Alpha-halocarboxylic acids and derivatives
AdipoGen Rhodamine 6G bis OEAE amide
Chemical. CAS 1173097-69-2. Formula C32H40N4O4 . C4H2F6O4. MW 772.73. Synthetic. Fluorescent labelling.
AdipoGen Rhodamine 6G bis AEA amide bis
Chemical. CAS 1173097-37-4. Formula C30H37N5O2 . C4H2F6O4. MW 727.69. Synthetic. Fluorescent labelling.
Cayman Chemical GSK121 trifluoroacetate salt
The initial compound identified in a screen for PAD4 inhibitors (IC50 = 3.2 µM in functional assay) that was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199
Cayman Chemical IRL 1620 trifluoroacetate sa
A peptide ETB receptor agonist; selectively binds to ETB receptors (Ki = 16 pM) over ETA receptors (IC50 = 1.9 µM); induces contractions of isolated guinea pig trachea from 0.01-1 µM; reduces MAP in normotensive rats and SHRs and diminishes the transient depressor response in SHRs at 1 nmol/kg; reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia; improves Aβ-induced spatial memory deficits in a rat model of Alzheimer's disease
AdipoGen Saquayamycin B1
Chemical. CAS 99260-68-1. Formula C31H32O12. MW 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase NOS shown for Saquayamycin A1.
eMolecules 5437-45-6 | Benzyl 2-bromoacetate | Combi-Blocks | MFCD00000190 | 229.073 | C9H9BrO2 | 98.000 | BrCC(=O)OCc1ccccc1 | 5g | 290686646
Benzyl 2-bromoacetate | Combi-Blocks | 5437-45-6 | MFCD00000190 | 229.073 | C9H9BrO2 | 98.000 | BrCC(=O)OCc1ccccc1 | 5g | 290686646
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
eMolecules 64-69-7 | 2-iodoacetic acid | Oakwood Chemical | MFCD00002685 | 185.948 | C2H3IO2 | 0.000 | OC(=O)CI | 100g | 559840214
2-iodoacetic acid | Oakwood Chemical | 64-69-7 | MFCD00002685 | 185.948 | C2H3IO2 | 0.000 | OC(=O)CI | 100g | 559840214
Cayman Chemical Dynorphin A trifluoroacetate
A heptadecapeptide that acts as an endogenous opioid receptor agonist (Kis = 0.5-1 nM for κ, µ, and δ); has been implicated in antinociceptive functions
Cayman Chemical W140 trifluoroacetate salt
An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling
Cayman Chemical FAmidine trifluoroacetate sa
A PAD inhibitor (IC50s = 29.5 and 350 µM for PAD1 and PAD3, respectively, in vitro; irreversibly inactivates four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively)
eMolecules 1878-67-7 | 3-Bromophenylacetic acid | Apollo Scientific | MFCD00004330 | 215.046 | C8H7BrO2 | 98.000 | OC(=O)Cc1cccc(Br)c1 | 25g | 562424394
3-Bromophenylacetic acid | Apollo Scientific | 1878-67-7 | MFCD00004330 | 215.046 | C8H7BrO2 | 98.000 | OC(=O)Cc1cccc(Br)c1 | 25g | 562424394
eMolecules Ethyl 2-fluoroacetoacetate | 1522-41-4 | 5G
Matrix Scientific | Ethyl 2-fluoroacetoacetate | 5G | 1522-41-4 | MFCD06589830 | MW:144.17
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eMolecules 1878-67-7 | 3-Bromophenylacetic acid | Apollo Scientific | MFCD00004330 | 215.046 | C8H7BrO2 | 98.000 | OC(=O)Cc1cccc(Br)c1 | 100g | 562424395
3-Bromophenylacetic acid | Apollo Scientific | 1878-67-7 | MFCD00004330 | 215.046 | C8H7BrO2 | 98.000 | OC(=O)Cc1cccc(Br)c1 | 100g | 562424395