Phenanthrenes and derivatives
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
TARGETMOL CHEMICALS INC MALONIC ACID 500MG
Also available in 25 mg 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency which is an inborn error of metabolism. purity: 98%
Medchemexpress LLC Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Medchemexpress LLC Amorolfine hydrochloride | 78613-38-4 | 99.6% | 200 MG
Amorolfine hydrochloride (Standard) is an analytical standard and a potent anti-fungal agent that inhibits ergosterol biosynthesis. It is intended for research and analytical applications, with potential for the research of Neoscytalidium dimidiatum onychomycosis.
- Inhibits ergosterol biosynthesis
- Possesses fungistatic and fungicidal activity
- Effective against dermatophyte fungi, filamentous fungi, pathogenic yeasts, dimorphic fungi, and dematiaceous fungi
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 200 MG
Nilotinib hydrochloride dihydrate is the dihydrate salt of nilotinib, a second-generation Bcr-Abl tyrosine kinase inhibitor used in oncology research. Supplied for research and analytical applications, it is intended for laboratory studies of chronic myelogenous leukemia mechanisms and kinase signaling. Not for human therapeutic use.
- Potent Bcr-Abl tyrosine kinase inhibitor.
- Suitable for in vitro and in vivo research models.
- High purity suitable for analytical applications (99.89%).
- Supplied as a solid with molecular weight 602.01 g/mol.
- Available in laboratory pack sizes for experimental use.
![eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475670.JPG-250.jpg)
eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Sigma Aldrich Fine Chemicals Biosciences Aristolochic acid I European Pharmacopoeia (EP) Reference Standard | 313-67-7 | MFCD00004996 |
Aristolochic acid I European Pharmacopoeia (EP) Reference Standard | Mol Wt: 341.27 | 313-67-7 | MFCD00004996 |
eMolecules Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Sigma Aldrich Fine Chemicals Biosciences Chrysene-d12 98 atom % D | 1719-03-5 | MFCD00134283 | 50MG
Chrysene-d12 98 atom % D | Purity: 99% (CP) | Mol Wt: 240.36 | 1719-03-5 | MFCD00134283 | 50MG
Medchemexpress LLC Vilazodone hydrochloride | 163521-08-2 | 100.7% | C26H28ClN5O2 | 200 MG
Vilazodone hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. This product is for research use only.
- Serotonin transporter (SER) inhibitor
- 5-HT1A receptor partial agonist
- Ships at room temperature
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture