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Aromatic organic heterocyclic compounds that consist of benzene fused with a diazepine ring; diazepine rings are seven-membered heterocyclic compounds with two nitrogen atoms.
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FAUC 365 is a research chemical described as a dopamine D3 receptor-selective antagonist used for in vitro pharmacology and receptor-binding studies. It is supplied in solid form and as a DMSO solution for biochemical assays.
Dopamine D3 receptor-selective antagonist.
High potency with reported Ki ≈ 0.5 nM at D3.
Purity 98.8%.
Chemical formula C23H25Cl2N3OS; molecular weight 462.44 g·mol⁻¹.
Available in small pack sizes, including 100 mg, and solution formats.
For research use only; not for human or clinical use.
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Clozapine N-oxide is a major metabolite of clozapine and a human muscarinic designer receptors (DREADDs) agonist. It activates the DREADD receptor hM3Dq and hM4Di but cannot cross the blood-brain barrier. Its parent compound, clozapine, is a potent dopamine antagonist and a potent and selective muscarinic M4 receptor agonist. For research use only.
DREADD activator
Metabolite of clozapine
Activates hM3Dq and hM4Di DREADD receptors
Cannot cross the blood-brain barrier
Solid appearance, light yellow to yellow color
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Clozapine Analogues can be used to study neurological disorders. Purity 99.6%
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Clozapine N-oxide (CNO CAS 34233-69-7) is a metabolic derivative of the atypical antipsychotic drug clozapine primarily known for its applications as a chemogenetic actuator Biologically inert in typical mammalian systems CNO selectively activates engineered muscarinic receptors such as the M3-designer receptors exclusively activated by designer drugs (DREADDs) Additionally CNO influences receptor expression levels exposure in cortical neuron cultures reduces 5-HT2 receptor density significantly Due to its specificity CNO is extensively utilized in neuroscience research to modulate neuronal activity non-invasively through chemogenetic approaches
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Clozapine (CAS 5786-21-0) is an atypical antipsychotic agent extensively studied for treating schizophrenia refractory to standard antipsychotics Clozapine exhibits high affinity binding to serotonin receptors 5-HT1c and 5-HT2 with reported pKi values of 8 07 and 7 63 respectively Additionally clozapine interacts with multiple dopamine receptor subtypes (D1-D5) displaying Ki values of 141 nM (D1) 80 nM (D2) 230 nM (D3) 89 nM (D4) and 250 nM (D5) Due to its distinctive receptor affinity profile clozapine serves as an important pharmacological tool in research on serotonin- and dopamine-mediated signaling mechanisms in psychiatric disorders
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Coelenterazine (CAS 55779-48-1) is a small molecule substrate for bioluminescent enzymes that generates a chemiluminescent signal upon oxidation by reactive oxygen species (ROS) particularly superoxide anions and peroxynitrite In rat hepatocytes it exhibits an IC50 of approximately 69 M toward superoxide anions Coelenterazine demonstrates concentration-dependent antioxidant activity enhancing cell viability and decreasing lipid peroxidation under oxidative stress induced by tert-butyl hydroperoxide It is widely applied in biomedical research including ELISA bioluminescence resonance energy transfer (BRET) high-throughput screening (HTS) and in vivo imaging studies of ROS in cancer models
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