Organic phosphoric acids and derivatives
Medchemexpress LLC P-nitrophenyl phosphorylcholine | 21064-69-7 | MFCD00077834 | 99.6% | 304.24 g·mol⁻¹ | C11H17N2O6P | 50 MG
p-Nitrophenyl phosphorylcholine is a chromogenic substrate used to measure phospholipase C (PLC) activity. Hydrolysis by PLC releases p-nitrophenol, which can be quantified by absorbance at 405 nm under near-neutral pH. Supplied as a solid with high reported purity, it is suitable for enzymatic assays, assay development, and kinetic studies.
Apexbio Technology LLC TAK-632 1228591-30-7 10mM (in 1mL DMSO)
TAK-632 (CAS 1228591-30-7) is a selective inhibitor of RAF kinase isoforms including BRAF CRAF and the mutant BRAF-V600E exhibiting IC50 values of 8 3 nM 1 4 nM and 2 4 nM respectively By targeting the RAF family of serine/threonine kinases TAK-632 disrupts the RAS-RAF-MEK-ERK signaling pathway implicated in MAPK cascade regulation In cellular assays TAK-632 promotes BRAF-CRAF dimerization and demonstrates potent antiproliferative effects in A375 and SK-MEL-2 melanoma cell lines with GI50 values of 6 nM and 11 nM respectively In vivo oral administration in SK-MEL-2 xenograft models inhibits ERK phosphorylation and tumor growth without notable toxicity TAK-632 is suitable for investigating RAF-driven signaling and drug resistance in oncogenic pathway studies
Apexbio Technology LLC KN-92 phosphate 1135280-28-2 200mg
KN-92 phosphate is a small-molecule analog of the Ca2 /calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 It is designed as an inactive control compound to distinguish CaMKII-specific effects in experimental settings KN-92 phosphate does not inhibit CaMKII activity and thus serves as a negative control for CaMKII inhibition studies Additionally KN-92 phosphate blocks certain voltage-gated potassium (Kv) channels such as Kv1 2 and Kv1 5 reducing steady-state current amplitudes upon depolarization Based on these pharmacological properties KN-92 phosphate holds research potential in investigating mechanisms underlying CaMKII-related signaling pathways and Kv channel functions
eMolecules Ambeed / 14-Bis(2-chloroethyl)piperazine / 1g / 490540710 / A236067 / / 1009-85-4 / MFCD01703917 / 211.130 / C8H16Cl2N2
Ambeed / 14-Bis(2-chloroethyl)piperazine / 1g / 490540710 / A236067 / / 1009-85-4 / MFCD01703917 / 211.130 / C8H16Cl2N2
Medchemexpress LLC 1,3-dioleoyl-2-palmitoylglycerol | 1716-07-0 | MFCD00057803 | 100.0% | 859.39 | C55H102O6 | 10 MG
1,3-Dioleoyl-2-palmitoylglycerol is a triacylglycerol used as a lipid standard and research reagent, representative of triglycerides found in infant formula. It is supplied as a high-purity analytical standard suitable for biochemical studies and method development.
- High purity: 99.97%.
- Molecular formula C55H102O6 and molecular weight 859.39.
- Available in solid and solution formats, including 10 mg and 10 mM (1 mL in DMSO).
- Stored frozen for long-term stability; see storage guidelines for details.
- For research use only; not for human consumption.
Medchemexpress LLC 1,2-Dioleoyl-sn-glycerol | 24529-88-2 | 100.0% | C39H72O5 | 50 MG
1,2-Dioleoyl-sn-glycerol is a glycerolipid found on the plasma membrane. It comprises two fatty acid chains linked by an ester bond to a single glycerol molecule. This compound acts as an analog of diacylglycerol (DAG), a second messenger that activates protein kinase C. It has been utilized as a diacylglycerol source in the diacylglycerol O-acyltransferase 1 (DGAT1) assay and can induce acrosome reaction in human sperm.
- Glycerolipid found on the plasma membrane
- Analog of diacylglycerol (DAG)
- Activates protein kinase C
- Used as a diacylglycerol source in DGAT1 assay
- Induces acrosome reaction in human sperm
- Intended for research use only
Medchemexpress LLC Diethyl terephthalat 10g
Diethyl terephthalate (Terephthalic acid) is a monomer in the synthesis of polyethylene terephthalate (PET) material Diethyl terephthalate is usually used as a substrate for isolating PET-degrading strains[1]
Medchemexpress LLC 2,6-Piperidinedione, 3-[4-(4-methoxy-3-thienyl)-1H-1,2,3-triazol-1-yl]- | 2367619-87-0 | 99.8% | C12H12N4O3S | 25 MG
FPFT-2216 is a "molecular glue" compound that degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). It can be used for the research of cancer and inflammatory disease.
- Degrades phosphodiesterase 6D (PDE6D)
- Degrades zinc finger transcription factors Ikaros (IKZF1)
- Degrades Aiolos (IKZF3)
- Degrades casein kinase 1α (CK1α)
- Suitable for cancer research
- Suitable for inflammatory disease research
- Exhibits in vitro activity in MOLT4 cells
- Up-regulates IL-2 production in naive CD4+ T cells
- Induces significant degradation of CK-1α and IKZF1 in CRBNI391V mice
Medchemexpress LLC Dibenzyl hydrazodicarboxylate | 5394-50-3 | MFCD00022028 | 300.31 | C16H16N2O4 | 10 MG
Dibenzyl hydrazodicarboxylate is a small-molecule protein cross-linking reagent supplied for research use. It is used to cross-link proteins and other biomolecules in biochemical and structural studies.
- Protein cross-linking reagent for biochemical applications.
- CAS number 5394-50-3; molecular formula C16H16N2O4; molecular weight 300.31.
- Storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
- Purity and appearance not specified by the manufacturer.
Medchemexpress LLC Sodium phosphate dib 25g
Sodium phosphate dibasic dihydrate for molecular biology is an inorganic salt compound Sodium phosphate dibasic dihydrate for molecular biology is commonly used in molecular biology experiments and can be used as a buffer nutritional supplement and detergent
Medchemexpress LLC Trisodium phosphate (dodecahydrate) | 10101-89-0 | MFCD00149198 | 98.1% | 380.12 g/mol | Na3PO4·12H2O | 250 G
Trisodium phosphate dodecahydrate is an inorganic phosphate salt supplied as a white crystalline powder. It functions as a pH regulator, buffer component, pharmaceutical excipient, and corrosion inhibitor for iron in chloride solutions; listed CAS number is 10101-89-0 and listed purity is 98.1%.
- High purity (98.1%) suitable for laboratory use.
- Dodecahydrate form for predictable aqueous solubility and buffering.
- Solid powder form simplifies weighing and formulation.
- Useful as a pH modifier and buffer component in formulation work.
- Available in small pack sizes for bench-scale experiments.