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Labetalol hydrochloride is an orally available, selective α1-adrenergic receptor and non-selective β-adrenergic receptor competitive antagonist. It is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. It can be used in the study of cardiovascular diseases, such as hypertension during pregnancy.
- Orally available
- Selective α1-adrenergic receptor and non-selective β-adrenergic receptor competitive antagonist
- Antihypertensive molecule
- Partially crosses the blood-brain barrier
- Has little effect on cardiac output
- Used in the study of cardiovascular diseases, such as hypertension during pregnancy
- Exhibits greater affinity for β-adrenergic sites
- Blocks β-adrenergic responses at low doses
- Blocks α-adrenergic responses at high doses
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Alkali Scientific Naphthol AS MX phosphate, 5 Grams
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Naphthol AS MX Phosphate is an enzyme substrate used in laboratory applications to detect and quantify phosphatase activity. It is commonly used in enzyme assays where naphthol AS MX phosphate undergoes hydrolysis by phosphatases, resulting in a colored product. This product is widely employed in immunohistochemistry, enzyme-linked immunosorbent assays (ELISA), and various other biochemical studies. The 5g quantity is ideal for small-scale experiments, providing enough material for multiple assays. It is used to investigate enzyme kinetics, study phosphatase inhibitors, and explore cellular signaling mechanisms. This reagent is essential in laboratories studying enzyme function and related biochemical pathways.
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Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 100 MG
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BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows favorable anti-tumor activity in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- Inhibits GDP-KRAS::SOS1 protein-protein interaction with an IC50 of 7.0 nM
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Shows anti-tumor activity in non-small cell lung cancer xenograft models
- Induces programmed cell death in xenograft models
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eMolecules 1032315-16-4 | 7-Trimethylstannylisoquinoline | Synthonix - Stock | MFCD22199151 | 291.969 | C12H15NSn | 97.000 | C[Sn](C)(C)c1ccc2ccncc2c1 | 500mg | 525924352
7-Trimethylstannylisoquinoline | Synthonix - Stock | 1032315-16-4 | MFCD22199151 | 291.969 | C12H15NSn | 97.000 | C[Sn](C)(C)c1ccc2ccncc2c1 | 500mg | 525924352
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eMolecules 194865-89-9 | 4-(Tributylstannyl)pyridazine | Synthonix - Stock | MFCD07787369 | 369.140 | C16H30N2Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)c1ccnnc1 | 5g | 525923758
4-(Tributylstannyl)pyridazine | Synthonix - Stock | 194865-89-9 | MFCD07787369 | 369.140 | C16H30N2Sn | 95.000 | CCCC[Sn](CCCC)(CCCC)c1ccnnc1 | 5g | 525923758
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AdipoGen Naphthol AS-TR phosphate 2Na
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Chemical. CAS 4264-93-1. Formula C18H13CINNa2O5P. MW BD9837. Naphthol AS-TR Phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-TR Phosphate is converted to naphthol AS-TR displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications. Naphthol AS-TR Phosphate is a cyclic-AMP response element-binding protein CREB-CREB binding protein CBP transcription factor complex inhibitor and a potential therapeutic agent for lung cancer.
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eMolecules 113826-06-5 | (2R)-(-)-Glycidyl tosylate | Ambeed | MFCD00010834 | 228.260 | C10H12O4S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OC[C@H]1CO1 | 1g | 552609531
(2R)-(-)-Glycidyl tosylate | Ambeed | 113826-06-5 | MFCD00010834 | 228.260 | C10H12O4S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OC[C@H]1CO1 | 1g | 552609531
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