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Organic compounds that consist of nitric acid with organic functional group substitutions; includes compounds that are derived from organic nitric acids.
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Nicorandil (SG-75) is a potent potassium channel activator that targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). It is a nicotinamide ester with vasodilatory and cardioprotective effects, and has potential uses for angina and ischemic heart diseases.
Potent potassium channel activator
Vasodilatory effects
Cardioprotective effects
Activates ATP-sensitive K+ channels
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Nicorandil (CAS 65141-46-0) is a small molecule that acts as a potassium channel opener and an activator of guanylate cyclase By facilitating potassium efflux nicorandil induces membrane hyperpolarization in vascular smooth muscle cells leading to vasodilation Additionally it enhances intracellular cyclic GMP (cGMP) levels through direct stimulation of guanylate cyclase subsequently activating protein kinase G (PKG) The activation of PKG results in downstream phosphorylation events that inhibit contractile processes in smooth muscle Nicorandil is widely used as a tool compound in cardiovascular research particularly in studies investigating angina vasorelaxation and cellular mechanisms of vascular tone regulation
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Isosorbide is an orally active vasodilating agent. It is researched for heart failure and angina (chest pain) and also acts as an oral hyperosmotic diuretic. It is suitable for laboratory research applications.
Acts as an orally active vasodilating agent
Can be used for the research of heart failure and angina