Naphthalenes

Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 677.18 | 100 MG

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Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor with antitumor activity, used to treat colon and rectal cancer. It is for research use only and has been shown to inhibit the growth of various cancer cell lines, such as LoVo and HT-29.

• Inhibits topoisomerase I
• Demonstrates antitumor activity
• Suppresses proliferation of human umbilical vein endothelial cells
• Available for research use only

Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 677.18 | 1 ML

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Irinotecan hydrochloride, also known as (+)-Irinotecan hydrochloride or CPT-11 hydrochloride, is a topoisomerase I inhibitor primarily used in the treatment of colon and rectal cancer. This product is intended for research use only.

• Acts as an inhibitor of topoisomerase I, an enzyme crucial for DNA replication, transcription, and repair.
• Effectively inhibits the growth of various cancer cell lines.
• Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
• Significantly inhibits tumor growth in animal models.
• Involved in numerous clinical trials for a wide range of cancers.

eMolecules​ Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 25ml 437236954 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 25ml 437236954 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

eMolecules​ Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 50ml 437236955 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 50ml 437236955 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

eMolecules​ Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 100ml 437236956 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

Synthonix - Stock 3-tert-Butylphenylmagnesium bromide 0.5 M in THF 100ml 437236956 B31782 63488-09-5 MFCD11113494 237.423 C10H13BrMg

eMolecules​ Combi-Blocks 2-(Trimethylsilyl)ethyl 3-nitro-1h-124-triazole-1-carboxylate 5g 495746769 QH-3487 98.000 1001067-09-9 MFCD11042686 258.309 C8H14N4O4Si

Combi-Blocks 2-(Trimethylsilyl)ethyl 3-nitro-1h-124-triazole-1-carboxylate 5g 495746769 QH-3487 98.000 1001067-09-9 MFCD11042686 258.309 C8H14N4O4Si

Medchemexpress LLC 2-(2-chlorophenyl)-2-(5,7-dichloro-3-(hydroxymethyl)-4,6-dimethyl-1H-indol-2-yl)-N-((4-methylphenyl)su | 2244452-09-1 | 99.6% | 499.36 g/mol | C21H20Cl2N2O6S | 1MG

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BI-4924 is a potent, selective small-molecule inhibitor of phosphoglycerate dehydrogenase (PHGDH) used in biochemical and cellular research to probe serine biosynthesis and PHGDH-dependent metabolism. The compound is a hydroxymethylene-bearing carboxylic acid derivative (CAS 2244452-09-1) with characterized physicochemical and solubility properties.

• Potent PHGDH inhibition: IC50 = 3 nM.
• Disrupts serine biosynthesis in cells (IC50 ≈ 2.2 μM at 72 h).
• Chemical formula C21H20Cl2N2O6S; molecular weight 499.36 g/mol.
• High purity: 99.6% (reported by supplier).
• Form: powder; suitable for DMSO stock solutions.
• Solubility in vitro: DMSO 125 mg/mL (≈250 mM; ultrasonic recommended).
• In vivo formulations documented for multiple vehicles at ≥2.08 mg/mL.