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Filtered Search Results
Medchemexpress LLC BI-4020 | 2664214-60-0 | 99.3% | 1 ML
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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It shows activity against various EGFR variants, including the triple mutant EGFR del19 T790M C797S, the double mutant EGFR del19 T790M, and primary mutant EGFR del19. It also exhibits activity against EGFR wt.
- Inhibits EGFR del19 T790M C797S variant with an IC50 of 0.2 nM
- Inhibits EGFR del19 T790M and EGFR del19 with an IC50 of 1 nM
- Exhibits high kinome selectivity
- Possesses good DMPK properties
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Ambeed AMBEED
5000884151 2-NAPHTHALEN-2-YLACETIC 100G
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Cambridge Isotope Laboratories 1 2 3 4-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
1 2 3 4-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
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Aobchem 4-Bromo-2-(hydroxymethyl)thiophene | ≥95% | CAS 79757-77-0 | C5H5BrOS | 25g
4-Bromo-2-(hydroxymethyl)thiophene | ≥95% | CAS 79757-77-0 | C5H5BrOS | 25g
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Apexbio Technology LLC BI 6015 93987-29-2 10mg
BI 6015 is a small-molecule antagonist targeting hepatocyte nuclear factor 4 alpha (HNF4 ) a nuclear receptor implicated in transcriptional regulation within liver intestinal and pancreatic -cells It is designed to inhibit HNF4 -mediated transcriptional activation thereby modulating gene expression related to glucose and lipid metabolism BI 6015 exerts its biological activity primarily through direct antagonism of HNF4 leading to reduced transcriptional activation and lowering endogenous HNF4 protein levels In cell-based studies BI 6015 demonstrates inhibition of insulin promoter activity and suppression of endogenous insulin expression in T6PNE cells as well as decreased HNF4 protein in MIN6 and HepG2 cells Based on these pharmacological properties BI 6015 holds research potential in the study of diabetes and hepatic metabolic regulation
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Ambeed AMBEED
5000884030 135-BENZENETRICARBALDEHY 5G
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Ambeed AMBEED
5000882902 NAPHTHOL GREEN B 100G
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Aobchem 1-Naphthoic acid | ≥95% | CAS 86-55-5 | C11H8O2 | 100g
1-Naphthoic acid | ≥95% | CAS 86-55-5 | C11H8O2 | 100g
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Aobchem 5 6 7 8-Tetrahydro-1-naphthol | ≥95% | CAS 529-35-1 | C10H12O | 10g
5 6 7 8-Tetrahydro-1-naphthol | ≥95% | CAS 529-35-1 | C10H12O | 10g
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Medchemexpress LLC [1,1'-Biphenyl]-3-propanoic acid, a-amino-2'-chloro-5-(phosphonomethyl)-, (aS)- | 174575-17-8 | 98.8% | 1 ML
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SDZ 220-581 is an orally active, potent, and competitive NMDA receptor antagonist with a pKi value of 7.7. In vivo studies have demonstrated that it dose-dependently protects against maximal electroshock seizures (MES), exhibiting a rapid onset and long duration of action.
- Orally active NMDA receptor antagonist
- Potent and competitive action
- pKi value of 7.7
- Protects against maximal electroshock seizures
- Rapid onset and long duration of action
- For research use only
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Medchemexpress LLC Ald-Ph-PEG6-acid | 2055013-55-1 | 95.3% | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Ald-Ph-PEG6-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound is a colorless to light yellow viscous liquid.
- Molecular weight is 485.52
- Chemical formula is C23H35NO10
- It appears as a viscous liquid
- Its color ranges from colorless to light yellow
- Purity is 95.3%
- Storage in pure form: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
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Aobchem 2-Chloro-6-methoxynaphthalene | ≥97% | CAS 67886-68-4 | C11H9ClO | 1g
2-Chloro-6-methoxynaphthalene | ≥97% | CAS 67886-68-4 | C11H9ClO | 1g
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Selleck Chemical LLC 1-Hydroxy-2-naphthoic acid
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms
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Apexbio Technology LLC BI-D1870 501437-28-1 50mg
BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research
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Apexbio Technology LLC MK-571 115104-28-4 5mg
MK-571 (CAS 115104-28-4) also known as L-660711 is a selective antagonist of the leukotriene D4 (LTD4) receptor a G protein-coupled receptor activated by cysteinyl leukotrienes involved in inflammatory responses MK-571 demonstrates high affinity for the LTD4 receptor with reported Ki values of 0 22 nM in guinea pig lung and 2 1 nM in human lung membranes It effectively antagonizes LTD4- and LTE4-induced contractions in guinea pig and human airway tissues as indicated by pA2 values ranging from 8 5 to 10 5 In vivo MK-571 reduces airway hyperresponsiveness and leukocyte infiltration in animal models of pulmonary inflammation Additionally MK-571 acts as a specific inhibitor of multidrug resistance protein 1 (MRP1) supporting its use in studies of leukotriene signaling and drug transport mechanisms
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