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Filtered Search Results
eMolecules 75-09-2 | Methylene Chloride | Oakwood Chemical | MFCD00000881 | 84.930 | CH2Cl2 | 99.000 | ClCCl | 4l | 634025195
Methylene Chloride | Oakwood Chemical | 75-09-2 | MFCD00000881 | 84.930 | CH2Cl2 | 99.000 | ClCCl | 4l | 634025195
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eMolecules 288309-53-5 | 3-Cyanophenylzinc iodide, 0.50 M in THF | Synthonix294.400 | C7H4INZn | 0.000 | [I-].[Zn+]c1cccc(c1)C#N | 25ml | 627353559
3-Cyanophenylzinc iodide, 0.50 M in THF | Synthonix | 288309-53-5294.400 | C7H4INZn | 0.000 | [I-].[Zn+]c1cccc(c1)C#N | 25ml | 627353559
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eMolecules 312693-44-0 | 4-Biphenylzinc bromide, 0.50 M in THF | Synthonix | MFCD02093780 | 298.490 | C12H9BrZn | 0.000 | [Br-].[Zn+]c1ccc(cc1)-c1ccccc1 | 100ml | 532652623
4-Biphenylzinc bromide, 0.50 M in THF | Synthonix | 312693-44-0 | MFCD02093780 | 298.490 | C12H9BrZn | 0.000 | [Br-].[Zn+]c1ccc(cc1)-c1ccccc1 | 100ml | 532652623
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eMolecules 402-51-7 | (4-(Trifluoromethyl)phenyl)magnesium bromide, 0.25 M in THF | Synthonix - Stock | MFCD00672011 | 249.313 | C7H4BrF3Mg | 97.000 | [Br-].FC(F)(F)c1ccc([Mg+])cc1 | 50ml | 348890464
(4-(Trifluoromethyl)phenyl)magnesium bromide, 0.25 M in THF | Synthonix - Stock | 402-51-7 | MFCD00672011 | 249.313 | C7H4BrF3Mg | 97.000 | [Br-].FC(F)(F)c1ccc([Mg+])cc1 | 50ml | 348890464
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eMolecules 672325-70-1 | 3-Bromo-2-thienylzinc bromide, 0.50 M in THF | Synthonix | MFCD02260168 | 307.310 | C4H2Br2SZn | 0.000 | [Br-].[Zn+]c1sccc1Br | 100ml | 532652617
3-Bromo-2-thienylzinc bromide, 0.50 M in THF | Synthonix | 672325-70-1 | MFCD02260168 | 307.310 | C4H2Br2SZn | 0.000 | [Br-].[Zn+]c1sccc1Br | 100ml | 532652617
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Medchemexpress LLC Epirubicin hydrochloride | 56390-09-1 | >99.2% | 579.98 | 100 MG
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Epirubicin hydrochloride is a semisynthetic L-arabino derivative of doxorubicin, functioning as an antineoplastic agent by inhibiting Topoisomerase and DNA/RNA synthesis. It also acts as a Forkhead box protein p3 (Foxp3) inhibitor, suppressing regulatory T cell activity. Its antitumor effects involve forming a complex with DNA, causing damage and interfering with essential synthesis processes.
- Acts as an antineoplastic agent.
- Inhibits Topoisomerase, DNA, and RNA synthesis.
- Functions as a Forkhead box protein p3 (Foxp3) inhibitor.
- Suppresses regulatory T cell activity.
- Causes DNA damage by complexing with DNA.
- Cytotoxic to various cancer cells, including Hepatoma G2 cells (IC50 1.6 μg/mL).
- Induces apoptosis and alters antioxidant enzyme activity in Hep G2 cells.
- Clinically active against a wide range of tumor types.
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eMolecules 984-43-0 | 1,2-Bis(diphenylphosphino)ethane monooxide | Combi-Blocks, Inc. | MFCD00345406 | 414.425 | C26H24OP2 | 96.000 | O=P(CCP(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1 | 1g | 642140582
1,2-Bis(diphenylphosphino)ethane monooxide | Combi-Blocks, Inc. | 984-43-0 | MFCD00345406 | 414.425 | C26H24OP2 | 96.000 | O=P(CCP(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1 | 1g | 642140582
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Medchemexpress LLC Siramesine hydrochloride | 224177-60-0 | >99.69% | C30H32ClFN2O | 25 MG
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Siramesine hydrochloride is a potent sigma-2 receptor agonist, displaying subnanomolar affinity with an IC50 of 0.12 nM. It demonstrates high selectivity for sigma-2 receptors over sigma-1 receptors, with a 140-fold difference in IC50 values (17 nM for sigma-1). This compound induces cell death by destabilizing mitochondria and has shown anti-cancer activity.
