Benzoxadiazoles
![Medchemexpress LLC Hexanamide, N-[(1S,2R,3E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-6-[(7-nitro | 94885-03-7 | 98.0% | 737.88 g·mol⁻¹ | C36H59N5O11 | 100 UG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000285210.png-250.jpg)
Medchemexpress LLC Hexanamide, N-[(1S,2R,3E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-6-[(7-nitro | 94885-03-7 | 98.0% | 737.88 g·mol⁻¹ | C36H59N5O11 | 100 UG
C6 NBD Glucosylceramide is a fluorescently labeled glucosylceramide derivative used to investigate sphingolipid metabolism and intracellular trafficking. The NBD fluorophore on a C6 acyl chain provides fluorescence properties suitable for imaging and plate-based assays, and the material is supplied at high purity for biochemical experiments.
- Fluorescent label suitable for microscopy and plate assays.
- Excitation 466 nm and emission 535 nm for standard fluorescence setups.
- High purity suitable for biochemical and enzymatic assays (98.0%).
- Useful for studying glucosylceramide metabolism and internalization.
- Available in small-scale vials ideal for research applications (100 μg, 500 μg).
Medchemexpress LLC 4-nitro-2,1,3-benzoxadiazol-7-amine | 10199-91-4 | 96.7% | 25 MG
NBD-amine is a fluorogenic amine used as a fluorescent probe and labeling reagent. It fluoresces weakly in aqueous solution and strongly in organic solvents, lipid membranes, and other hydrophobic environments, making it suitable for sensing, labeling, and studies of membrane-associated processes.
- Fluorogenic amine that fluoresces weakly in water and strongly in hydrophobic environments.
- Useful as a fluorescent probe and labeling reagent for synthesis and detection.
- Suitable for studying membrane interactions and lipid environments.
- Provided as a solid with purity 96.7% and molecular weight 180.12 g/mol.
- Documentation available: data sheet, safety data sheet (SDS), and certificate of analysis (COA).
Medchemexpress LLC Ikky nbd inhibitory peptide tfa | 98.2% | 3807.32 | 5 MG
IKKγ NBD Inhibitory Peptide TFA is a highly specific NF-κB inhibitor. It functions by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ, thereby blocking TNF-α-induced NF-kB activation. This peptide can significantly suppress inflammation and ameliorate cerebral ischemia-induced neurological deficits.
- Prevents p65 phosphorylation in BT-474 cells.
- Slightly inhibits BT-474 cell viability while markedly enhancing Doxorubicin's effects.
- Exhibits neuroprotective effect with reduction in DNA fragmentation in a rat model.
- Reduces striatal IL-1b level and microglial OX-42 staining.
- Protects the blood-brain barrier from ischemic insult.
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | C18H16F4N4O2S | 5 MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 protein and exhibits potent antiviral activity in cell-based assays. It is provided as a high-purity research reagent available as solids and as a DMSO solution, with characterized activity in single- and multi-cycle assays.
- Binds HIV-1 gp120 to inhibit viral entry.
- Potent antiviral activity (IC50 ≈ 89 nM; EC50 <200 nM).
- Characterized in single-cycle (0.089 μM) and multi-cycle (0.18 μM) assays.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (99.84%) suitable for research use.
- Storage recommendations provided for solids and solutions.
Medchemexpress LLC NBD-557 | 333352-59-3 | 99.4% | C17H24BrN3O2 | 25 MG
NBD-557 is a small molecule organic compound identified as a potential HIV-1 inhibitor. It targets viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the CD4 receptor without affecting later stages of the HIV-1 life cycle.
- Exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Active against X4 and R5 viruses, and laboratory-adapted HIV-1 strains, including an AZT-resistant strain.
- Binds to unliganded HIV-1 gp120, but not to the cellular receptor CD4.
Medchemexpress LLC 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole | 91366-65-3 | MFCD00036687 | 98.8% | 217.18 | C6H4FN3O3S | 10 MG
4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole is a fluorescent reagent for the sensitive and specific detection of thiols. It offers low background fluorescence and a stable fluorophore, making it suitable for thiol derivatization and fluorescence-based analytical applications. The compound is typically supplied as a yellow to green solid and should be protected from light during storage.
- Provides sensitive and specific fluorescence-based thiol detection.
- Low fluorescence background for improved signal-to-noise.
- Stable fluorophore under recommended storage conditions.
- Supplied in small, lab-scale quantities for analytical use.
- Yellow to green solid, easy to handle and store.
