Unsubstituted Phenols
Medchemexpress LLC 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one | 36945-98-9 | MFCD01689072 | 99.3% | 311.29 | 1 ML
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. It activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM) and is also described as a "super-cooling agent." It attenuates autoimmune neuroinflammation through modulation of the T-cell response.
- Super-agonist of the TRPM8 ion channel
- Activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM)
- "Super-cooling agent"
- Attenuates autoimmune neuroinflammation through modulation of the T-cell response
Medchemexpress LLC Phenylephrine hydrochloride | 61-76-7 | MFCD00012605 | 99.99% | 100 MG
Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87, and 4.70 for α1D, α1B, and α1A receptors, respectively. It promotes cardiac fibroblast proliferation by activating CaN and evoking NFAT3 nuclear translocation. This compound also activates p38-MAPK isoforms and SAPKs/JNKs, leading to increased heart contractility and enhanced alveolar fluid clearance. It is for research use only.
- Selective α1-adrenoceptor agonist
- Promotes cardiac fibroblast proliferation
- Activates CaN and evokes NFAT3 nuclear translocation
- Increases contractility of the heart
- Activates SAPKs/JNKs in neonatal ventricular myocytes
- Increases alveolar fluid clearance
- Accelerates absorption of pulmonary edema
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Medchemexpress LLC Luteolin 5-O-glucoside | 20344-46-1 | MFCD11656133 | ≥98.0% | 448.38 g·mol⁻¹ | C21H20O11 | 10 MG
Luteolin 5-O-glucoside is a flavonoid O-glycoside used in research to study anti-inflammatory and antioxidant mechanisms. It inhibits LPS-induced nitric oxide production and t-BHP-induced reactive oxygen species generation, and is supplied as a high-purity solid for biochemical and cell-based assays.
- Flavonoid glycoside with anti-inflammatory activity.
- Inhibits LPS-induced NO production and t-BHP-induced ROS generation.
- High purity suitable for biochemical and cell-based assays.
- Solid, light yellow to yellow appearance for easy handling.
- Packaged as a small research vial (10 mg) for screening and exploratory studies.
Enzo Life Sciences Tyrphostin 8 (10mg). CAS: 3785-90-8
The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM). Alternative name: alpha-Cyano-(4-hydroxy)cinnamonitrile. Purity: ≥98% (TLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: Ambient.
Medchemexpress LLC ML-109 | 1186649-91-1 | 99.02% | 523.58 | 100 MG
ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM. It is for research use only.
- Potent and full agonist at TSHR with an EC50 of 40 nM.
- No activity at FSHR or LHCGR.
- Surprisingly stable under neutral and basic conditions (t1/2 of ~16 h), though it degrades at low pH (t1/2 of ~3 h).
Medchemexpress LLC Isoflavone | 574-12-9 | 222.24 | 500 MG
Isoflavone is an orally available bioactive component of soy phytoestrogen with lipid-lowering and antioxidant activities. It prevents various chronic diseases by regulating fatty acid oxidation in the liver and gene expression in adipose tissue. Additionally, isoflavone is valuable in cancer and cardiovascular disease research.
- Orally available bioactive component of soy phytoestrogen
- Exhibits lipid-lowering and antioxidant activities
- Prevents chronic diseases by regulating fatty acid oxidation and gene expression
- Valuable for cancer and cardiovascular disease research
- Solid appearance
- Light brown to brown color
- Ships at room temperature in continental US