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Aromatic organic heterocyclic compounds that consist of benzene fused with a diazepine ring; diazepine rings are seven-membered heterocyclic compounds with two nitrogen atoms.
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FAUC 365 is a dopamine D3 receptor-selective antagonist supplied for preclinical research use. It exhibits high affinity for D3 with markedly lower affinity for D2 and D4 subtypes, and is used in studies of schizophrenia and Parkinson's disease models.
High D3 receptor selectivity (reported Ki ≈ 0.5 nM)
High purity (~98.8%)
Available in solid packs and as a solution in DMSO
Soluble in DMSO (~33.33 mg/mL); in vivo formulation guidance provided
Recommended storage for powder and solutions to preserve stability
Analytical documentation available (SDS, COA, H NMR, RP-HPLC, MS)
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Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase Renilla luciferase and substrate coelenterazine have been used as bioluminescence donors in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in the chemiluminescent detection of peroxynitrite
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Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 whose activities in turn can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However it can be used in designer receptor exclusively activated by designer drugs also known as DREADDs technology to modulate synthetic receptors in vivo [3]. purity: 99%
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