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | C18H16F4N4O2S | 10MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 envelope protein and blocks virus entry. It shows potent activity in cell-based assays (IC50 ≈ 89 nM against HIV-1 HXB2 pseudovirus; antiviral EC50 <200 nM) and is supplied as a high-purity research compound for in vitro studies.
- Potent gp120-directed entry antagonist with IC50 ≈ 89 nM.
- Demonstrated antiviral activity in cell assays (EC50 <200 nM).
- High purity suitable for research use (≈99.8%).
- Supplied as solid and as 10 mM solution in DMSO for screening.
- Molecular formula C18H16F4N4O2S and molecular weight 428.40 g·mol⁻1.
- Recommended storage: 4°C sealed; in solvent store at -80°C for long term.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 50 MG
NBD-Pen is a fluorescent probe designed for the selective and sensitive detection of lipid radicals in biological systems. It functions by turn-on fluorescence to directly detect lipid radicals in living cells.
- First fluorescence probe for lipid radicals
- Offers high selectivity and sensitivity (λex: 470 nm, λem: 530 nm)
- Specifically detects lipid-derived radicals over other reactive species (e.g., H2O2, ClO-, O2-?, and ?OH)
- Directly detects lipid radicals in living cells through turn-on fluorescence
- Decreases inflammation, apoptosis, and oxidative stress markers
- Applicable in various disease models such as hepatic carcinoma
Medchemexpress LLC NBD-X acid | 88235-25-0 | 99.18% | 50 MG
NBD-X acid is a fluorescent probe containing a nitrobenzoxadiazole group. It can be used to study the structure and function of biomolecules.
- Fluorescent probe containing a nitrobenzoxadiazole group.
- Useful for studying the structure and function of biomolecules.
Medchemexpress LLC NBD-F (4-Fluoro-7-nitrobenzofurazan) | 29270-56-2 | 98.9% | 5 MG
NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent developed for amino acid analysis. It reacts with primary or secondary amines to create a fluorescent product, and is used for the analysis of amino acids and low molecular weight amines.
- Pro-fluorescent reagent for amino acid analysis.
- Reacts with primary or secondary amines to produce a fluorescent product.
- Used for analysis of amino acids and low molecular weight amines.
- Derivatives are highly stable.
- Derivatization procedure is simple.
Medchemexpress LLC MBD (7-(p-methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole) | 33984-50-8 | 99.6% | C14H12N4O4 | 100 MG
MBD is a fluorescent probe utilized for investigating protein and nucleoprotein conformation. It has been successfully applied to bacterial ribosomes as well as bovine trypsinogen and trypsin.
- Fluorescent probe for investigating protein and nucleoprotein conformation.
- Successfully applied to bacterial ribosomes, bovine trypsinogen, and trypsin.
- Strong fluorescence when binding to hydrophobic regions of macromolecules.
Medchemexpress LLC 4-amino-7-nitro-2,1,3-benzoxadiazole | 10199-91-4 | 96.7% | 5MG
4-amino-7-nitro-2,1,3-benzoxadiazole | 10199-91-4 | 96.7% | 5MG
Medchemexpress LLC N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-phosphatidylethanolamine, triethylammonium salt | 178119-00-1 | MFCD00467850 | 95.0% | 956.26 g/mol | C49H90N5O11P | 10 MG
NBD-PE is an NBD-labeled phosphatidylethanolamine fluorescent probe used to label membranes and monitor lipid trafficking and membrane dynamics. It exhibits environment-sensitive green fluorescence (excitation ~463 nm, emission ~526 nm) and is supplied as a solid for laboratory use. CAS 178119-00-1; molecular weight ~956.26 g/mol.
- Green fluorescent NBD label with excitation ~463 nm and emission ~526 nm.
- Integrates into lipid bilayers for membrane labeling and tracking.
- Environment-sensitive fluorescence suitable for monitoring membrane order.
- Available in small laboratory quantities for experimental use.
- Supplied as a solid with a brown to black physical appearance.
- CAS 178119-00-1; molecular weight 956.26 g/mol.
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 100 MG
NBD-14189 is a potent HIV-1 entry antagonist, binding to HIV-1 gp120 and demonstrating potent antiviral activity against the HIV-1HXB2 pseudovirus. It shows anti-HIV-1 activity in both single-cycle and multi-cycle assays.
- Potent HIV-1 entry antagonist
- Binds to HIV-1 gp120
- Exhibits potent antiviral activity (EC50 < 200 nM)
- Prevents HIV-1 mediated cell-cell fusion
- Shows weak or no inhibition of the hERG current