Alpha-halocarboxylic acids and derivatives
Chloroacetic Acid, Crystal, ACS, 99%, Spectrum™ Chemical
CAS: 79-11-8 Molecular Formula: C2H3ClO2 Molecular Weight (g/mol): 94.49 InChI Key: FOCAUTSVDIKZOP-UHFFFAOYSA-N IUPAC Name: 2-chloroacetic acid SMILES: OC(=O)CCl
FUJIFILM BIOSCIENCES INC Iodoacetic Acid
White to slightly yellow crystals or crystalline powder Freely soluble in water ethanol and acetone For research use only RUO
AdipoGen Bafilomycin B1
Chemical. CAS 88899-56-3. Formula C44H65NO13. MW 815.9. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic. Specific vacuolar-type H-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antitrypanosomal and antileishmanial compound. Phytotoxic. Influences the cell wall biosynthesis of Asp. niger.
AdipoGen Rhodamine 6G p-DAX amide bis
Chemical. CAS 591742-78-8. Formula C34H36N4O2 . C4H2F6O4. MW 760.72. Synthetic. Fluorescent labelling.
AdipoGen Rhodamine 6G bis AEA amide bis
Chemical. CAS 1173097-37-4. Formula C30H37N5O2 . C4H2F6O4. MW 727.69. Synthetic. Fluorescent labelling.
AdipoGen Rhodamine 6G bis OEAE amide
Chemical. CAS 1173097-69-2. Formula C32H40N4O4 . C4H2F6O4. MW 772.73. Synthetic. Fluorescent labelling.
AdipoGen Rhodamine 6G p-DAX amide bis
Chemical. CAS 591742-78-8. Formula C34H36N4O2 . C4H2F6O4. MW 760.72. Synthetic. Fluorescent labelling.
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
AdipoGen Saquayamycin B1
Chemical. CAS 99260-68-1. Formula C31H32O12. MW 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase NOS shown for Saquayamycin A1.
AdipoGen Saquayamycin B1
Chemical. CAS 99260-68-1. Formula C31H32O12. MW 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase NOS shown for Saquayamycin A1.
AdipoGen Naphthol AS-D chloroacetate
Chemical. CAS 35245-26-2. Formula C20H16ClNO3. MW BD9837. Naphthol AS-D chloroacetate NASDCA is a fluorigenic substrate for granulocyte specific esterases e.g. Proteinase 3 PR3 and Cathepsin G. It can be hydrolyzed into Naphthol AS-D by esterases to mix with diazonium salt and form insoluble red-brown precipitate in the cytoplasm that can be visualized under a microscope. This enzyme is usually considered specific for cells of granulocytic lineage. NASDCA can be used for the visualisation of cells in formalin-fixed or paraffin-embedded tissue in a substrate solution for naphthol-AS-D-chloroacetate-esterase CIAE staining. Proteinase 3 P3R is a serine protease that is found in neutrophils and a subpopulation of monocytes. It is the most specific enzyme for NASDCA hydrolysis, and it is used in a variety of diagnostic tests to detect granulocytes. Cathepsin G is another serine protease that is found in neutrophils.
AdipoGen Naphthol AS-D chloroacetate
Chemical. CAS 35245-26-2. Formula C20H16ClNO3. MW BD9837. Naphthol AS-D chloroacetate NASDCA is a fluorigenic substrate for granulocyte specific esterases e.g. Proteinase 3 PR3 and Cathepsin G. It can be hydrolyzed into Naphthol AS-D by esterases to mix with diazonium salt and form insoluble red-brown precipitate in the cytoplasm that can be visualized under a microscope. This enzyme is usually considered specific for cells of granulocytic lineage. NASDCA can be used for the visualisation of cells in formalin-fixed or paraffin-embedded tissue in a substrate solution for naphthol-AS-D-chloroacetate-esterase CIAE staining. Proteinase 3 P3R is a serine protease that is found in neutrophils and a subpopulation of monocytes. It is the most specific enzyme for NASDCA hydrolysis, and it is used in a variety of diagnostic tests to detect granulocytes. Cathepsin G is another serine protease that is found in neutrophils.
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
AdipoGen Rhodamine 6G bis OEAE amide
Chemical. CAS 1173097-69-2. Formula C32H40N4O4 . C4H2F6O4. MW 772.73. Synthetic. Fluorescent labelling.
AdipoGen Rhodamine 6G bis AEA amide bis
Chemical. CAS 1173097-37-4. Formula C30H37N5O2 . C4H2F6O4. MW 727.69. Synthetic. Fluorescent labelling.
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