Azolines
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF568 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Red fluorescent CF568 has Ex/Em at 562/583 nm One labeling of 20-50 ug Nanobody Thiol per kit
Medchemexpress LLC Thiol-PEG-CH2COOH (MW 2000) | 95.0% | 25 MG
Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thiol-PEG-CH2COOH | 95.0% | HS-(CH2-CH2-O)n-CH2COOH | 25 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. PROTACs utilize two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Target proteins selectively degraded
- Average molecular weight of 5000
- Purity of 95.0% by NMR
- Appearance is white to off-white solid
Medchemexpress LLC 3-Mercapto-1,2,4-triazole | 3179-31-5 | 98.0% | 101.13 | 250 G
1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent suitable for life science related research. It serves as a biological material or organic compound, intended for research use only and not for patient applications.
- Utilized in a study to design a surface enhanced Raman scattering based probe for fast and accurate detection of DNA markers.
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]- | 1347750-82-6 | ≥95.0% | 238.30 | 1 G
Thiol-PEG3-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands joined by a linker; one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Appearance: Liquid
- Color: Colorless to light yellow
- Formula: C9H18O5S
- Purity: ≥95.0%
- Molecular weight: 238.30
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC 1H-Benzimidazole, 2-(2-pyridinyl)- | 1137-68-4 | 99.9% | 195.22 | 10 G
2-(2′-Pyridyl)benzimidazole is a potentially tridentate ligand capable of forming stable complexes with various transition metal ions. It functions as an anti-inflammatory agent and effectively inhibits Escherichia coli methionine aminopeptidase, making it suitable for biochemical research. This compound appears as a solid, ranging from pale purple to purple or colorless to light pink and is intended for research use only.
- Functions as an anti-inflammatory agent
- Inhibits Escherichia coli methionine aminopeptidase
- IC50 of 13.3 μM in inhibiting human MetAP2 expressed in Sf9 cells
- Molecular formula: C12H9N3
- Molecular weight: 195.22
- Purity: 99.88%
- Ships at room temperature
- Stable for up to 3 years at room temperature
- Consistent with 1H NMR spectrum and LCMS
Medchemexpress LLC Thiol-PEG2-acid | 1379649-73-6 | 96.0% | 194.25 | 50 MG
Thiol-PEG2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These innovative molecules exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins. Comprising two distinct ligands connected by a linker, PROTACs offer a promising approach for targeted therapeutic development by actively removing disease-causing proteins. Thiol-PEG2-acid serves as a crucial linker component in assembling these complex PROTAC structures.
- Peg-based protac linker
- Used in the synthesis of protacs
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
Medchemexpress LLC VH032 thiol | 2098836-54-3 | 95.9% | 490.64 | 1 ML
VH032 thiol (VHL ligand 6) is a VHL ligand. It binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. VHL is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. It is also one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
- Binds to JQ1 to form PROTACs.
- Recruits VHL E3 ligase for protein degradation.
- Useful in the study of Proteolysis-targeting chimeras.
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF680 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red/near-IR CF680 dye has Ex/Em at 681/698 nm One labeling of 5-20 ug Nanobody Thiol per kit
Sigma Aldrich Fine Chemicals Biosciences Methimazole United States Pharmacopeia (USP) Reference Standard | 60-56-0 | MFCD00179321 | 200MG
Methimazole United States Pharmacopeia (USP) Reference Standard | Mol Wt: 114.17 | 60-56-0 | MFCD00179321 | 200MG
eMolecules 1415232-65-3 | 2-(6-CHLORO-1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLISOURONIUM HEXAFLUOROPHOSPHATE(V) | AstaTech | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 100g | 449750937
2-(6-CHLORO-1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLISOURONIUM HEXAFLUOROPHOSPHATE(V) | AstaTech | 1415232-65-3 | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 95.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 100g | 449750937
Cayman Chemical Methimazole, Purity: ≥98%, CAS: 60-56-0, 100 mg
An inhibitor of thyroid hormone synthesis; a substrate of thyroid peroxidase; traps oxidized iodide and prevents its use by thyroglobulin; inhibits absorption of radiolabeled iodide by the thyroid gland in rats at 0.4 mg/kg; reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat; has been used to induce hypothyroidism in mice
Apexbio Technology LLC Methimazole 60-56-0 10g
Methimazole is a small-molecule inhibitor targeting intercellular adhesion molecule-1 (ICAM-1) gene transcription It is designed to modulate ICAM-1 expression thereby regulating cell adhesion processes mediated by immunoglobulin superfamily members and integrins such as LFA-1 and Mac-1 Methimazole exerts its biological activity primarily through modulation of signal transducer and activator of transcription 1 (STAT1) In cell-based studies using thyroid cell models methimazole demonstrates inhibitory activity suppressing ICAM-1 mRNA expression induced by interferon-gamma (IFN- ) and H O Based on these pharmacological properties methimazole holds research potential in studying autoimmune thyroid conditions and as an agent to induce hypothyroidism in animal models for thyroid dysfunction research
Medchemexpress LLC DOTA-thiol | 865470-67-3 | MFCD11501203 | 98.9% | 463.55 g/mol | C18H33N5O7S | 10 MG
DOTA-Thiol is a bifunctional chelator - a macrocyclic DOTA derivative - intended for tumor pre-targeting and for conjugation to peptides and radionuclides. It contains a thiol functional group that enables site-specific attachment and is supplied at high purity for research applications.
- Bifunctional chelator with a reactive thiol group
- Enables conjugation of peptides and radionuclides
- Suitable for tumor pre-targeting and radiolabeling workflows
- High purity for research-grade use
- Available in milligram-scale pack sizes for synthesis and labeling
Medchemexpress LLC m-PEG-thiol | 134874-49-0 | MFCD21363241 | 90.0% | 750 Da (average) | (C2H4O)nC3H8OS | 500 MG
m-PEG-thiol (MW 750) is a methoxy-terminated polyethylene glycol with a terminal thiol group used for bioconjugation and surface modification. It provides a hydrophilic spacer for attaching biomolecules and for stabilizing or functionalizing metal nanoparticles via thiol-metal chemistry.
- Average molecular weight 750 Da.
- Thiol-terminated methoxy polyethylene glycol for surface attachment.
- Suitable for DNA thiolation and gold nanoparticle functionalization.
- Purity 90.0%.
- Liquid, colorless to light yellow; store cold (pure form -20°C) to preserve stability.