- Potent sigma-2 receptor agonist
- High selectivity for sigma-2 over sigma-1 receptors
- Triggers cell death through mitochondrial destabilization
- Exhibits anti-cancer activity
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Apexbio Technology LLC Linagliptin (BI-1356) 668270-12-0 100mg
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Linagliptin (BI-1356 CAS 668270-12-0) is a potent competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) demonstrating IC50 values of 0 4 1 1 nM in multiple in vitro assays using DPP-4 extracted from Caco-2 cells DPP-4 is a membrane-bound and soluble protease involved in the degradation of incretin hormones such as GLP-1 which enhance pancreatic -cell glucose sensitivity and insulin secretion Linagliptin displays marked selectivity for DPP-4 over related peptidases and serine proteases In vivo linagliptin dose-dependently inhibits plasma DPP-4 activity and sustains glycemic control with prolonged effects observed at pharmacologically relevant doses This compound is widely utilized in studies of glucose metabolism and -cell function
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AdipoGen 5-Aminolevulinic acid HCl
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Chemical. CAS 5451-09-2. Formula C5H9NO3 . HCl. MW 131.13 . 36.46. 5-Aminolevulinic acid 5-ALA is a non-proteinogenic five carbon amino acid, which is the precursor for the biosynthesis of tetrapyrrole compounds, such as heme, chlorophyll and vitamin B12 and has broad applications in the medical and agricultural fields. The conversion of 5-ALA to protoporphyrins within tissues produces a photosensitive target that produces reactive oxygen species upon exposure to light. In this way, it is used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases. Oral administration of 5-ALA leads to the preferential accumulation of the fluorescent molecule protoporphyrin IX within certain types of cancer cells. This allows fluorescence-based identification of tumor tissue for accurate resection of diseased tissue.
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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 500 MG
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BI-3231 is a chemical probe that functions as a potent and selective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It exhibits IC50 values of 1 nM for human HSD17B13 and 13 nM for mouse HSD17B13. This compound holds potential for research into nonalcoholic steatohepatitis (NASH) and various other liver diseases. The BI-3231 probe was developed by Boehringer Ingelheim and is available for free through their open innovation portal, opnMe.com, alongside its negative control.
- Potent and selective HSD17B13 inhibitor.
- IC50 values: 1 nM (hHSD17B13) and 13 nM (mHSD17B13).
- Potential for research in nonalcoholic steatohepatitis (NASH) and liver diseases.
- High metabolic stability in liver microsomes.
- Moderate metabolic stability in hepatocytes.
- Rapidly cleared from plasma, with considerable hepatic exposure maintained over 48 hours in vivo.
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eMolecules 111298-88-5 | [5-[tert-butyl(dimethyl)silyl]oxypentyl]magnesium bromide, 0.50 M in THF | Synthonix305.614 | C11H25BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)OCCCCC[Mg+] | 100ml | 844919954
[5-[tert-butyl(dimethyl)silyl]oxypentyl]magnesium bromide, 0.50 M in THF | Synthonix | 111298-88-5305.614 | C11H25BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)OCCCCC[Mg+] | 100ml | 844919954
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Medchemexpress LLC BI-4464 2 | 1227948-02-8 | 98.6% | 555.55 Da | C28H28F3N5O4 | 25MG
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BI-4464 is a selective ATP-competitive inhibitor of PTK2/FAK used as a research reagent for biochemical and cellular studies. It is provided with a reported purity of 98.64%, molecular formula C28H28F3N5O4, and a molecular weight of 555.55 Da. Intended for assay development, kinase profiling, and use as a ligand in targeted degradation studies; not for human or clinical use.
- High reported purity suitable for research applications.
- Selective ATP-competitive PTK2/FAK inhibition profile.
- Applicable to assay development and kinase profiling.
- Useful as a ligand in PROTAC and targeted degradation research.
- Available in multiple mg-scale quantities for laboratory use.
- Research use only; not intended for human or clinical use.
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eMolecules 90224-21-8 | 2-Ethylhexylmagnesium bromide, 0.25 M in THF | Synthonix - Stock | MFCD02260220 | 217.433 | C8H17BrMg | 0.000 | [Br-].CCCCC(CC)C[Mg+] | 500ml | 437237181
2-Ethylhexylmagnesium bromide, 0.25 M in THF | Synthonix - Stock | 90224-21-8 | MFCD02260220 | 217.433 | C8H17BrMg | 0.000 | [Br-].CCCCC(CC)C[Mg+] | 500ml | 437237181
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AdipoGen Naphthol AS-MX phosphate 2Na
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Chemical. CAS 96189-12-7. Formula C19H16NO5PNa2. MW BD9837. Naphthol AS-MX Phosphate is a fluorogenic substrate for alkaline phosphatases. Naphthol AS-MX Phosphate is converted to naphthol AS-MX displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications.
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