Biotin and derivatives
Medchemexpress LLC Azido-PEG9-NHS ester | 2801772-87-0 | >98% | C25H44N4O13 | 50 MG
Azido-PEG9-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. For optimal stability, store in a tightly sealed container in a cool, well-ventilated area, away from direct sunlight and ignition sources.
- Can be used in the synthesis of PROTACs
- Features an Azide group for click chemistry applications
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
- Recommended storage at -20°C for up to 3 years in pure form
Medchemexpress LLC Biotin-PEG8-acid | 2143964-62-7 | 99.8% | C29H53N3O12S | 50 MG
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Appears as a white to off-white solid
- Molecular weight: 667.81
Medchemexpress LLC Norbornene-NHS | 1888335-48-5 | C12H13NO5 | 100 MG
Norbornene-NHS is a click chemistry reagent that functions as a dienophile. It is utilized for conjugation through copper-free Click reactions with tetrazines.
- Classified as a click chemistry reagent.
- Acts as a dienophile.
- Used for conjugation.
- Conjugation occurs via copper-free click reactions.
- Reacts with tetrazines in the conjugation process.
- For research use only and not intended for human use.
eMolecules Biotin-PEG11-Amine | 1418022-42-0 | 1G | Purity: 98%
Broadpharm | Biotin-PEG11-Amine | 1G | 1418022-42-0 | MFCD22689140 | MW:70.091
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Medchemexpress LLC Azido-PEG6-NHS ester | 2055014-64-5 | 98.0% | 476.48 g/mol | C19H32N4O10 | 50 MG
Azido-PEG6-NHS ester is a cleavable six-unit polyethylene glycol (PEG) linker containing an azide and an N-hydroxysuccinimide (NHS) ester. It is used as a click-chemistry reagent for conjugation reactions and as a linker in antibody-drug conjugate and PROTAC synthesis.
- Cleavable six-unit PEG linker for bioconjugation.
- Azide group enables CuAAC and SPAAC click reactions.
- NHS ester reacts with primary amines for efficient coupling.
- Molecular weight 476.48 g/mol, formula C19H32N4O10.
- Purity 98.0% and liquid form, colorless to light yellow.
- Store pure material at -20°C; in solvent store at -80°C or -20°C as specified.
- Available in small quantities such as 50 mg for lab-scale use.
Medchemexpress LLC Bis-PEG9-NHS ester 250mg | 1008402-79-6 | 250 MG
Bis-PEG9-NHS ester is a homobifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups, used for amine-directed bioconjugation in the synthesis of PROTACs and antibody-drug conjugates. The PEG9 spacer increases hydrophilicity to improve solubility and reduce steric hindrance during conjugation.
- Contains two NHS ester reactive groups for amine coupling.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- High purity (≥98.0%) suitable for research and conjugation chemistry.
- Molecular weight 708.71 g/mol and chemical formula C30H48N2O17.
- Viscous, colorless to light yellow appearance for easy handling.
- Applicable to protein labeling, bioconjugation, and linker synthesis.
Medchemexpress LLC Sulfo-NHS-LC-LC-biotin | 194041-66-2 | 99.3% | 669.74 g/mol | C26H40N5NaO10S2 | 10 MG
Sulfo-NHS-LC-LC-Biotin is a water-soluble, amine-reactive biotinylation reagent that contains a sulfo-NHS ester joined to biotin via a long-chain spacer arm to reduce steric hindrance and improve labeling efficiency. It reacts selectively with primary amines to form stable amide bonds and is commonly used to label proteins on intact exosomes and cell surfaces.
- Water soluble sulfo-NHS ester for aqueous labeling.
- Long-chain spacer reduces steric hindrance and improves accessibility.
- Reacts selectively with primary amines to form stable amide bonds.
- Suitable for labeling proteins on intact exosomes and crowded surfaces.
- Provided as a small-quantity powder for convenient handling in research workflows.
Medchemexpress LLC EphA2 Human Biotin 100ug
The EphA2 protein is an important member of the ephrin receptor subfamily that mediates developmental events particularly in the nervous system It has a single kinase domain and an extracellular region that binds ephrin-A ligands EphA2 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived EphA2 protein expressed by HEK293 with C-6 His C-Avi labeled tag
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | 98.6% | 354.31 g/mol | C15H18N2O8 | 1 G
Mal-PEG2-NHS ester is a non-cleavable ADC linker combining a maleimide reactive group, a two-unit polyethylene glycol spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied as a purified reagent for bioconjugation and linker chemistry applications.
