Phenanthrenes and derivatives
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 50 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be used in research on diseases related to the central nervous system (CNS). It inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This product is for research use only and not sold to patients.
- Inhibits ABL1 (64-515) with an IC50 of 8.7 nM.
- Can be used in research on diseases related to the central nervous system (CNS).
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
- Molecular weight is 359.30.
- Appears as a solid, white to off-white in color.
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
Cayman Chemical 4-MethylpentnoIc AcId-d12 50mg
An internal standard for the quantification of 4-methylpentanoic acid by GC- or LC-MS
Medchemexpress LLC Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 100 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to ubiquitination and subsequent degradation of BCR-ABL1. It is for research use only and not sold to patients.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau for ubiquitination and degradation of BCR-ABL1.
- Exhibits cell proliferation with IC50 values of 1.11, 1.98, and 0.37 μM for BCR-ABL1 WT, T315I, and G250E cells.
- Induces the degradation of BCR-ABL1 and c-ABL1.
- Inhibits downstream signaling via the STAT5 pathway in K562 and Ba/F3 cells.
- Intended for research use only.
Medchemexpress LLC Aristolochic acid B | 475-80-9 | 311.25 | 5 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts, is mutagenic, and exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Target: DNA alkylator/crosslinker
- Research area: Cancer
- Mechanism: Forms DNA adducts and is mutagenic
- Carcinogenic risk: Exhibits greater carcinogenic risk in vivo than Aristolochic acid I
- Appearance: Solid
- Melting/freezing point: 270-272°C
TARGETMOL CHEMICALS INC Aristolochic acid B 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I. Purity 99.99%
Electron Microscopy Sciences Rosin Alcohol Working Solution 500 ML
Used in Wolbach's Giemsa Method Wolbach, Todd, and Palfrey (1922) Nuclei, collagen. References are Wolbach, S.B., Todd, J.L. and Palfrey, F.W., The Etilogy of Pathology Typhus, Harvard University Press, Cambridge, MA., p. 13 – 14,c 1922 and Luna, L.G., (ed), Manual of Histologic Staining Methods of the AFIP, 3rd Edition, McGraw-Hill, Y, p. 119, c. 1968
Medchemexpress LLC Alprenolol (hydrochloride) | 13707-88-5 | 99.8% | 285.81 | 200 MG
Alprenolol hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. It is used as an anti-hypertensive, anti-anginal, and anti-arrhythmic agent.
- Orally active non-selective β-adrenoceptor antagonist
- Antagonist of 5-HT1A and 5-HT1B receptors
- Used as an anti-hypertensive agent
- Used as an anti-anginal agent
- Used as an anti-arrhythmic agent
Selleck Chemical LLC Monoethyl malonic acid S3366-100mg
Monoethyl malonic acid (Ethyl hydrogen malonate Monoethyl malonate 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP)
TARGETMOL CHEMICALS INC MALONIC ACID 500MG
Also available in 25 mg 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency which is an inborn error of metabolism. purity: 98%
eMolecules Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
eMolecules Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4