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Organic polycyclic compounds that consist of a benzene fused with a heterocyclic pyran ring; pyran rings are six-membered non-aromatic rings with five carbon atoms, one oxygen atom, and two double bonds.
Chemical. CAS 518-75-2. Formula C13H14O5. MW 250.3. Isolated from Penicillium citrinum strain FKI-4836. Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore MPTP activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species ROS. Induces cell cycle arrest at the G0/G1 and G2/M phase.
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor which is a natural product isolated from plants in the Mundulea sericea family. purity: 98%
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Deguelin is a naturally occurring rotenoid used as a research reagent with reported activity against PI3K/Akt signaling and mitochondrial complex I. It is supplied as a solid analytical standard suitable for biochemical and cell biology studies.
Naturally occurring rotenoid with bioactivity against PI3K/Akt and mitochondrial complex I.
Suitable as an analytical standard for biochemical and cell biology assays.
High purity (~98%) for research applications.
Solid powder form, convenient for small-scale experiments.
Molecular formula C23H22O6 and molecular weight 394.42 g/mol.
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A rotenoid with diverse biological activities; inhibits mitochondrial complex I activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ODC activity in MCF-7 cells (IC50s = 6.9 and 11 nM, respectively); induces apoptosis in MCF-7 and SK-BR-3 cells at 100 nM; induces mortality in adult bruchid beetles (C. maculatus) from 10-500 ppm; induces nigrostriatal dopaminergic degeneration in rats at 6 mg/kg
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Iclaprim is a diaminopyrimidine antibiotic that inhibits bacterial dihydrofolate reductase and is active against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA). Supplied as a 10 mg research reagent, it is intended for in vitro studies and preclinical research. Molecular formula C19H22N4O3; molecular weight 354.40 g·mol⁻¹.
Potent inhibitor of bacterial dihydrofolate reductase.
Active against MRSA with reported MIC90 of 0.06 μg/mL.
Provided as a small-scale research sample for in vitro assays.
Well characterized chemically with defined formula and molecular weight.
Purity commonly reported as >98% by HPLC in supplier listings.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Iclaprim is a bacterial dihydrofolate reductase inhibitor supplied as a research-grade powder for analytical and laboratory use. It demonstrates potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, with a reported MIC90 of 0.06 μg/mL. Molecular formula C19H22N4O3; molecular weight 354.40 g/mol.
Research-grade powder form for laboratory assays.
High stated purity of 98.9% for reliable analytical results.
Potent activity against Staphylococcus aureus (MRSA).
Suitable as a reference standard or tool compound in microbiology studies.
Available in 100 mg quantity for small-scale experiments.
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A rotenoid with diverse biological activities; inhibits mitochondrial complex I activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ODC activity in MCF-7 cells (IC50s = 6.9 and 11 nM, respectively); induces apoptosis in MCF-7 and SK-BR-3 cells at 100 nM; induces mortality in adult bruchid beetles (C. maculatus) from 10-500 ppm; induces nigrostriatal dopaminergic degeneration in rats at 6 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More