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Filtered Search Results
Medchemexpress LLC 2-amino-3-(2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-yl)propanoic acid | 174575-17-8 | 98.8% | C16H17ClNO5P | 10MG
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SDZ 220-581 is a potent, orally active, competitive NMDA receptor antagonist (reported pKi 7.7) provided for research use in neuroscience and pharmacology studies. The compound is supplied with analytical documentation and formulation options to support in vitro and in vivo experiments.
- Potent NMDA receptor antagonist (pKi 7.7).
- Orally active pharmacological profile suitable for in vivo studies.
- Competitive mode of action at NMDA receptors.
- Available as a solid and as a 10 mM solution in DMSO.
- High reported purity (≈98.8%).
- Provided with datasheet, COA, and SDS for quality assurance.
- Multiple package sizes to accommodate small-scale experiments.
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Medchemexpress LLC Revaprazan (hydrochloride) | 178307-42-1 | 25 MG
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Revaprazan hydrochloride is a reversible proton pump inhibitor that can inhibit gastric acid secretion and protect gastric mucosa. It can also inhibit IkappaB-alpha degradation and Akt inactivation, which attenuates H. pylori-induced COX-2 expression. This product can be used for research in infection and inflammation, including H. pylori-infected gastric inflammation and gastric ulcer.
- Reduces H. pylori-stimulated COX-2 expression and activity in AGS cells (5-20 μM, 24 h).
- Inhibits transcription activity of NF-κB in H. pylori-stimulated AGS cells (5-20 μM, 24 h).
- Improves the retarded cell growth in H. pylori-stimulated AGS cells (5-20 μM, 24 h).
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eMolecules 473694-19-8 | 4-Chloro-3-fluorophenylzinc bromide, 0.50 M in THF | Synthonix274.820 | C6H3BrClFZn | 0.000 | [Br-].Fc1cc([Zn+])ccc1Cl | 100ml | 703157769
4-Chloro-3-fluorophenylzinc bromide, 0.50 M in THF | Synthonix | 473694-19-8274.820 | C6H3BrClFZn | 0.000 | [Br-].Fc1cc([Zn+])ccc1Cl | 100ml | 703157769
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eMolecules 160727-03-7 | 2,4,5-Trimethylphenylmagnesium bromide, 0.5M in THF | Synthonix - Stock | MFCD02260239 | 223.396 | C9H11BrMg | 0.000 | [Br-].Cc1cc(C)c([Mg+])cc1C | 500ml | 437237438
2,4,5-Trimethylphenylmagnesium bromide, 0.5M in THF | Synthonix - Stock | 160727-03-7 | MFCD02260239 | 223.396 | C9H11BrMg | 0.000 | [Br-].Cc1cc(C)c([Mg+])cc1C | 500ml | 437237438
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eMolecules 301300-51-6 | (2-(trifluoromethyl)phenyl)zinc bromide, 0.50 M in THF | Synthonix | MFCD22685080 | 290.390 | C7H4BrF3Zn | 0.000 | [Br-].FC(F)(F)c1ccccc1[Zn+] | 25ml | 627353745
(2-(trifluoromethyl)phenyl)zinc bromide, 0.50 M in THF | Synthonix | 301300-51-6 | MFCD22685080 | 290.390 | C7H4BrF3Zn | 0.000 | [Br-].FC(F)(F)c1ccccc1[Zn+] | 25ml | 627353745
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eMolecules 352530-37-1 | 5-Ethoxycarbonyl-2-thienylzinc bromide, 0.50 M in THF | Synthonix | MFCD02260182 | 300.480 | C7H7BrO2SZn | 0.000 | [Br-].CCOC(=O)c1ccc([Zn+])s1 | 100ml | 532652828
5-Ethoxycarbonyl-2-thienylzinc bromide, 0.50 M in THF | Synthonix | 352530-37-1 | MFCD02260182 | 300.480 | C7H7BrO2SZn | 0.000 | [Br-].CCOC(=O)c1ccc([Zn+])s1 | 100ml | 532652828
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Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 50mg, CAS: 755038-02-9.
