Dithioles
Medchemexpress LLC Malotilate | 59937-28-9 | C12H16O4S2 | 50 MG
Malotilate is an orally active hepatotropic agent and an anti-fibrotic substance. It selectively inhibits 5-lipoxygenase (5-LOX) with an IC50 of 4.7 μM. It helps prevent the development of hepatocytic injury in alcohol-pyrazole hepatitis by reducing hepatic acetaldehyde levels and preventing the retention of transferrin in hepatocytes.
- Selectively inhibits 5-lipoxygenase (5-LOX) (IC50=4.7 μM).
- Prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels.
- Prevents the retention of transferrin in the hepatocytes.
Medchemexpress LLC Malotilate (NKK 105) | 59937-28-9 | 99.5% | C12H16O4S2 | 1 ML
Malotilate (NKK 105) is an orally active hepatotropic agent and an anti-fibrotic substance. It selectively inhibits 5-lipoxygenase (5-LOX) with an IC50 of 4.7 μM, preventing hepatocytic injury in alcohol-pyrazole hepatitis and reducing hepatic acetaldehyde levels.
- Prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis
- Decreases hepatic acetaldehyde levels
- Prevents the retention of transferrin in the hepatocytes
- Reduces collagen synthesis and cell migration activity of fibroblasts in vitro
- Demonstrated to prevent acute experimental liver injury induced by various hepatotoxic compounds
Medchemexpress LLC Malotilate | 59937-28-9 | 99.47% | C12H16O4S2 | 25 MG
Malotilate is an orally active hepatotropic and anti-fibrotic agent that selectively inhibits 5-lipoxygenase (5-LOX) with an IC50 of 4.7 μM. It prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing transferrin retention in hepatocytes.
- Selectively inhibits 5-lipoxygenase (5-LOX)
- Prevents hepatocytic injury in alcohol-pyrazole hepatitis
- Decreases hepatic acetaldehyde levels
- Prevents retention of transferrin in hepatocytes
- Reduces collagen synthesis and cell migration activity of fibroblasts in vitro
- Prevents acute experimental liver injury induced by various hepatotoxic compounds
- Normalizes reduced serum cholesterol levels in rats with carbon tetrachloride-induced liver damage
Apexbio Technology LLC Malotilate 59937-28-9 5mg
Malotilate (CAS 59937-28-9) is a diethyl ester derivative investigated for its hepatotropic properties notably its ability to enhance protein metabolism and promote hepatocyte regeneration Mechanistically Malotilate modulates vascular endothelial cell function reducing endothelial permeability induced by serum deprivation and inhibiting the invasion of tumor cells through endothelial barriers as demonstrated in rat lung endothelial cell models In vivo studies show that oral administration of Malotilate significantly suppresses pulmonary metastasis in rat models of mammary carcinoma Clinically Malotilate has been reported to accelerate the recovery of impaired protein metabolism in alcoholic liver disease suggesting its utility in hepatic disease research
Medchemexpress LLC Malotilate | 59937-28-9 | 99.5% | C12H16O4S2 | 100 MG
Malotilate is an orally active hepatotropic agent and an anti-fibrotic substance. It selectively inhibits 5-lipoxygenase (5-LOX) with an IC50 of 4.7 μM. It prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes. For research use only.
- Reduces collagen synthesis and cell migration activity of fibroblasts in vitro
- Stimulates 12- and 15-lipoxygenase pathways
- Prevents acute experimental liver injury induced by various hepatotoxic compounds
- Normalizes lowered serum cholesterol in rats with hypocholesterolemia
- Normalizes inhibition of triglyceride secretion from livers in rats with CCl4-induced liver damage