Organic phosphoric acids and derivatives
Medchemexpress LLC 3PO | 18550-98-6 | 99.9% | 210.23 | 5 MG
3PO is an inhibitor of PFKFB3 that attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. It suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. This product is suitable for cancer research.
- Inhibits PFKFB3
- Attenuates proliferation of various cancer cell lines (IC50s of 1.4-24 μmol/L)
- Suppresses glucose uptake
- Decreases intracellular levels of Fru-2,6-BP, lactate, ATP, NAD+, and NADH
- Inhibits Jurkat cell proliferation by affecting the cell cycle
- Inhibits growth of Lewis lung carcinoma xenografts
- Inhibits tumor growth in MDA-MB231 human breast adenocarcinoma xenografts
- Inhibits tumor growth in HL-60 leukemia xenografts
TARGETMOL CHEMICALS INC E-3PO 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2 6-bisphosphatase) inhibitor. purity: 98%
Medchemexpress LLC 3PO | 18550-98-6 | 99.9% | 210.23 | 50 MG
3PO is an inhibitor of PFKFB3 that has been shown to attenuate the proliferation of several cancer cell lines with IC50s ranging from 1.4 to 24 μmol/L. It suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH. This product is intended for cancer research.
- Inhibits Jurkat cells proliferation by influencing cell cycle.
- Suppresses glycolytic flux to lactate in Jurkat cells.
- Inhibits cellular proliferation of transformed tumor cell lines.
- Suppresses the growth of Lewis lung carcinoma xenografts in C57Bl/6 mice.
- Suppresses xenograft tumorigenic growth of MDA-MB231 cells.
- Suppresses xenograft tumorigenic growth of HL-60 leukemia.
- Decreases Fru-2,6-BP and glucose uptake in C57Bl/6 mice.
Apexbio Technology LLC 3PO(Synonyms: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, 3-(3-Pyridyl)-1-(4-pyridyl)-2-propen-1-one), 50mg, CAS: 13309-08-5; 18550-98-6.
3PO (CAS 13309-08-5 18550-98-6) is a small molecule inhibitor targeting 6-phosphofructo-2-kinase (PFKFB3) a regulatory enzyme involved in cellular glucose metabolism Its mode of action involves inhibiting PFKFB3 activity leading to reduced intracellular synthesis of fructose-2 6-bisphosphate and consequently decreased glycolytic flux By perturbing glucose metabolism 3PO modulates cellular proliferation growth and survival pathways The compound is widely used in cell and animal model studies exploring tumor metabolism metabolic disorders and immunometabolism
Cambridge Isotope Laboratories Di-n-Hexyl phthalate (unlabeled) 100 ug/mL in nonane 1 2 mL
Di-n-Hexyl phthalate (unlabeled) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC Methyl trioctyl ammonium chloride | 5137-55-3 | MFCD00011862 | 98.0% | 404.16 g/mol | C25H54ClN | 100g
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant stabilizer and phase transfer catalyst in various chemical reactions especially in organic synthesis Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another making it an important ingredient in a variety of industrial processes
Cambridge Isotope Laboratories TRIBUTYL PHOSPHATE (D27, 98-99%), 1 G, 61196-26-7
TRIBUTYL PHOSPHATE (D27, 98-99%), 1 G, 61196-26-7
Medchemexpress LLC Tributyl phosphate-d27 | 61196-26-7 | MFCD01861663 | 100.0% | 293.48 g·mol⁻¹ | C12D27O4P | 25 MG
Tributyl phosphate-d27 is the deuterium-labeled analog of tributyl phosphate supplied as a high-purity isotopically labeled reagent for use as a tracer and as an internal standard in quantitative analytical methods. It is intended for laboratory research use and available in small, analytical-scale packages suitable for method development and validation.
- Deuterium-labeled internal standard for NMR, GC-MS, and LC-MS.
- High chemical purity (GC) supports accurate quantitation.
- Isotopically enriched to enable tracer and mass-shift applications.
- Small packaging options ideal for analytical method development.
- Stable under recommended storage conditions for labeled reagents.
