Benzoxadiazoles
Medchemexpress LLC Int-767 | 1000403-03-1 | 99.8% | 494.66 g/mol | C25H43NaO6S | 10MG
INT-767 is a semisynthetic dual farnesoid X receptor (FXR) and TGR5 (GPBAR1) agonist used in preclinical research to modulate bile acid signaling, liver, and metabolic pathways. The compound shows mean EC50s of 30 nM for FXR and 630 nM for TGR5, and is supplied as the sodium salt with high reported purity.
Sigma Aldrich Fine Chemicals Biosciences 7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | 84806-27-9 | MFCD02682109 | 25MG
7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | Purity: >=98% | Mol Wt: 235.19 | 84806-27-9 | MFCD02682109 | 25MG
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | C18H16F4N4O2S | 10MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 envelope protein and blocks virus entry. It shows potent activity in cell-based assays (IC50 ≈ 89 nM against HIV-1 HXB2 pseudovirus; antiviral EC50 <200 nM) and is supplied as a high-purity research compound for in vitro studies.
- Potent gp120-directed entry antagonist with IC50 ≈ 89 nM.
- Demonstrated antiviral activity in cell assays (EC50 <200 nM).
- High purity suitable for research use (≈99.8%).
- Supplied as solid and as 10 mM solution in DMSO for screening.
- Molecular formula C18H16F4N4O2S and molecular weight 428.40 g·mol⁻1.
- Recommended storage: 4°C sealed; in solvent store at -80°C for long term.
Apexbio Technology LLC NBD-Cl 10199-89-0 500mg
NBD-Cl (10199-89-0) is a fluorescent labeling reagent that covalently reacts with nucleophilic groups specifically amines and thiols It is designed to derivatize these functional groups enabling detection through the formation of highly fluorescent conjugates NBD-Cl exerts its biological utility primarily through its electrophilic reaction mechanism with free amino and thiol groups in biomolecules No specific experimental model or quantitative activity metric is provided Based on these chemical properties NBD-Cl holds research potential in the labeling and detection of amino acid residues peptides proteins and thiol-containing enzymes as well as in studies of enzyme activities and biomolecular interactions
Accela Chembio Inc 4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 50 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Functions as a CD4 mimetic
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | C18H18F3N5O2S | 5 MG
NBD-14270 is a pyridine analogue that functions as a potent HIV-1 entry antagonist by binding to the gp120 envelope protein. It exhibits sub-micromolar antiviral activity with low cytotoxicity and is provided for research applications with characterized purity, formula, and storage recommendations.
- High purity: 99.53%.
- Chemical formula: C18H18F3N5O2S; molecular weight: 425.43.
- CAS number: 2411819-82-2.
- Recommended solvent: DMSO; use ultrasonic aid for dissolution.
- Storage: solid at 4°C; in solvent store at -80°C for long-term stability.
- Typical applications: in vitro antiviral and HIV-1 entry assays.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 390.46 | C19H28N5O4 | 5 MG
NBD-Pen is a turn-on fluorescent probe for selective detection of lipid-derived radicals in biological systems. It enables live-cell imaging and biochemical studies of lipid peroxidation and oxidative stress with sensitive fluorescence readout.
- High selectivity and sensitivity for lipid radicals.
- Turn-on fluorescence enables low-background detection in cells.
- Excitation at 470 nm and emission at 530 nm for standard imaging.
- High purity (99.94%) suitable for research use.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light; follow solvent storage guidelines.
Sigma Aldrich Fine Chemicals Biosciences 7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | 84806-27-9 | MFCD02682109 | 10MG
7-Fluorobenzofurazan-4-sulfonic acid ammonium salt >=98% | Purity: >=98% | Mol Wt: 235.19 | 84806-27-9 | MFCD02682109 | 10MG
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.94% | 10 MG
NBD-Pen is the first fluorescence probe for lipid radicals, offering high selectivity and sensitivity (λex: 470 nm, λem: 530 nm). It specifically detects lipid-derived radicals over other reactive species found in biological systems, including H2O2, ClO-, O2•-, and •OH. NBD-Pen directly detects lipid radicals in living cells through turn-on fluorescence. It has been observed to decrease inflammation, apoptosis, and oxidative stress markers, and can be utilized in various disease models such as hepatic carcinoma.
- First fluorescence probe for lipid radicals.
- High selectivity and sensitivity (λex: 470 nm, λem: 530 nm).
- Specifically detects lipid-derived radicals over other reactive species (H2O2, ClO-, O2•-, and •OH).
- Directly detects lipid radicals in living cells by turn-on fluorescence.
- Decreases inflammation, apoptosis, and oxidative stress markers.
- Applicable for studying various disease models, including hepatic carcinoma.
Medchemexpress LLC NBD-F (4-fluoro-7-nitrobenzofurazan) | 29270-56-2 | MFCD00010196 | 98.0% | 183.10 | C6H2FN3O3 | 10 MG
NBD-F (4-fluoro-7-nitrobenzofurazan) is a pro-fluorescent derivatization reagent that reacts with primary and secondary amines to produce stable fluorescent adducts. It is used for amino acid analysis, HPLC fluorescence detection, and other sensitive analytical applications.
- Pro-fluorescent reagent for derivatizing primary and secondary amines.
- Excitation 445 nm, emission 515 nm for fluorescence detection.
- Molecular weight 183.10 g/mol; formula C6H2FN3O3.
- Typical purity approximately 98.0%.
- Light yellow solid; store protected from light at 4°C; freeze solutions for long-term storage.