Azolines
Medchemexpress LLC Irbesartan | 138402-11-6 | MFCD00864464 | 99.95% | 50 MG
Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). It works by relaxing blood vessels, which helps to lower blood pressure and increase the supply of blood and oxygen to the heart. This compound is used in research for conditions such as high blood pressure, heart failure, and diabetic kidney disease.
- Orally active Ang II type 1 (AT1) receptor blocker (ARB)
- Relaxes blood vessels
- Lowers blood pressure
- Increases blood and oxygen supply to the heart
- Used for research in high blood pressure, heart failure, and diabetic kidney disease
Medchemexpress LLC Serotonin hydrochloride | 153-98-0 | 99.97% | 250 MG
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter found in the central nervous system (CNS). It acts as an endogenous 5-HT receptor agonist and can cross the blood-brain barrier. Additionally, it functions as a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM, decreasing COMT reaction velocity and inducing robust hypersensitivity.
- Monoamine neurotransmitter in the CNS.
- Endogenous 5-HT receptor agonist.
- Capable of crossing the blood-brain barrier.
- Functions as a catechol O-methyltransferase (COMT) inhibitor.
- Decreases COMT reaction velocity.
- Induces robust hypersensitivity.
Medchemexpress LLC Thiol-PEG-CH2COOH (MW 5000) | 95.0% | SMILES: SCCOCC(O)=O.[MW 5000].[n] | 50 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are composed of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein intended for degradation, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
![Medchemexpress LLC Benzo[k]fluoranthene | 207-08-9 | 252.31 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000400457-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzo[k]fluoranthene | 207-08-9 | 252.31 | 1 MG
Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that possesses carcinogenic and genotoxic properties.
- Product type: Polycyclic aromatic hydrocarbon (PAH).
- Biological activity: Carcinogenic and genotoxic.
- Usage: For research use only; not sold to patients.
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: Solution, -20°C, protected from light, with a shelf life of 2 years.
Medchemexpress LLC Thiol-PEG5-thiol | 89141-22-0 | 250 MG
Thiol-PEG5-thiol (Bis-PEG5-thiol) is a bifunctional thiol cross-linker agent.
Medchemexpress LLC Propanoic acid, 3-(2-mercaptoethoxy)- | 1260092-48-5 | 95.0% | 150.20 | C5H10O3S | 10 MG
Thiol-PEG1-acid is a short polyethylene glycol (PEG) linker bearing a thiol (-SH) and a terminal carboxyl (-COOH). It is used as a bifunctional coupling reagent in bioconjugation and small-scale synthesis where selective thiol reactivity and carboxyl-mediated coupling are required.
- Short PEG linker with terminal thiol and carboxyl functional groups.
- Enables selective coupling via thiol chemistry, such as maleimide conjugation.
- Carboxyl group suitable for amide or ester bond formation with amines or alcohols.
- Low molecular weight (approx. 150.2 g/mol) for minimal steric hindrance.
- Typically supplied at 95.0% purity for research applications.
- Useful for bioconjugation, linker construction, and small-molecule linker design.
Medchemexpress LLC Irbesartan | 138402-11-6 | MFCD00864464 | 99.95% | 100 MG
Irbesartan is an orally active angiotensin II type 1 (AT1) receptor blocker. It relaxes blood vessels, lowers blood pressure, and increases the supply of blood and oxygen to the heart. This highly potent and specific AT1 receptor antagonist is used for the research of high blood pressure, heart failure, and diabetic kidney disease.
- Relaxes blood vessels and lowers blood pressure.
- Used for research of high blood pressure, heart failure, and diabetic kidney disease.
- Potent and specific AT1 receptor antagonist with an IC50 of 1.3 nM.
- Inhibits Ang II-induced proliferation of human aortic smooth muscle cells.
- Reduces Th22 cells chemotaxis and suppresses their differentiation.
- Exerts renoprotective effects and relieves systemic inflammation in vivo.
Apexbio Technology LLC Serotonin HCl(Synonyms: Serotonin hydrochloride, 5-Hydroxytryptamine hydrochloride, 5-HT hydrochloride), 50mg, CAS: 153-98-0.
Serotonin hydrochloride (CAS 153-98-0) is a monoamine neurotransmitter naturally derived from tryptophan that functions as an endogenous agonist of serotonin (5-HT) receptors Additionally serotonin hydrochloride acts as a non-competitive inhibitor of the enzyme catechol O-methyltransferase (COMT) exhibiting a binding affinity (Ki) of approximately 44 M Serotonin modulates diverse physiological processes including mood regulation sleep appetite sexual function and gastrointestinal activity Due to its role in mediating neurological and inflammatory pathways serotonin hydrochloride is widely utilized in research studies investigating depression anxiety disorders migraine pathophysiology and inflammation-associated hypersensitivity