- Non-cleavable maleimide-NHS bifunctional linker
- PEG2 spacer improves solubility and reduces steric hindrance
- NHS ester enables efficient coupling to primary amines
- Maleimide group enables thiol-selective conjugation
- High purity suitable for ADC synthesis and bioconjugation
Sigma Aldrich Fine Chemicals Biosciences Biotin, 58-85-5, MFCD00005541, 1g
Empirical Formula (Hill Notation) C10H16N2O3S, ≥99% (HPLC), Molecular Weight 244.31, lyophilized powder, Synonym: D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H; Biotin may be used to elute proteins from avidin/streptavidin resins.
![Medchemexpress LLC Carbonic acid, bicyclo[2.2.1]hept-5-en-2-yl (2,5-dioxo-1-pyrrolidinyl) ester | 1888335-48-5 | 92.1% | 251.24 g/mol | C12H13NO5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286309.png-250.jpg)
Medchemexpress LLC Carbonic acid, bicyclo[2.2.1]hept-5-en-2-yl (2,5-dioxo-1-pyrrolidinyl) ester | 1888335-48-5 | 92.1% | 251.24 g/mol | C12H13NO5 | 10 MG
Norbornene-NHS is a click-chemistry reagent that functions as a norbornene-derived NHS carbonate dienophile for inverse electron-demand Diels-Alder (IEDDA) conjugation with tetrazines. It is provided for research use to enable efficient amine bioconjugation and labeling applications.
- Dienophile for inverse electron-demand Diels-Alder (IEDDA) conjugation with tetrazines.
- NHS carbonate functional group enables efficient coupling to primary amines.
- Available in small quantities suitable for labeling and bioconjugation experiments.
- Typical purity about 92.1% and molecular weight 251.24 g/mol.
- Store sealed and away from moisture; solid at -20°C; in solvent: -80°C for up to 6 months, -20°C for 1 month.
- Supplied for research use only.
Medchemexpress LLC Azido-PEG8-NHS ester | 1204834-00-3 | MFCD13184949 | 99.5% | 564.58 | C23H40N4O12 | 1 G
Azido-PEG8-NHS ester is an azide-functional polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester reactive group used for amine bioconjugation and click chemistry in ADC and PROTAC linker synthesis.
- Enables NHS-amine coupling to primary amines.
- Azide group enables copper-catalyzed and strain-promoted click chemistry.
- PEG8 spacer increases solubility and reduces steric hindrance.
- High reported purity for reliable conjugation performance.
- Available in small laboratory pack suitable for research-scale work.
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | MFCD01867746 | 98.0% | 2000 (average) | (C2H4O)nC7H9NO5 | 100 MG
m-PEG-NHS ester (MW 2000) is an NHS-activated methoxy poly(ethylene glycol) reagent for PEGylation of biomolecules. It reacts with primary amines to modify proteins, peptides, and small molecules to improve solubility, stability, and pharmacokinetics. Supplied as a white to off-white solid for research use, it is offered in multiple pack sizes and stored sealed away from moisture.
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 g/mol | C14H24N6O3S | 100 MG
Biotin-PEG1-azide is a biotin-labeled, single-unit polyethylene glycol (PEG1) azide reagent used for bioconjugation and as an ADC linker. The azide functional group enables click chemistry coupling, while the biotin tag allows affinity capture and detection.
- Biotin-labeled PEG1 azide for affinity capture
- Azide group for copper-catalyzed or strain-promoted click chemistry
- High purity suitable for bioconjugation
- Available as a 100 MG solid
- Store solid at -20 °C; in solution store at -80 °C for long-term
Chem-Impex International, Inc. Biotinyl-e-aminocaproic acid-N-hydroxysuccinimide ester | 72040-63-2 | MFCD00065502 | 1G
Biotinyl-e-aminocaproic acid-N-hydroxysuccinimide ester, 72040-63-2, MFCD00065502, 1G