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BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
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eMolecules 10043-35-3 | Boric acid Electrophoresis grade | Oakwood Chemicals | MFCD00011337 | 61.830 | BH3O3 | 0.000 | OB(O)O | 25g | 480154983
Boric acid Electrophoresis grade | Oakwood Chemicals | 10043-35-3 | MFCD00011337 | 61.830 | BH3O3 | 0.000 | OB(O)O | 25g | 480154983
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eMolecules 91345-58-3 | 2,3,4,5,6-Pentamethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311489 | 251.450 | C11H15BrMg | 0.000 | [Br-].Cc1c(C)c(C)c([Mg+])c(C)c1C | 50ml | 437237417
2,3,4,5,6-Pentamethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 91345-58-3 | MFCD01311489 | 251.450 | C11H15BrMg | 0.000 | [Br-].Cc1c(C)c(C)c([Mg+])c(C)c1C | 50ml | 437237417
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eMolecules 2135683-40-6 | [(3R)-1-tert-butoxycarbonylpyrrolidin-3-yl]methylzinc iodide, 0.5M in THF | Synthonix | MFCD31536791 | 376.540 | C10H18INO2Zn | 0.000 | [I-].CC(C)(C)OC(=O)N1CC[C@@H](C[Zn+])C1 | 100ml | 801135327
[(3R)-1-tert-butoxycarbonylpyrrolidin-3-yl]methylzinc iodide, 0.5M in THF | Synthonix | 2135683-40-6 | MFCD31536791 | 376.540 | C10H18INO2Zn | 0.000 | [I-].CC(C)(C)OC(=O)N1CC[C@@H](C[Zn+])C1 | 100ml | 801135327
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eMolecules 288309-53-5 | 3-Cyanophenylzinc iodide, 0.50 M in THF | Synthonix294.400 | C7H4INZn | 0.000 | [I-].[Zn+]c1cccc(c1)C#N | 25ml | 627353559
3-Cyanophenylzinc iodide, 0.50 M in THF | Synthonix | 288309-53-5294.400 | C7H4INZn | 0.000 | [I-].[Zn+]c1cccc(c1)C#N | 25ml | 627353559
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eMolecules 312693-44-0 | 4-Biphenylzinc bromide, 0.50 M in THF | Synthonix | MFCD02093780 | 298.490 | C12H9BrZn | 0.000 | [Br-].[Zn+]c1ccc(cc1)-c1ccccc1 | 100ml | 532652623
4-Biphenylzinc bromide, 0.50 M in THF | Synthonix | 312693-44-0 | MFCD02093780 | 298.490 | C12H9BrZn | 0.000 | [Br-].[Zn+]c1ccc(cc1)-c1ccccc1 | 100ml | 532652623
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eMolecules 1416437-24-5 | 3-(Tributylstannyl)-2-pyridinecarbonitrile | Synthonix - Stock | MFCD22421757 | 393.162 | C18H30N2Sn | 98.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1C#N | 1g | 525924593
3-(Tributylstannyl)-2-pyridinecarbonitrile | Synthonix - Stock | 1416437-24-5 | MFCD22421757 | 393.162 | C18H30N2Sn | 98.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1C#N | 1g | 525924593
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eMolecules 1839-92-5 | 5-Chloro-2-methylbenzotrifluoride | Oakwood Chemical | MFCD09037961 | 194.580 | C8H6ClF3 | 99.000 | Cc1ccc(Cl)cc1C(F)(F)F | 1g | 537684406
5-Chloro-2-methylbenzotrifluoride | Oakwood Chemical | 1839-92-5 | MFCD09037961 | 194.580 | C8H6ClF3 | 99.000 | Cc1ccc(Cl)cc1C(F)(F)F | 1g | 537684406
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Medchemexpress LLC Anagrelide hydrochloride | 58579-51-4 | MFCD01720337 | 99.4% | 1 ML
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Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) that inhibits platelet aggregation and bone marrow megakaryocytopoiesis. It has been shown to decrease gastrointestinal stromal tumor (GIST) cell proliferation and promote apoptosis in vitro. This imidazoquinazoline derivative acts as a platelet-lowering agent and exhibits antithrombopoietic action.
- Potent inhibitor of phosphodiesterase type III (PDE3) with an IC50 of 36 nM.
- Inhibits platelet aggregation.
- Inhibits bone marrow megakaryocytopoiesis.
- Decreases gastrointestinal stromal tumor (GIST) cell proliferation.
- Promotes apoptosis in vitro.
- Potently inhibits the development of marrow megakaryocytes (IC50=26 nM).
- Induces a cytotoxic effect in the GIST882 cell line (IC50=16 nM).
- Inhibits or reduces tumor growth in GIST2B, GIST9, and GIST882 models in vivo.
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