Vinylogous acids
Medchemexpress LLC Acetylarenobufagin | 184673-79-8 | 5 MG
Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-1) modulator, intended for research use only.
- Targets HIF-1
- Purity of 98.63%
- Molecular weight of 458.54
- Formula is C26H34O7
- Appears as a white to off-white solid
- Initial source is animals, toad
Medchemexpress LLC Polyporenic acid C | 465-18-9 | 5 MG
Polyporenic acid C is a lanostane-type triterpenoid isolated from Poria cocos. This compound induces apoptosis and exhibits anticancer activity, particularly against non-small cell lung cancer, by affecting various cellular pathways.
- Induces the cleavage of caspase-8 and caspase-3
- Causes the cleavage of PARP
- Reduces the phosphorylation level of Akt (Ser473)
- Increases the phosphorylation of PTEN and p53 (Ser15)
- Activates JNK
Medchemexpress LLC Pseudoprotodioscin | 102115-79-7 | 1031.18 | 5 MG
Pseudoprotodioscin is a furostanoside that inhibits SREBP1/2 and microRNA 33a/b levels, leading to a reduction in the gene expression responsible for the synthesis of cholesterol and triglycerides. It is intended for research use only.
- Inhibits SREBP1/2 and microRNA 33a/b levels.
- Reduces gene expression related to cholesterol and triglyceride synthesis.
- Increases ABCA1 protein and mRNA levels.
- Promotes ApoA-1-mediated cholesterol efflux.
- Reduces HMGCR, FAS, and ACC mRNA levels.
- Promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
- Purity: 99.17%.
Sigma Aldrich Fine Chemicals Biosciences 2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, >=98%, FG | 4077-47-8 | MFCD00209504 |
2,5-Dimethyl-4-methoxy-3(2H)-furanone natural, >=98%, FG | Purity: >=98% | Mol Wt: 142.15 | 4077-47-8 | MFCD00209504 |
Sigma Aldrich Fine Chemicals Biosciences 2,5-Dimethyl-4-methoxy-3(2H)-furanone >=97%, FG | 4077-47-8 | MFCD00209504 | 100G
2,5-Dimethyl-4-methoxy-3(2H)-furanone >=97%, FG | Purity: >=97% | Mol Wt: 142.15 | 4077-47-8 | MFCD00209504 | 100G
Sigma Aldrich Fine Chemicals Biosciences CP-380736 >=98% (HPLC) | 179688-29-0 | MFCD02678087 | 25MG
CP-380736 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 294.3 | 179688-29-0 | MFCD02678087 | 25MG
Sigma Aldrich Fine Chemicals Biosciences Ethyl indole-3-carboxylate European Pharmacopoeia (EP) Reference Standard | 776-41-0 | MFCD00228454 |
Ethyl indole-3-carboxylate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 189.21 | 776-41-0 | MFCD00228454 |
Sigma Aldrich Fine Chemicals Biosciences 4-Aminoantipyrine reagent grade | 83-07-8 | MFCD00003145 | 50G
4-Aminoantipyrine reagent grade | Purity: >=97% (HPLC) | Mol Wt: 203.24 | 83-07-8 | MFCD00003145 | 50G
Sigma Aldrich Fine Chemicals Biosciences Griseofulvin from Penicillium griseofulvum | 126-07-8 | MFCD00082343 | 5g
Griseofulvin from Penicillium griseofulvum | 97.0-102.0% | MW: 352.77 | 126-07-8 | MFCD00082343 | 5g
Sigma Aldrich Fine Chemicals Biosciences Hypoxanthine >=99.0% | 68-94-0 | MFCD00005725 | 5G
Hypoxanthine >=99.0% | Purity: >=99.0% | Mol Wt: 136.11 | 68-94-0 | MFCD00005725 | 5G
eMolecules Ethyl 2-amino-1-cyclopentene-1-carboxylate | 7149-18-0 | 1G | Purity: 95%
Combi-Blocks | Ethyl 2-amino-1-cyclopentene-1-carboxylate | 1G | 7149-18-0 | MFCD00216929
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Medchemexpress LLC PQ-10 | 927691-21-2 | 99.77% | 403.43 | 5 MG
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 and ED50 of 4.6 nM and 13 mg/kg, respectively. It induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia.
- Potent inhibitor of Phosphodiesterase 10A (PDE10A)
- Induces patterns of brain glucose metabolism, potentially serving as a translational biomarker
- Potential for researching psychiatric disorders like schizophrenia
- Shows region-specific increases in 2-DG uptake in the globus pallidus and the lateral habenula in mice
Medchemexpress LLC FTISADTSK acetate | 99.7% | 1029.10 | 5 MG
FTISADTSK acetate is an endogenous stable signature peptide derived from Trastuzumab. It is specifically monitored by selected reaction monitoring (SRM) and is intended solely for research applications.
- Endogenous stable signature peptide
- Monitored by selected reaction monitoring (SRM)
- Suitable for research use only
- Solid appearance, ranging from white to light brown
- Molecular weight: 1029.10
- Chemical formula: C44H72N10O18
- Soluble in water at 50 mg/mL (48.59 mM), may require sonication
- Powder storage: -80°C for 2 years or -20°C for 1 year
- Solution storage: -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
- Ships at room temperature within the continental US
Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 50 MG
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
- Potent and specific Menin-MLL inhibitor
- Applicable for research into MLL-rearranged acute leukemias (ALL and AML)
- Shows in vivo plasma IC50 of 53 nM
- Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo
Medchemexpress LLC 4-chloro-1-piperidin-4-yl-N-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyrazole-3-carboxamide | 1817698-21-7 | MFCD28386213 | >98.0% | 371.8 g/mol | C17H18ClN7O | 50MG
BDP5290 is a small-molecule kinase inhibitor selective for Rho-associated kinases (ROCK) and myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK). It is used as a research reagent in biochemical and cell-based assays to probe pathways controlling myosin light chain phosphorylation, cell motility, and tumor cell invasion.
- Potent inhibition of ROCK1 (IC50 5 nM), ROCK2 (IC50 50 nM), MRCKα (IC50 10 nM), and MRCKβ (IC50 100 nM).
- High reported purity: >98.0%.
- Molecular formula C17H18ClN7O and molecular weight 371.8 g/mol.
- Suitable for in vitro and cell-based research applications investigating cytoskeletal regulation.