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Aromatic organic heterocyclic compounds that consist of benzene fused with a diazepine ring; diazepine rings are seven-membered heterocyclic compounds with two nitrogen atoms.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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FAUC 365 is a small-molecule dopamine D3 receptor-selective antagonist used in neuropharmacology research. It shows high affinity for the D3 receptor (Ki ≈ 0.5 nM) and is supplied as a high-purity powder for in vitro and in vivo studies.
High affinity for dopamine D3 receptor (Ki ≈ 0.5 nM).
Demonstrates selectivity over D2 and D4 receptor subtypes.
High purity suitable for research applications (purity reported ~98.75%).
Available in small pack sizes, including 10 mg.
Soluble in DMSO; in vivo formulation protocols provided.
Store powder at recommended temperatures to maintain stability.
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Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Additionally, Coelenterazine functions as a superoxide anion-sensitive chemiluminescent probe and is applicable in the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
Luminescent enzyme substrate for apoaequorin and Renilla luciferase
Bioluminescence donor in BRET for protein-protein interaction detection
Superoxide anion-sensitive chemiluminescent probe
Used in chemiluminescent detection of peroxynitrite
Applicable for measurement of free radical production
Utilized in in vitro and in vivo studies
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Coelenterazine serves as a luminescent enzyme substrate for both apoaequorin and Renilla luciferase. It has been utilized as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) for detecting protein-protein interactions. Additionally, coelenterazine is a superoxide anion-sensitive chemiluminescent probe and can be employed in the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
Luminescent enzyme substrate for apoaequorin and Renilla luciferase.
Used as a bioluminescence donor in BRET to detect protein-protein interactions.
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Clozapine (Standard) is an analytical standard intended for research and analytical applications. As an antipsychotic, it is used for the research of schizophrenia and exhibits high affinity for several neuroreceptors. Clozapine acts as a potent antagonist of dopamine D2 (Ki of 75 nM), and inhibits muscarinic M1 and serotonin 5HT2A receptors (Kis of 9.5 nM and 4 nM, respectively). It also functions as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
Potent antagonist of dopamine D2
Inhibits muscarinic M1 and serotonin 5HT2A receptors
Potent and selective agonist at the muscarinic M4 receptor
Used in schizophrenia research
Intended for research and analytical applications
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Clozapine (Standard) is an analytical reference standard of clozapine (CAS 5786-21-0) intended for laboratory use in method development, calibration, and quality control. It provides a characterized sample for assay verification and instrumental calibration in pharmaceutical and research settings.
Used as an analytical reference standard for assay calibration.
Suitable for method validation and quality control.
High purity (≥98.0%) for reliable analytical results.
Molecular weight 326.82 g/mol and formula C18H19ClN4 for identification.
Supplied as a small, accurately weighed quantity for analytical workflows.
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